Volume 143, Issue 2, February 2015

Look Inside ToxSci

From the Editor's Desk, Editorial Highlights, Letter to the Editor

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 229–230, https://doi.org/10.1093/toxsci/kfu263

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Contemporary Review: Air Pollution and Type 2 Diabetes

Air Pollution as a Risk Factor for Type 2 Diabetes

Xiaoquan Rao and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 231–241, https://doi.org/10.1093/toxsci/kfu250

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Review: Mechanism of Acrolein Toxicity

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

Akshata Moghe and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 242–255, https://doi.org/10.1093/toxsci/kfu233

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Forum: Predictive Toxicology in Future Tox II

FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology

Thomas B. Knudsen and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 256–267, https://doi.org/10.1093/toxsci/kfu234

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microRNAs and Drug-Induced Liver Injury

Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-Induced Liver Injury

Julian Krauskopf and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 268–276, https://doi.org/10.1093/toxsci/kfu232

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mRNA Signatures and Hepatic Carcinogenesis

Identification of Specific mRNA Signatures as Fingerprints for Carcinogenesis in Mice Induced by Genotoxic and Nongenotoxic Hepatocarcinogens

Nadine Kossler and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 277–295, https://doi.org/10.1093/toxsci/kfu248

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Urinary Bile Acids in Healthy Subjects

Urinary Bile Acids as Biomarkers for Liver Diseases I. Stability of the Baseline Profile in Healthy Subjects

Sai Praneeth R. Bathena and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 296–307, https://doi.org/10.1093/toxsci/kfu227

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Urinary Bile Acids in Patients with Liver Disease

Urinary Bile Acids as Biomarkers for Liver Diseases II. Signature Profiles in Patients

Sai Praneeth R. Bathena and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 308–318, https://doi.org/10.1093/toxsci/kfu228

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Prediction of Skin Sensitization

Predicting Skin Sensitizer Potency Based on In Vitro Data from KeratinoSens and Kinetic Peptide Binding: Global Versus Domain-Based Assessment

Andreas Natsch and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 319–332, https://doi.org/10.1093/toxsci/kfu229

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Sex Hormone-Binding Globulin and Endocrine Disruption

Human Sex Hormone-Binding Globulin Binding Affinities of 125 Structurally Diverse Chemicals and Comparison with Their Binding to Androgen Receptor, Estrogen Receptor, and α-Fetoprotein

Huixiao Hong and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 333–348, https://doi.org/10.1093/toxsci/kfu231

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Fine Particular Matter Extraction and Lung Responses

Biological Dose Response to PM_2.5: Effect of Particle Extraction Method on Platelet and Lung Responses

Laura S. Van Winkle and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 349–359, https://doi.org/10.1093/toxsci/kfu230

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Novel Protective Compounds in Mouse Model of Parkinson's Disease

Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease

Briana R. De Miranda and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 360–373, https://doi.org/10.1093/toxsci/kfu236

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Tyrosine Kinase Inhibitors and Cardiotoxicity

Downregulation of Stanniocalcin 1 Is Responsible for Sorafenib-Induced Cardiotoxicity

Miko Kawabata and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 374–384, https://doi.org/10.1093/toxsci/kfu235

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Toxicity of Tungsten Carbide-Cobalt Nanoparticles

Human Cell Line-Dependent WC-Co Nanoparticle Cytotoxicity and Genotoxicity: A Key Role of ROS Production

V. Paget and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 385–397, https://doi.org/10.1093/toxsci/kfu238

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Pregnane X and Aryl Hydrocarbon Receptors in Developing Zebrafish

Role of Pregnane X Receptor and Aryl Hydrocarbon Receptor in Transcriptional Regulation of pxr, CYP2, and CYP3 Genes in Developing Zebrafish

Akira Kubota and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 398–407, https://doi.org/10.1093/toxsci/kfu240

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Genotoxic Effects of Diesel Particles in Exposed Workers

Increased Micronucleus, Nucleoplasmic Bridge, and Nuclear Bud Frequencies in the Peripheral Blood Lymphocytes of Diesel Engine Exhaust-Exposed Workers

Xiao Zhang and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 408–417, https://doi.org/10.1093/toxsci/kfu239

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Atrazine and T-Cell Mediated Immune Function

In vitro Exposure to the Herbicide Atrazine Inhibits T Cell Activation, Proliferation, and Cytokine Production and Significantly Increases the Frequency of Foxp3⁺ Regulatory T Cells

Lindsay E. Thueson and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 418–429, https://doi.org/10.1093/toxsci/kfu242

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Protective Role of Cox-1 in Liver Injury

Cyclooxygenase-1 Serves a Vital Hepato-Protective Function in Chemically Induced Acute Liver Injury

Jia Xiao and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 430–440, https://doi.org/10.1093/toxsci/kfu244

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Glucocorticoids and Microvasculature Injury in the Eye

Glucocorticoids Exert Direct Toxicity on Microvasculature: Analysis of Cell Death Mechanisms

Ikram El Zaoui and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 441–453, https://doi.org/10.1093/toxsci/kfu243

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Protective Role of Alpha-Synuclein in Manganese Neurotoxicity

α-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson’s Disease

Dilshan S. Harischandra and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 454–468, https://doi.org/10.1093/toxsci/kfu247

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Polyaromatic Hydrocarbons and Cardiac Toxicity

AHR2-Mediated Transcriptomic Responses Underlying the Synergistic Cardiac Developmental Toxicity of PAHs

Nishad Jayasundara and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 469–481, https://doi.org/10.1093/toxsci/kfu245

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Manganese and Neurogenesis in Brain

Elevated Adult Neurogenesis in Brain Subventricular Zone Following In vivo Manganese Exposure: Roles of Copper and DMT1

Sherleen Fu and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 482–498, https://doi.org/10.1093/toxsci/kfu249

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Carbon Nanotubes and Lung Epithelium Injury

Carbon Nanotubes Induce Apoptosis Resistance of Human Lung Epithelial Cells Through FLICE-Inhibitory Protein

Varisa Pongrakhananon and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 499–511, https://doi.org/10.1093/toxsci/kfu251

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Modeling of Developmental Toxicity of Ethanol

Species Extrapolation of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models to Investigate the Developmental Toxicology of Ethanol Using In vitro to In vivo (IVIVE) Methods

Sheppard A. Martin and others

Toxicological Sciences, Volume 143, Issue 2, February 2015, Pages 512–535, https://doi.org/10.1093/toxsci/kfu246

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COVER

Cover

Toxicological Sciences, Volume 143, Issue 2, February 2015, Page i1, https://doi.org/10.1093/toxsci/kfu278

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STANDING MATERIAL

Editorial Board

Toxicological Sciences, Volume 143, Issue 2, February 2015, Page i2, https://doi.org/10.1093/toxsci/kfu279

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Subscriptions

Toxicological Sciences, Volume 143, Issue 2, February 2015, Page i3, https://doi.org/10.1093/toxsci/kfu280

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Table of Contents

Toxicological Sciences, Volume 143, Issue 2, February 2015, Page i4, https://doi.org/10.1093/toxsci/kfu281

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