Volume 135, Issue 2
October 2013
Cover image
Cover image
Cover illustration. Calcification of the myocardium resulting from mitogen-activated protein kinase kinase (MEK; PD-0325901) or pan-fibroblast growth factor receptor (FGFR; PD-0330361) inhibition reported in the present issue by Yanochko et al. While the FGFR pathway is an appealing strategy for anticancer treatments, the involvement of this receptor in normal cardiovascular development and function poses a significant obstacle.
ISSN 1096-6080
EISSN 1096-0929
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Volume 135, Issue 2, October 2013
EDITORIAL
Editorial: A Toxicological Transition
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 261–262, https://doi.org/10.1093/toxsci/kft173
TOXICOLOGICAL HIGHLIGHT
To Breathe or Not to Breathe: Negative Data on Ozone and Vascular Function in an Established Research Model
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 263–264, https://doi.org/10.1093/toxsci/kft169
CARCINOGENICITY
NF-κB-Mediated Inflammation Leading to EMT via miR-200c Is Involved in Cell Transformation Induced By Cigarette Smoke Extract
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 265–276, https://doi.org/10.1093/toxsci/kft150
ENDOCRINE TOXICOLOGY
EADB: An Estrogenic Activity Database for Assessing Potential Endocrine Activity
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 277–291, https://doi.org/10.1093/toxsci/kft164
ENVIRONMENTAL TOXICOLOGY
Short-Term Exposure to Ozone Does Not Impair Vascular Function or Affect Heart Rate Variability in Healthy Young Men
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 292–299, https://doi.org/10.1093/toxsci/kft157
Epigenetic Modifications of DAPK and p16 Genes Contribute to Arsenic-Induced Skin Lesions and Nondermatological Health Effects
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 300–308, https://doi.org/10.1093/toxsci/kft163
GENETIC TOXICOLOGY
Assessment of the Genotoxic Potential of Azidothymidine in the Comet, Micronucleus, and Pig-a Assay
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 309–316, https://doi.org/10.1093/toxsci/kft148
Genotoxicity Profile of Azidothymidine In Vitro
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 317–327, https://doi.org/10.1093/toxsci/kft149
IMMUNOTOXICOLOGY
Toxicogenomics-Based Identification of Mechanisms for Direct Immunotoxicity
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 328–346, https://doi.org/10.1093/toxsci/kft151
IN VITRO METHOS AND ALTERNATIVES TO ANIMALS
Vitrigel-Eye Irritancy Test Method Using HCE-T Cells
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 347–355, https://doi.org/10.1093/toxsci/kft159
Utility of Rat Liver S9 Fractions to Study Skin-Sensitizing Prohaptens in a Modified KeratinoSens Assay
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 356–368, https://doi.org/10.1093/toxsci/kft160
MOLECULAR TOXICOLOGY
Differential Expression of Long Noncoding RNAs in the Livers of Female B6C3F1 Mice Exposed to the Carcinogen Furan
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 369–379, https://doi.org/10.1093/toxsci/kft153
Serine 9 and Tyrosine 216 Phosphorylation of GSK-3β Differentially Regulates Autophagy in Acquired Cadmium Resistance
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 380–389, https://doi.org/10.1093/toxsci/kft158
Bioinformatic Analysis of 302 Reactive Metabolite Target Proteins. Which Ones Are Important for Cell Death?
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 390–401, https://doi.org/10.1093/toxsci/kft166
Cellular Impedance Assays for Predictive Preclinical Drug Screening of Kinase Inhibitor Cardiovascular Toxicity
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 402–413, https://doi.org/10.1093/toxsci/kft167
RESPIRATORY TOXICOLOGY
Macrophage Solubilization and Cytotoxicity of Indium-Containing Particles In Vitro
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 414–424, https://doi.org/10.1093/toxsci/kft154
An Autonomic Link Between Inhaled Diesel Exhaust and Impaired Cardiac Performance: Insight From Treadmill and Dobutamine Challenges in Heart Failure–Prone Rats
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 425–436, https://doi.org/10.1093/toxsci/kft155
Nitrogen Dioxide and Ultrafine Particles Dominate the Biological Effects of Inhaled Diesel Exhaust Treated by a Catalyzed Diesel Particulate Filter
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 437–450, https://doi.org/10.1093/toxsci/kft162
SAFETY EVALUATION
Pan-FGFR Inhibition Leads to Blockade of FGF23 Signaling, Soft Tissue Mineralization, and Cardiovascular Dysfunction
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 451–464, https://doi.org/10.1093/toxsci/kft161
SYSTEMS TOXICOLOGY
Toxicogenomic Evaluation of Long-term Hepatic Effects of TCDD in Immature, Ovariectomized C57BL/6 Mice
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 465–475, https://doi.org/10.1093/toxsci/kft156
BIOTRANSFORMATION AND TOXICOKINETICS
Transcriptional Suppression of CYP2A13 Expression by Lipopolysaccharide in Cultured Human Lung Cells and the Lungs of a CYP2A13-Humanized Mouse Model
Toxicological Sciences, Volume 135, Issue 2, October 2013, Pages 476–485, https://doi.org/10.1093/toxsci/kft165
STANDING MATERIAL
Editorial_Board
Toxicological Sciences, Volume 135, Issue 2, October 2013, Page NP, https://doi.org/10.1093/toxsci/kft057
Subscriptions
Toxicological Sciences, Volume 135, Issue 2, October 2013, Page NP, https://doi.org/10.1093/toxsci/kft058
Table_of_Contents
Toxicological Sciences, Volume 135, Issue 2, October 2013, Page NP, https://doi.org/10.1093/toxsci/kft059
