Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

Daniel M. Rotroff, Barbara A. Wetmore, David J. Dix, Stephen S. Ferguson, Harvey J. Clewell, Keith A. Houck, Edward L. LeCluyse, Melvin E. Andersen, Richard S. Judson, Cornelia M. Smith, Mark A. Sochaski, Robert J. Kavlock, Frank Boellmann, Matthew T. Martin, David M. Reif, John F. Wambaugh, and Russell S. Thomas

The authors regret that there were two errors associated with our publication.

  1. The exposure estimate for pyrithiobac-sodium was 0.00012mg/kg/day instead of the reported 0.0012mg/kg/day. This affects text throughout the publication that erroneously states that in vitro biological activity for pyrithiobac-sodium was observed at oral equivalent doses at or below human exposure estimates.

  2. The 5th sentence in Figure 3 describing the box and whisker plots should read: “The distribution of the oral equivalent doses is depicted as a box plot where the lower and upper edges of the boxes represent the 25th and 75th percentiles, and the whiskers represent the range of values 1.5 times the interquartile range below or above the 25th and 75th percentiles, respectively. In those instances where the lowest or highest value for that chemical-assay combination does not exceed the whisker, the whisker is set to that value.”

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