Abstract

The Role of Methemoglobin in Acute Butyl Nitrite Toxicity in Mice. McFadden, David P., Carlson, Gary P. and Maickel, Roger P. (1981). Fundam. Appl. Toxicol. 1:448–451. When mice were exposed to butyl nitrites in an inhalation chamber, a significant level of methemoglobinemia is produced. The potency order for methemoglobin production of the four butyl nitrites (n-, iso-, sec-, tert-) is the same as that of their lethal concentrations (LCSO values) and parallels the ability of the agents to cause methemoglobin formation in mouse erythrocytes in vitro. Pretreatment with a single dose of methylene blue prevents the methemoglobin formation and protects against the lethality of the butyl nitrites.

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