Volume 150, Issue 1, March 2016

Look Inside ToxSci

From the Editor’s Desk, Editor’s Highlights

Toxicological Sciences, Volume 150, Issue 1, March 2016, Page 1, https://doi.org/10.1093/toxsci/kfw016

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Editorial

Toxicology: Cajun Style

Gary W. Miller

Toxicological Sciences, Volume 150, Issue 1, March 2016, Page 2, https://doi.org/10.1093/toxsci/kfw027

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Profiling of microRNA after Liver Injury

Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats

Rachel J. Church and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 3–14, https://doi.org/10.1093/toxsci/kfv260

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Polychlorinated Biphenyls and Manganese Toxicity

Dietary Manganese Modulates PCB126 Toxicity, Metal Status, and MnSOD in the Rat

Bingxuan Wang and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 15–26, https://doi.org/10.1093/toxsci/kfv312

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Sulfotransferases and Tolvaptan Toxicity

Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan

Jia-Long Fang and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 27–39, https://doi.org/10.1093/toxsci/kfv311

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Silica Nanoparticles and Immune Function

Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells

Luisana Di Cristo and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 40–53, https://doi.org/10.1093/toxsci/kfv258

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Aflatoxin B1 and Gut Microbiome Disruption

Aflatoxin B₁ Induced Compositional Changes in Gut Microbial Communities of Male F344 Rats

Jincheng Wang and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 54–63, https://doi.org/10.1093/toxsci/kfv259

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Identification of Transcriptional Targets Using Computational Approaches

Discovery of Transcriptional Targets Regulated by Nuclear Receptors Using a Probabilistic Graphical Model

Mikyung Lee and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 64–73, https://doi.org/10.1093/toxsci/kfv261

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Arsenic Effects on Cerebellar Astrocytes

Diphenylarsinic Acid Induced Activation of Cultured Rat Cerebellar Astrocytes: Phosphorylation of Mitogen-Activated Protein Kinases, Upregulation of Transcription Factors, and Release of Brain-Active Cytokines

Takayuki Negishi and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 74–83, https://doi.org/10.1093/toxsci/kfv310

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Glucose, microRNA and Thioredoxin Signaling

MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis

Daoyin Dong and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 84–96, https://doi.org/10.1093/toxsci/kfv313

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Phthalate and Reproductive Effects in Female Mice

Acute Exposure to Di(2-Ethylhexyl) Phthalate in Adulthood Causes Adverse Reproductive Outcomes Later in Life and Accelerates Reproductive Aging in Female Mice

Patrick R. Hannon and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 97–108, https://doi.org/10.1093/toxsci/kfv317

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Improving Toxicokinetic Assessment in Preclinical Studies

Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression

Emma C. Martin and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 109–116, https://doi.org/10.1093/toxsci/kfv316

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Methylmercury and Disrupted Calcium Signaling in Rat Brain

Multiple Sources of Ca²⁺ Contribute to Methylmercury-Induced Increased Frequency of Spontaneous Inhibitory Synaptic Responses in Cerebellar Slices of Rat

Yukun Yuan and William D. Atchison

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 117–130, https://doi.org/10.1093/toxsci/kfv314

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Toxicity of Silver Nanoparticles Versus Silver Ions

Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks

Mary D. Boudreau and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 131–160, https://doi.org/10.1093/toxsci/kfv318

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Sphingosine Kinase Phosphorylation of Fingolimod and Neural Tube Defects

Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects

Nicole M. Gardner and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 161–168, https://doi.org/10.1093/toxsci/kfv321

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DDE and Macrophage Function

Exposure to p,p′-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction

Lauren H. Mangum and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 169–177, https://doi.org/10.1093/toxsci/kfv315

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Aniline and Acetominophen (Paracetamol) in Female Reproduction

Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility

Jacob Bak Holm and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 178–189, https://doi.org/10.1093/toxsci/kfv332

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Expanded ToxTracker Assay for Genotoxicity

The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding

Giel Hendriks and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 190–203, https://doi.org/10.1093/toxsci/kfv323

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Mitochondrial Effects of Low Dose Acetominophen

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

Jiangting Hu and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 204–215, https://doi.org/10.1093/toxsci/kfv319

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Chromatin Modification and Gene Expression after Ozone Exposure

Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression

Shaun D. McCullough and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 216–224, https://doi.org/10.1093/toxsci/kfv324

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Toxicity Assessment in Cryopreserved Lung Sections

Screening for Chemical Toxicity Using Cryopreserved Precision Cut Lung Slices

Christa Y. Watson and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 225–233, https://doi.org/10.1093/toxsci/kfv320

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Acrolein as a Component of Thirdhand Smoke

Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation

Vasundhra Bahl and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 234–246, https://doi.org/10.1093/toxsci/kfv327

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Biomarkers of Skeletal Muscle Injury

Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats

Peter M. Burch and others

Toxicological Sciences, Volume 150, Issue 1, March 2016, Pages 247–256, https://doi.org/10.1093/toxsci/kfv328

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COVER

Cover

Toxicological Sciences, Volume 150, Issue 1, March 2016, Page i1, https://doi.org/10.1093/toxsci/kfv270

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STANDING MATERIAL

Editorial Board

Toxicological Sciences, Volume 150, Issue 1, March 2016, Page i2, https://doi.org/10.1093/toxsci/kfv271

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Subscriptions

Toxicological Sciences, Volume 150, Issue 1, March 2016, Page i3, https://doi.org/10.1093/toxsci/kfv272

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Table of Contents

Toxicological Sciences, Volume 150, Issue 1, March 2016, Page i4, https://doi.org/10.1093/toxsci/kfv273

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