Volume 118, Issue 1, November 2010

Editorial

A Quarter-Century of Immunotoxicology: Looking Back, Looking Forward

Robert V. House and Mary J. Selgrade

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 1–3, https://doi.org/10.1093/toxsci/kfq242

• Extract
• View article

TOXICOLOGICAL HIGHLIGHT

The Use of Cultured Amphibian Thyroid Glands to Detect Thyroid Hormone Disruptors

Martin van den Berg

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 4–6, https://doi.org/10.1093/toxsci/kfq231

• Extract
• View article

Review

Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity

Patrick J. Shaw and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 7–18, https://doi.org/10.1093/toxsci/kfq168

• Abstract
• View article

BIOMARKERS OF TOXICITY

Transcriptomic Profile Indicative of Immunotoxic Exposure: In Vitro Studies in Peripheral Blood Mononuclear Cells

Kevin Hochstenbach and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 19–30, https://doi.org/10.1093/toxsci/kfq239

• Abstract
• View article

CARCINOGENICITY

Toxicogenomics Applied to In Vitro Carcinogenicity Testing with Balb/c 3T3 Cells Revealed a Gene Signature Predictive of Chemical Carcinogens

Astrid Rohrbeck and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 31–41, https://doi.org/10.1093/toxsci/kfq246

• Abstract
• View article
• Supplementary data

ENDOCRINE TOXICOLOGY

HIGHLIGHTED ARTICLE:

Inhibition of Thyroid Hormone Release from Cultured Amphibian Thyroid Glands by Methimazole, 6-Propylthiouracil, and Perchlorate

Michael W. Hornung and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 42–51, https://doi.org/10.1093/toxsci/kfq166

• Abstract
• View article
• Supplementary data

Upregulation of Peripubertal Rat Leydig Cell Steroidogenesis Following 24 h In Vitro and In Vivo Exposure to Atrazine

Kristina Pogrmic-Majkic and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 52–60, https://doi.org/10.1093/toxsci/kfq227

• Abstract
• View article

Prochloraz-induced Oocyte Maturation in Rainbow Trout (Oncorhynchus mykiss), a Molecular and Functional Analysis

Hélène Rime and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 61–70, https://doi.org/10.1093/toxsci/kfq255

• Abstract
• View article

GENETIC TOXICOLOGY

High-Content Micronucleus Assay in Genotoxicity Profiling: Initial-Stage Development and Some Applications in the Investigative/Lead-Finding Studies in Drug Discovery

Madhu S. Mondal and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 71–85, https://doi.org/10.1093/toxsci/kfq181

• Abstract
• View article
• Supplementary data

IMMUNOTOXICOLOGY

Induction of the Aryl Hydrocarbon Receptor–Responsive Genes and Modulation of the Immunoglobulin M Response by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Primary Human B Cells

Haitian Lu and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 86–97, https://doi.org/10.1093/toxsci/kfq234

• Abstract
• View article

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Impairs Stable Establishment of Oral Tolerance in Mice

Stefanie Chmill and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 98–107, https://doi.org/10.1093/toxsci/kfq232

• Abstract
• View article

The Role of CaMKII in Calcium-Activated Death Pathways in Bone Marrow B Cells

Stephanie L. Bissonnette and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 108–118, https://doi.org/10.1093/toxsci/kfq256

• Abstract
• View article
• Supplementary data

IN VITRO METHODS AND ALTERNATIVES TO ANIMALS

Iron Potentiates Acetaminophen-Induced Oxidative Stress and Mitochondrial Dysfunction in Cultured Mouse Hepatocytes

Mi Sun Moon and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 119–127, https://doi.org/10.1093/toxsci/kfq230

• Abstract
• View article

An Information-Rich Alternative, Chemicals Testing Strategy Using a High Definition Toxicogenomics and Zebrafish (Danio rerio) Embryos

Ashley D. Sawle and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 128–139, https://doi.org/10.1093/toxsci/kfq237

• Abstract
• View article
• Supplementary data

NANOTOXICOLOGY

Small Amounts of Zinc from Zinc Oxide Particles in Sunscreens Applied Outdoors Are Absorbed through Human Skin

Brian Gulson and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 140–149, https://doi.org/10.1093/toxsci/kfq243

• Abstract
• View article
• Supplementary data

NEUROTOXICOLOGY

Polychlorinated Biphenyls and Polybrominated Diphenyl Ethers Alter Striatal Dopamine Neurochemistry in Synaptosomes from Developing Rats in an Additive Manner

Anne Dreiem and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 150–159, https://doi.org/10.1093/toxsci/kfq229

• Abstract
• View article
• Supplementary data

Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells

William J. Trickler and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 160–170, https://doi.org/10.1093/toxsci/kfq244

• Abstract
• View article

Synergistic Inhibition of Glycinergic Transmission In Vitro and In Vivo by Flavonoids and Strychnine

Karim Raafat and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 171–182, https://doi.org/10.1093/toxsci/kfq245

• Abstract
• View article

Activation and Potentiation of Human GABA_A Receptors by Non-Dioxin–Like PCBs Depends on Chlorination Pattern

Elsa C. Antunes Fernandes and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 183–190, https://doi.org/10.1093/toxsci/kfq257

• Abstract
• View article
• Supplementary data

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Progressive Mitochondrial Compromise in Brains and Livers of Primates Exposed In Utero to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

Rao L. Divi and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 191–201, https://doi.org/10.1093/toxsci/kfq235

• Abstract
• View article

Comparison of the Toxicity of Smoke from Conventional and Harm Reduction Cigarettes Using Human Embryonic Stem Cells

Sabrina Lin and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 202–212, https://doi.org/10.1093/toxsci/kfq241

• Abstract
• View article
• Supplementary data

TCDD Induced Pericardial Edema and Relative COX-2 Expression in Medaka (Oryzias Latipes) Embryos

Wu Dong and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 213–223, https://doi.org/10.1093/toxsci/kfq254

• Abstract
• View article

Risk assessment

Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8-Pentachlorodibenzofuran

Robert A. Budinsky and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 224–235, https://doi.org/10.1093/toxsci/kfq238

• Abstract
• View article
• Supplementary data

SAFETY EVALUATION

The Phototoxicity of Fluvastatin, an HMG-CoA Reductase Inhibitor, Is Mediated by the formation of a Benzocarbazole-Like Photoproduct

Giampietro Viola and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 236–250, https://doi.org/10.1093/toxsci/kfq228

• Abstract
• View article
• Supplementary data

A Novel Framework for Predicting In Vivo Toxicities from In Vitro Data Using Optimal Methods for Dense and Sparse Matrix Reordering and Logistic Regression

Peter A. DiMaggio and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 251–265, https://doi.org/10.1093/toxsci/kfq233

• Abstract
• View article
• Supplementary data

Modeling Bone Marrow Toxicity Using Kinase Structural Motifs and the Inhibition Profiles of Small Molecular Kinase Inhibitors

Andrew J. Olaharski and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 266–275, https://doi.org/10.1093/toxsci/kfq258

• Abstract
• View article
• Supplementary data

SYSTEMS TOXICOLOGY

Pharmacologic Targeting or Genetic Deletion of Mitochondrial Cyclophilin D Protects from NSAID-Induced Small Intestinal Ulceration in Mice

Amanda LoGuidice and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 276–285, https://doi.org/10.1093/toxsci/kfq226

• Abstract
• View article

Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice

Anna K. Kopec and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 286–297, https://doi.org/10.1093/toxsci/kfq236

• Abstract
• View article
• Supplementary data

TIM2 Gene Deletion Results in Susceptibility to Cisplatin-Induced Kidney Toxicity

Aparna Krishnamoorthy and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 298–306, https://doi.org/10.1093/toxsci/kfq240

• Abstract
• View article

Discriminating between Different Acute Chemical Toxicities via Changes in the Daphnid Metabolome

Nadine S. Taylor and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 307–317, https://doi.org/10.1093/toxsci/kfq247

• Abstract
• View article
• Supplementary data

Letters to the Editor

Cobalt-Induced Lung Injury and Hypoxia-Inducible Factor 1α

Ken-ichiro Inoue and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Page 318, https://doi.org/10.1093/toxsci/kfq248

• Extract
• View article

HIF1α, Acute Cobalt Toxicity, and Lung Inflammation—Reply

John J. LaPres

Toxicological Sciences, Volume 118, Issue 1, November 2010, Page 319, https://doi.org/10.1093/toxsci/kfq249

• Extract
• View article

Standing Materials

CONTENTS

Toxicological Sciences, Volume 118, Issue 1, November 2010, Page NP, https://doi.org/10.1093/toxsci/kfq298

• View article

COVER

Cover

Toxicological Sciences, Volume 118, Issue 1, November 2010, Page NP, https://doi.org/10.1093/toxsci/kfq299

• View article

Standing Materials

Editorial Board

Toxicological Sciences, Volume 118, Issue 1, November 2010, Page NP, https://doi.org/10.1093/toxsci/kfq300

• View article

Subscriptions

Toxicological Sciences, Volume 118, Issue 1, November 2010, Page NP, https://doi.org/10.1093/toxsci/kfq301

• View article