Volume 125, Issue 1, January 2012

Editorial

EDITORIAL

Michael L. Cunningham

Toxicological Sciences, Volume 125, Issue 1, January 2012, Page 1, https://doi.org/10.1093/toxsci/kfr294

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Forum

Fifty Years of “the Pill”: Risk Reduction and Discovery of Benefits Beyond Contraception, Reflections, and Forecast

Kristina D. Chadwick and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 2–9, https://doi.org/10.1093/toxsci/kfr242

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CARCINOGENICITY

Cadmium Increases HIF-1 and VEGF Expression through ROS, ERK, and AKT Signaling Pathways and Induces Malignant Transformation of Human Bronchial Epithelial Cells

Yi Jing and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 10–19, https://doi.org/10.1093/toxsci/kfr256

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Overabundance of Putative Cancer Stem Cells in Human Skin Keratinocyte Cells Malignantly Transformed by Arsenic

Yang Sun and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 20–29, https://doi.org/10.1093/toxsci/kfr282

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Formation of 1,2:3,4-Diepoxybutane-Specific Hemoglobin Adducts in 1,3-Butadiene Exposed Workers

Gunnar Boysen and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 30–40, https://doi.org/10.1093/toxsci/kfr272

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ENVIRONMENTAL TOXICOLOGY

Comparative Metabolomic and Genomic Analyses of TCDD-Elicited Metabolic Disruption in Mouse and Rat Liver

Agnes L. Forgacs and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 41–55, https://doi.org/10.1093/toxsci/kfr262

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Activation of TRPC Cationic Channels by Mercurial Compounds Confers the Cytotoxicity of Mercury Exposure

Shang-Zhong Xu and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 56–68, https://doi.org/10.1093/toxsci/kfr268

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Promotion of Hepatocarcinogenesis by Perfluoroalkyl Acids in Rainbow Trout

Abby D. Benninghoff and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 69–78, https://doi.org/10.1093/toxsci/kfr267

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Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action

Chad M. Thompson and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 79–90, https://doi.org/10.1093/toxsci/kfr280

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TCDD Disrupts Hypural Skeletogenesis during Medaka Embryonic Development

Wu Dong and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 91–104, https://doi.org/10.1093/toxsci/kfr284

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IMMUNOTOXICOLOGY

Evaluation of Furfuryl Alcohol Sensitization Potential Following Dermal and Pulmonary Exposure: Enhancement of Airway Responsiveness

Jennifer Franko and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 105–115, https://doi.org/10.1093/toxsci/kfr271

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Chronic Nod2 Stimulation Potentiates Activating Transcription Factor 3 and Paradoxical Superinduction of Epithelial Proinflammatory Chemokines by Mucoactive Ribotoxic Stressors via RNA-Binding Protein Human Antigen R

Seong Hwan Park and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 116–125, https://doi.org/10.1093/toxsci/kfr270

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Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha

Jingtao Lu and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 126–133, https://doi.org/10.1093/toxsci/kfr266

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Low-Dose Inorganic Mercury Increases Severity and Frequency of Chronic Coxsackievirus-Induced Autoimmune Myocarditis in Mice

Jennifer F. Nyland and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 134–143, https://doi.org/10.1093/toxsci/kfr264

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The Dysregulation of the Monocyte/Macrophage Effector Function Induced by Isopropanol Is Mediated by the Defective Activation of Distinct Members of the AP-1 Family of Transcription Factors

Damien Carignan and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 144–156, https://doi.org/10.1093/toxsci/kfr283

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IN VITRO METHODS AND ALTERNATIVES TO ANIMALS

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

Barbara A. Wetmore and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 157–174, https://doi.org/10.1093/toxsci/kfr254

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Connexin43 Signaling Contributes to Spontaneous Apoptosis in Cultures of Primary Hepatocytes

Mathieu Vinken and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 175–186, https://doi.org/10.1093/toxsci/kfr277

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MOLECULAR TOXICOLOGY

Phosphorous Dysregulation Induced by MEK Small Molecule Inhibitors in the Rat Involves Blockade of FGF-23 Signaling in the Kidney

Dolores Diaz and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 187–195, https://doi.org/10.1093/toxsci/kfr263

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NEUROTOXICOLOGY

Delayed Reduction of Hippocampal Synaptic Transmission and Spines Following Exposure to Repeated Subclinical Doses of Organophosphorus Pesticide in Adult Mice

Haley E. Speed and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 196–208, https://doi.org/10.1093/toxsci/kfr253

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The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity

David Godefroy and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 209–218, https://doi.org/10.1093/toxsci/kfr252

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Standardized Extracts of Bacopa monniera Protect Against MPP⁺- and Paraquat-Induced Toxicity by Modulating Mitochondrial Activities, Proteasomal Functions, and Redox Pathways

Manjeet Singh and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 219–232, https://doi.org/10.1093/toxsci/kfr255

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PAH Particles Perturb Prenatal Processes and Phenotypes: Protection from Deficits in Object Discrimination Afforded by Dampening of Brain Oxidoreductase Following In Utero Exposure to Inhaled Benzo(a)pyrene

Zhu Li and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 233–247, https://doi.org/10.1093/toxsci/kfr261

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Early Postnatal Benzo(a)pyrene Exposure in Sprague-Dawley Rats Causes Persistent Neurobehavioral Impairments that Emerge Postnatally and Continue into Adolescence and Adulthood

Chengzhi Chen and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 248–261, https://doi.org/10.1093/toxsci/kfr265

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REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Aberrant Ligand-Induced Activation of G Protein–Coupled Estrogen Receptor 1 (GPER) Results in Developmental Malformations During Vertebrate Embryogenesis

B. Sumith Jayasinghe and David C. Volz

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 262–273, https://doi.org/10.1093/toxsci/kfr269

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Cigarette Smoke Exposure Leads to Follicle Loss via an Alternative Ovarian Cell Death Pathway in a Mouse Model

Anne Marie Gannon and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 274–284, https://doi.org/10.1093/toxsci/kfr279

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Risk assessment

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

Giel Hendriks and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 285–298, https://doi.org/10.1093/toxsci/kfr281

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SAFETY EVALUATION

Nonclinical Evaluation of GMA161—An Antihuman CD16 (FcγRIII) Monoclonal Antibody for Treatment of Autoimmune Disorders in CD16 Transgenic Mice

Meghan M. Flaherty and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 299–309, https://doi.org/10.1093/toxsci/kfr278

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TRANSLATIONAL RESEARCH IN TOXICOLOGY

The Cutaneous Lesions of Dioxin Exposure: Lessons from the Poisoning of Victor Yushchenko

Jean-Hilaire Saurat and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 310–317, https://doi.org/10.1093/toxsci/kfr223

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Letters to Editor

Report of Very Low Real-World Exposure to Bisphenol A is Unwarranted Based on a Lack of Data and Flawed Assumptions

Frederick S. vom Saal and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 318–320, https://doi.org/10.1093/toxsci/kfr273

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Adhering to Fundamental Principles of Biomonitoring, BPA Pharmacokinetics, and Mass Balance Is No “Flaw”

Justin G. Teeguarden and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 321–325, https://doi.org/10.1093/toxsci/kfr275

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Corrigendum

Corrigendum

Toxicological Sciences, Volume 125, Issue 1, January 2012, Page 326, https://doi.org/10.1093/toxsci/kfr308

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Standing Materials

TABLE OF CONTENTS

Toxicological Sciences, Volume 125, Issue 1, January 2012, Page NP, https://doi.org/10.1093/toxsci/kfr322

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COVER

COVER

Toxicological Sciences, Volume 125, Issue 1, January 2012, Page NP, https://doi.org/10.1093/toxsci/kfr323

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Standing Materials

EDITORIAL BOARD

Toxicological Sciences, Volume 125, Issue 1, January 2012, Page NP, https://doi.org/10.1093/toxsci/kfr324

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SUBSCRIPTIONS

Toxicological Sciences, Volume 125, Issue 1, January 2012, Page NP, https://doi.org/10.1093/toxsci/kfr325

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