... the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Topiramate has been found to be effective in reducing alcohol use...

...-publication-reuse-rights ) polycystic ovary syndrome weight loss topiramate metformin obesity diet Foundation for Research and Education Excellence In a recent issue of The Journal of Clinical Endocrinology and Metabolism, Marchesan et al ( 1 ) reported on a randomized clinical trial...

.... Abstract Context Polycystic ovary syndrome (PCOS) is often linked with obesity, and weight management can improve endocrine and cardiometabolic features. Objective This work aimed to evaluate the effects of adding topiramate (TPM) to metformin (MTF) on weight control and hormonal and metabolic...

... in existing classifications, (2) known combinations across different organ systems not previously grouped, (3) unknown combinations not previously grouped, and (4) malformations seemingly standing on their own. Testing the approach with valproate and topiramate identified expected signals and a signal...

...Nassima A-D Tiouririne; Tevfik Kalelioglu; Chamindi Seneviratne; Xin-Qun Wang Alcohol use disorder (AUD) continues to be a predominant problem in our society that affects millions of Americans. Topiramate (TPM), an antiepileptic drug, has had consistent positive results in treating individuals...

... swelling and brain water intake. An anti-epileptic drug that blocks AQP4 function (topiramate) was used to prevent cytotoxic edema in models of BM. Results Radiation-induced astrocytic swelling and transient upregulation of AQP4 occurred within the first 24 hours following radiation. Topiramate...

... reduced the amount of activated microglial cells ( Dambach et al., 2014 ). In another in vitro study, metabolic effects of GBP, CBZ, lamotrigine (LTG), topiramate (TPM), oxcarbazepine, tiagabine, and LEV on primary astrocytes were demonstrated ( Pavone and Cardile 2003 ). LTG [3,-5-diamino-6-(2,3...

...Maria Charbonneau; Courtney Doyle-Campbell; Corey Laskey; Kam Capoccia Promptly after the initiation of topiramate, the patient lost her ability to taste carbonation in all beverages, including soda, seltzer, and beer. The first beverage she tried following initiation of topiramate 25 mg by mouth...

... demonstrated efficacy of topiramate in SRED. We conducted a placebo-controlled randomized clinical trial of topiramate to assess efficacy in SRED. Methods Thirty-four participants with an ICSD-2/ICSD-3 diagnosis of SRED with >6 months of symptoms and ≥3 sleep-related eating episodes per week were...

... administered with one specific agonist or antagonist of the GABA_A receptor (topiramate or bicuculline), in the setting of presence or depletion of monocytes/macrophages. Our data showed that within the first 2 weeks after MI, when monocytes/macrophages dominated, in contrast with bicuculline...

... ( 2010 ) Topiramate in the new generation of drugs: efficacy in the treatment of alcoholic patients . Curr Pharm Des 16 : 2103 – 2112...

...Henry R. Kranzler; Stephen Armeli; Richard Feinn; Howard Tennen; Joel Gelernter; Jonathan Covault Kranzler et al. (2014) provide a detailed description of the methods employed in this 12-week, parallel-grouped, placebo-controlled trial of topiramate in heavy drinkers. All patients received...

..., radical prostatectomy, and prostate radiation. Topiramate (TPM) is a new antiepileptic drug with recognized efficacy in neuropathic pain. Aim The study is aimed to evaluate TPM efficacy in ejaculation pain. Methods Following a spinal cord injury, a 53-year-old man was referred to our institute...

...David H. Winslow; Charles H. Bowden; Karen P. DiDonato; Pamela A. McCullough The investigational combination therapy, phentermine 15 mg plus extended-release topiramate 92 mg, has previously demonstrated weight loss in excess of 10% of body weight in obese individuals with weight-related...

... of action for the treatment of biologically complex disorders may be more effective when used together. Combination therapy is a common approach in many headache centers [15–17] . Little is known about the long-term efficacy, safety, and side effects of topiramate and flunarizine for migraine prophylaxis...

...April D. Miller; Valerie M. Prost; P. Brandon Bookstaver; Kenneth J. Gaines This case is unique in that myoclonus occurred with a standard dosage of topiramate used for migraine prophylaxis (i.e., 50–100 mg daily). There was no apparent factor such as infection, myoclonus, epilepsy, multiple...

.... The patient was compliant with his medications, since his group home assisted with medication administration. His oral medications included topiramate 300 mg twice daily, carbamazepine 200 mg thrice daily, olanzapine 20 mg at bedtime, quetiapine 200 mg twice daily, guanfacine 1 mg twice daily...

... of Health-System Pharmacists, Inc. All rights reserved. 2008 Upon evaluation of previous case reports, it is evident that careful consideration should be taken upon prescribing and monitoring topiramate therapy. Practitioners should obtain a detailed history from the patient and identify any possible risk...

...: 30 mg/kg, IP, N = 10/group [ 27–30 ]; Baclofen: 3 mg/kg, IP, N = 10/group [ 31, 32 ]; Mexiletine: 30 mg/kg, IP, N = 10/group [ 33–35 ]; Oxcarbazepine: 100 mg/kg, PO, N = 8/group [ 36,37 ]; Tramadol: 20 mg/kg, IP, N = 10/group [ 38,39 ]; and NMED-126: 30 mg/kg, PO, N = 10/group [ 17 ]. Topiramate...

...: 336-574-8000; Fax: 336-574-8008; E-mail: [email protected] . The safety data from patients who participated in four randomized, double-blind, placebo-controlled, parallel-group topiramate migraine prevention studies were pooled for these analyses. The studies were conducted at 111 centers...