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Jennifer R Goldschmied, Hengyi Rao, David Dinges, Namni Goel, John A Detre, Mathias Basner, Yvette I Sheline, Michael E Thase, Philip R Gehrman, 0886 Recovery Sleep Significantly Decreases BDNF In Major Depression Following Therapeutic Sleep Deprivation, Sleep, Volume 42, Issue Supplement_1, April 2019, Page A356, https://doi.org/10.1093/sleep/zsz067.884
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Abstract
Sleep deprivation results in rapid antidepressant effects in 50% of individuals with Major Depressive Disorder (MDD). However, this antidepressant effect is typically reversed by recovery sleep. More recently, it has been shown that BDNF, a key component in regulating neuroplasticity, is both reduced in MDD, and increases following treatment including therapeutic sleep deprivation. What remains to be established is if changes in BDNF show a similar pattern of decrease following recovery sleep. Therefore, the aim of this study was the examine serum BDNF in individuals with and without MDD before and after therapeutic sleep deprivation.
16 individuals with MDD (14 female; mean age=34.06, SD=10.16), and 7 healthy controls (HC) (2 female; mean age=38.14, SD=9.56) participated in the study. Participants completed a 5 day/4 night protocol consisting of adaptation, baseline, total sleep deprivation, and recovery phases. Serum BDNF was collected at 7 am following adaptation sleep, during sleep deprivation, and following recovery sleep. Mood was assessed using the modified Hamilton Rating Scale for Depression (HAM-D) each day at 10:30am.
Results from repeated measures ANOVA revealed a significant condition (Post Adaptation, During Sleep Deprivation, Post Recovery) by group (HC, MDD) interaction, F (2, 42) = 4.88, p<.05. Post-hoc tests revealed that individuals with MDD showed a significant decrease in BDNF following recovery sleep, t(15)=2.09, p<.05, while HC did not. Means for sleep deprivation BDNF were 4771.13 ng/ml (SD:4689.49) for MDD and 2571.18 ng/ml (SD:2679.67) for HC while recovery BDNF were 3577.48 ng/ml (SD:3208.20) for MDD and 6075.49 ng/ml (SD:7792.01) for HC. Correlational analysis also revealed that the higher the initial HAM-D score, the lower the BDNF level was following recovery, r=-.515, p<.05.
The results of this study demonstrate that following recovery sleep, BDNF significantly decreases in those with MDD. As the improvements in mood associated with therapeutic sleep deprivation have been shown to decrease following recovery sleep, these results may suggest that changes in neuroplasticity mediate the relationship between sleep and mood in MDD.
T32HL007713-24 (JG), R01MH107571-03 (PG)
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