... to have broader applications in cardiac surgery in the future. aortic stenosis therapy anterior right mini-thoracotomy direct aortic transcatheter aortic valve implantation minimally invasive cardiac surgery virtual reality case report ACCEPTED MANUSCRIPT 1 Two Cases of Direct Aortic Transcatheter...

... by cancer therapies, which are known to have cardiotoxic effects. Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially developed for treating diabetes, have shown promising cardiovascular benefits in non-cancer populations, particularly in preventing heart failure (HF) and reducing HF-related...

[email protected]. 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Poor adherence to lipid lowering therapy (LLT) is a major barrier in the prevention...

..., provided the original work is properly cited. Abstract Aims Therapeutic advancements have significantly enhanced cancer patient survival rates, yet concomitantly increased the prevalence of associated toxicities, such as cancer therapy-related cardiac dysfunction (CTRCD), either symptomatic (heart...

... excluded, and 12 did not complete neoadjuvant therapy due to comorbidities. This resulted in 136 patients receiving HER2-positive neoadjuvant treatment. These patients were then divided based on tumor-infiltrating lymphocyte (TIL) levels: 63 patients had TIL levels ≥10%, with a subset of 36 patients having...

... macrophage polarization. These findings highlight AAV2-IL-4 as a promising gene therapy strategy for bone regeneration, effectively integrating immunomodulation and osteogenesis to counteract inflammation-driven bone loss. Graphical Abstract Graphical Abstract Lay Summary Bone loss due to inflammation...

... treatment sites. halcyon patient setup error cone beam computed tomography patient positioning radiation therapy VMAT IMRT Precise patient positioning is fundamental to successful radiotherapy, ensuring therapeutic radiation doses are accurately directed to the tumor, while simultaneously minimizing...

... that offer new avenues for research, and then explore the applications of CRISPR technology in large-scale genetic screening, lineage tracing, genetic diagnosis, and gene therapy. As this technology evolves, it holds significant promise for studying gene functions and treating human diseases in the near...

... Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Objectives To explore efficacy and safety of CD19-directed Chimeric Antigen Receptor (CAR) T cell therapy in a patient with Jo1-Antisynthetase-syndrome (ASyS) refractory to multiple immunosuppressants, including...

... of the image-rotation technique and zooming augmentation to improve the accuracy of the deep learning (DL)-based dose conversion from pencil beam (PB) to Monte Carlo (MC) in proton beam therapy (PBT). We adapted 85 patients with head and neck cancers. The patient dataset was randomly divided into 101 plans...

... lifestyle intervention metformin therapy risk prediction precision medicine ACCEPTED MANUSCRIPT 1 Title: Development and validation of a diabetes risk prediction model with individualized 2 preventive intervention effects 3 4 Short title: Preventive diabetes risk prediction 5 6 Authors 7 Byron Jaeger...

... Cancer Center, Lyon, France ( [email protected] ) antiangiogenic therapy medulloblastoma MEMMAT metronomic chemotherapy pineoblastoma SHH Feasibility and efficacy of MEMMAT-like regimen in heavily pre-treated adult patients with recurrent malignant embryonal brain tumors: a series...

... has been reported in B-ALL at diagnosis and short-term follow-ups after standard chemotherapies. However, there are no data available in relapsed/refractory (r/r) patients who have received long-term and multiline therapies, especially chimeric antigen receptor (CAR) T cells; here, we focused...

... for >28 days; 25 [20/5] mg/kg/dose for ≤28 days) were similar to approved doses for older children. The safety profile of CAZ/AVI was as expected based on previous observations. Neonatal infection Gram-negative bacteria antibiotic therapy antimicrobial resistance sepsis Accepted Manuscript...

... inflammation consistent with TB. Managed with modified radical mastectomy, adjuvant chemotherapy, and antitubercular therapy, the patient showed complete disease resolution on follow-up. This rare coexistence underscores the necessity for histopathological confirmation and multidisciplinary management...

... [email protected]. 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) menopausal hormone therapy cardiovascular disease tibolone Korean cohort hormone...

... of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Why more males than females start kidney replacement therapy (KRT...

...&utm_source=ITP Hepatitis B resource-limited settings point-of-care viral load antiviral therapy Open Forum Infectious Diseases BRIEF REPORT Time to initiation of hepatitis B treatment is reduced with the use of the Xpert HBV viral load kit ACCEPTED MANUSCRIPT Hailemichael Desalegn1,2, Nega Berhe3,4...

.../by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Advanced combination therapy with biologics and small molecules has seen more widespread implementation for inflammatory bowel disease (IBD...

... liposome-based host-directed therapies. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. 17 12 2024 05 03...