Volume 151, Issue 2, June 2016

Look Inside ToxSci

From the Editor’s Desk, Editor’s Highlights

Toxicological Sciences, Volume 151, Issue 2, June 2016, Page 205, https://doi.org/10.1093/toxsci/kfw075

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Forum: Value of GLP for Regulatory Decisions

Does GLP enhance the quality of toxicological evidence for regulatory decisions?

Christopher J. Borgert and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 206–213, https://doi.org/10.1093/toxsci/kfw056

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Urinary Markers of Drug-Induced Kidney Injury

Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury

Jonathan A. Phillips and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 214–223, https://doi.org/10.1093/toxsci/kfw038

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Screening of Compounds that Attenuate Chromosomal Damage

Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine

Shun Matsuda and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 224–235, https://doi.org/10.1093/toxsci/kfw039

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Cognitive Effects of Tobacco Smoke Components

Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone

Brandon J. Hall and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 236–244, https://doi.org/10.1093/toxsci/kfw042

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Activation of Nitric Oxide as Mechanism of Antibody-Induced Vascular Toxicity

Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys

Rama Pai and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 245–260, https://doi.org/10.1093/toxsci/kfw037

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Identification of Cholesterol Biosynthesis Inhibitors

Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis

Josi Herron and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 261–270, https://doi.org/10.1093/toxsci/kfw041

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Constitutive Androstane Receptor in Herbicide-Associated Liver Injury

Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development

Kazunori Kuwata and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 271–285, https://doi.org/10.1093/toxsci/kfw040

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Evaluation of Ortho-Phthalate Activities and Hazards in ToxCast

Using ToxCast to Explore Chemical Activities and Hazard Traits: A Case Study With Ortho-Phthalates

Nathalie Pham and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 286–301, https://doi.org/10.1093/toxsci/kfw049

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Irritation Assay for Identifying Chemicals that Induce Injection Site Reactions

In Vitro L6 Irritation Assay Predicts Clinical Injection Site Reactions for Small Molecules

Jeffrey A. Willy and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 302–311, https://doi.org/10.1093/toxsci/kfw050

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Vinyl Chlorine and Lipopolysaccharide in Liver Injury

Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice

Lisanne C. Anders and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 312–323, https://doi.org/10.1093/toxsci/kfw045

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Lead-Induced Alterations in Gut Microbiota Composition

Perinatal Lead Exposure Alters Gut Microbiota Composition and Results in Sex-specific Bodyweight Increases in Adult Mice

Jianfeng Wu and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 324–333, https://doi.org/10.1093/toxsci/kfw046

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Sulfur Dioxide and Cardiac Dysfunction

Sulfur Dioxide Contributes to the Cardiac and Mitochondrial Dysfunction in Rats

Guohua Qin and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 334–346, https://doi.org/10.1093/toxsci/kfw048

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Systematic Review of Acrolein Mode of Action from Tobacco Smoke

Proposed Mode of Action for Acrolein Respiratory Toxicity Associated with Inhaled Tobacco Smoke

R. Philip Yeager and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 347–364, https://doi.org/10.1093/toxsci/kfw051

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Extracellular Vesicles and Drug-Induced Liver Injury

Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?

Natalie S. Holman and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 365–375, https://doi.org/10.1093/toxsci/kfw047

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Role of Cancer Stem-Like Cells in Nickel-Related Malignancies

Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation

Lei Wang and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 376–387, https://doi.org/10.1093/toxsci/kfw044

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Chlorodopamine as a Novel Mediator of Dopamine Neuron Injury

Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons

Thomas M. Jeitner and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 388–402, https://doi.org/10.1093/toxsci/kfw052

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The Constitutive Androstane Receptor and Bile Acid Homeostasis

Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver

Andrew J. Lickteig and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 403–418, https://doi.org/10.1093/toxsci/kfw054

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Hydroxyacids from Diatoms Adversely Affect Sea Urchin Function

First Morphological and Molecular Evidence of the Negative Impact of Diatom-Derived Hydroxyacids on the Sea Urchin Paracentrotus lividus

Stefano Varrella and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 419–433, https://doi.org/10.1093/toxsci/kfw053

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GPCR-Estrogen Receptor Agonist Acts as Inhibitor at Nuclear Estrogen Receptor

The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures

L. Cody Smith and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 434–446, https://doi.org/10.1093/toxsci/kfw057

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Connectivity Mapping to Group Chemicals Using Mode of Action

Grouping 34 Chemicals Based on Mode of Action Using Connectivity Mapping

K. Nadira De Abrew and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 447–461, https://doi.org/10.1093/toxsci/kfw058

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Corrigendum

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe^−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes

Blaine Phillips and others

Toxicological Sciences, Volume 151, Issue 2, June 2016, Pages 462–464, https://doi.org/10.1093/toxsci/kfw062

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COVER

Cover

Toxicological Sciences, Volume 151, Issue 2, June 2016, Page i1, https://doi.org/10.1093/toxsci/kfv282

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STANDING MATERIAL

Editorial Board

Toxicological Sciences, Volume 151, Issue 2, June 2016, Page i2, https://doi.org/10.1093/toxsci/kfv283

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Subscriptions

Toxicological Sciences, Volume 151, Issue 2, June 2016, Page i3, https://doi.org/10.1093/toxsci/kfv284

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Table of Contents

Toxicological Sciences, Volume 151, Issue 2, June 2016, Page i4, https://doi.org/10.1093/toxsci/kfv285

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