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DAVID P. McFADDEN, GARY P. CARLSON, ROGER P. MAICKEL, The Role of Methemoglobin in Acute Butyl Nitrite Toxicity in Mice, Fundamental and Applied Toxicology, Volume 1, Issue 6, November 1981, Pages 448–451, https://doi.org/10.1093/toxsci/1.6.448
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Abstract
The Role of Methemoglobin in Acute Butyl Nitrite Toxicity in Mice. McFadden, David P., Carlson, Gary P. and Maickel, Roger P. (1981). Fundam. Appl. Toxicol. 1:448–451. When mice were exposed to butyl nitrites in an inhalation chamber, a significant level of methemoglobinemia is produced. The potency order for methemoglobin production of the four butyl nitrites (n-, iso-, sec-, tert-) is the same as that of their lethal concentrations (LCSO values) and parallels the ability of the agents to cause methemoglobin formation in mouse erythrocytes in vitro. Pretreatment with a single dose of methylene blue prevents the methemoglobin formation and protects against the lethality of the butyl nitrites.
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