Volume 100, Issue 1, November 2007

Editorial

Paraquat: The Red Herring of Parkinson's Disease Research

Gary Wright Miller

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 1–2, https://doi.org/10.1093/toxsci/kfm223

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PROFILES IN TOXICOLOGY

Emil Alvin Pfitzer

R. Michael McClain and Bernard M. Wagner

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 3–4, https://doi.org/10.1093/toxsci/kfm237

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TOXICOLOGICAL HIGHLIGHT

Bringing Biomarkers to the Masses: An Elegant Approach to Discover Potential Biomarkers of Vascular Injury

Robert Francis Stachlewitz

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 5–6, https://doi.org/10.1093/toxsci/kfm228

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Review

The Dynamic Epigenome and its Implications in Toxicology

Moshe Szyf

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 7–23, https://doi.org/10.1093/toxsci/kfm177

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Forum

Recent Developments in the Risk Assessment of Potentially Genotoxic Impurities in Pharmaceutical Drug Substances

Charles D. N. Humfrey

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 24–28, https://doi.org/10.1093/toxsci/kfm173

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Inclusion of Biomarkers for Detecting Perturbations in the Heart and Lung and Lipid/Carbohydrate Metabolism in National Toxicology Program Studies

June K. Dunnick and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 29–35, https://doi.org/10.1093/toxsci/kfm113

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BIOTRANSFORMATION AND TOXICOKINETICS

Glutathione-Dependent Reduction of Arsenate by Glycogen Phosphorylase—A Reaction Coupled to Glycogenolysis

Balázs Németi and Zoltán Gregus

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 36–43, https://doi.org/10.1093/toxsci/kfm211

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Glutathione-Dependent Reduction of Arsenate by Glycogen Phosphorylase—Responsiveness to Endogenous and Xenobiotic Inhibitors

Zoltán Gregus and Balázs Németi

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 44–53, https://doi.org/10.1093/toxsci/kfm212

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ENDOCRINE TOXICOLOGY

Evaluation of the Antiandrogenic Effects of Flutamide, DDE, and Linuron in the Weanling Rat Assay Using Organ Weight, Histopathological, and Proteomic Approaches

Helen Tinwell and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 54–65, https://doi.org/10.1093/toxsci/kfm208

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ENVIRONMENTAL TOXICOLOGY

Characterization of Arecoline-Induced Effects on Cytotoxicity in Normal Human Gingival Fibroblasts by Global Gene Expression Profiling

Shang-Lun Chiang and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 66–74, https://doi.org/10.1093/toxsci/kfm201

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Exposure to Arsenic at Levels Found in U.S. Drinking Water Modifies Expression in the Mouse Lung

Angeline S. Andrew and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 75–87, https://doi.org/10.1093/toxsci/kfm200

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GENETIC TOXICOLOGY

Quinoid Metabolites of 4-Monochlorobiphenyl Induce Gene Mutations in Cultured Chinese Hamster V79 Cells

Markus Alexander Zettner and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 88–98, https://doi.org/10.1093/toxsci/kfm204

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IMMUNOTOXICOLOGY

Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice

Aimen K. Farraj and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 99–108, https://doi.org/10.1093/toxsci/kfm194

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IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Thimerosal-Induced Apoptosis in Human SCM1 Gastric Cancer Cells: Activation of p38 MAP Kinase and Caspase-3 Pathways without Involvement of [Ca²⁺]_i Elevation

Shiuh-Inn Liu and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 109–117, https://doi.org/10.1093/toxsci/kfm205

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NEUROTOXICOLOGY

Altered Muscarinic Acetylcholine Receptor Subtype Binding in Neonatal Rat Brain following Exposure to Chlorpyrifos or Methyl Parathion

Shirley X. Guo-Ross and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 118–127, https://doi.org/10.1093/toxsci/kfm195

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Concentration-Dependent Binding of Chlorpyrifos Oxon to Acetylcholinesterase

Lester G. Sultatos

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 128–135, https://doi.org/10.1093/toxsci/kfm197

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Aging Pathways for Organophosphate-Inhibited Human Butyrylcholinesterase, Including Novel Pathways for Isomalathion, Resolved by Mass Spectrometry

He Li and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 136–145, https://doi.org/10.1093/toxsci/kfm215

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Quantitative Comparisons of the Acute Neurotoxicity of Toluene in Rats and Humans

Vernon A. Benignus and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 146–155, https://doi.org/10.1093/toxsci/kfm203

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Proteomic Analysis of Rat Striatal Synaptosomes during Acrylamide Intoxication at a Low Dose Rate

David S. Barber and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 156–167, https://doi.org/10.1093/toxsci/kfm210

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REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Matrix Metalloproteinase-13 Is Required for Zebra fish (Danio rerio) Development and Is a Target for Glucocorticoids

Jedd Michael Hillegass and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 168–179, https://doi.org/10.1093/toxsci/kfm192

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Role of AHR2 in the Expression of Novel Cytochrome P450 1 Family Genes, Cell Cycle Genes, and Morphological Defects in Developing Zebra Fish Exposed to 3,3′,4,4′,5-Pentachlorobiphenyl or 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Maria E. Jönsson and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 180–193, https://doi.org/10.1093/toxsci/kfm207

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Effects of Altered Food Intake during Pubertal Development in Male and Female Wistar Rats

Susan C. Laws and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 194–202, https://doi.org/10.1093/toxsci/kfm219

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RESPIRATORY TOXICOLOGY

Pulmonary and Systemic Immune Response to Inhaled Multiwalled Carbon Nanotubes

Leah A. Mitchell and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 203–214, https://doi.org/10.1093/toxsci/kfm196

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High Dietary Inorganic Phosphate Affects Lung through Altering Protein Translation, Cell Cycle, and Angiogenesis in Developing Mice

Hua Jin and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 215–223, https://doi.org/10.1093/toxsci/kfm202

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Risk assessment

An Adaptable Internal Dose Model for Risk Assessment of Dietary and Soil Dioxin Exposures in Young Children

Brent D. Kerger and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 224–237, https://doi.org/10.1093/toxsci/kfm199

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SAFETY EVALUATION

Investigation of the Molecular Mechanisms Preceding PDE4 Inhibitor-Induced Vasculopathy in Rats: Tissue Inhibitor of Metalloproteinase 1, a Potential Predictive Biomarker

Nicolas Daguès and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 238–247, https://doi.org/10.1093/toxsci/kfm161

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Nonclinical Safety Evaluation of Muraglitazar, a Novel PPARα/γ Agonist

Crystal R. Waites and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 248–258, https://doi.org/10.1093/toxsci/kfm193

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SYSTEMS TOXICOLOGY

Lipopolysaccharide and Trovafloxacin Coexposure in Mice Causes Idiosyncrasy-Like Liver Injury Dependent on Tumor Necrosis Factor-Alpha

Patrick J. Shaw and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 259–266, https://doi.org/10.1093/toxsci/kfm218

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The Role of Tumor Necrosis Factor Alpha in Lipopolysaccharide/Ranitidine-Induced Inflammatory Liver Injury

Francis F. Tukov and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 267–280, https://doi.org/10.1093/toxsci/kfm209

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Muscarinic Receptor Dysfunction Induced by Exposure to Low Levels of Soman Vapor

Paul A. Dabisch and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 281–289, https://doi.org/10.1093/toxsci/kfm213

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Toxicogenomics of Drug-Induced Hemolytic Anemia by Analyzing Gene Expression Profiles in the Spleen

Masatomo Rokushima and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 290–302, https://doi.org/10.1093/toxsci/kfm216

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Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials

Debamitra Dutta and others

Toxicological Sciences, Volume 100, Issue 1, November 2007, Pages 303–315, https://doi.org/10.1093/toxsci/kfm217

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