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Scott Lucyk, Daniel Vilensky, Patrick T. Fok, Lewis S. Nelson, Reactivation of Plasma Butyrylcholinesterase by Pralidoxime Chloride in Patients Poisoned by WHO Class II Toxicity Organophosphorus Insecticides, Toxicological Sciences, Volume 138, Issue 2, April 2014, Page 482, https://doi.org/10.1093/toxsci/kft337
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To the Editor,
We commend Eddleston and coworkers for investigating the utility of butyrylcholinesterase (BuChE) activity as a surrogate marker for pralidoxime effectiveness in organophosphate (OP) poisoned patients (Konickx et al., 2013). Although the authors analyzed data from two of their previous studies (Eddleston et al., 2005, 2009), only the randomized controlled trial data demonstrated significant changes in BuChE with pralidoxime treatment. Based on the data presented in Figure 3 (Konickx et al., 2013), pralidoxime administration improves BuChE within the first hour following ingestion of diethoxy OP. Also, patients administered pralidoxime rapidly following ingestion had an increase in BuChE activity compared to those with late administration (Fig. 4). Although the group analysis did not show improved mortality or reduced need for intubation (Eddleston et al., 2009), we question whether analysis of a subgroup of patients who were both administered pralidoxime early and had evidence of reactivation of BuChE would have shown an improved clinical outcome. It would also have been useful to know whether the subsequent decrease in BuChE after initial rise following pralidoxime administration correlated with either worsening clinical status or the need for other treatment interventions.
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