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Neutral transcriptome rewiring promotes quantitative disease resistance evolvability at the species level
Florent Delplace and others
The Plant Cell, koaf105, https://doi.org/10.1093/plcell/koaf105
Published: 09 May 2025
... be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Quantitative disease resistance (QDR) is an immune response limiting pathogen damage in plants. It involves transcriptomic...
Journal Article
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The Pathogen Adaptation of HLA Alleles and the Correlation with Autoimmune Diseases in the Han Chinese
Shuai Liu and others
Genomics, Proteomics & Bioinformatics, qzaf038, https://doi.org/10.1093/gpbjnl/qzaf038
Published: 29 April 2025
...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Human leukocyte antigen (HLA) genes play a crucial role in the adaptation of human populations to the dynamic pathogenic environment. Despite...
Journal Article
Genome-wide Evidence of Host Specialization in Wild and Farmland Populations of the Fungal Leaf Spot Pathogen, Cercospora beticola
Demetris Taliadoros and others
Genome Biology and Evolution, Volume 17, Issue 4, April 2025, evaf053, https://doi.org/10.1093/gbe/evaf053
Published: 28 April 2025
... of novel pathogens, which may spread across large geographical distances with their crop host. In this study, we addressed the recent evolution of the fungal pathogen causing the disease Cercospora leaf spot, Cercospora beticola. This pathogen has become increasingly important in sugar...
Journal Article
An overview of host immune responses against Leishmania spp. infections
Hanna Paton and others
Human Molecular Genetics, ddaf043, https://doi.org/10.1093/hmg/ddaf043
Published: 27 April 2025
... shock, their involvement in innate immune responses is equally significant, as evidenced by their critical role in producing inflammatory cytokines [ 47 ]. The role of mast cells during Leishmania spp. infections has been contentious, and whether these cells play a protective or pathogenic role...
Journal Article
Mapping genomic regions associated with temperature stress in the wheat pathogen Zymoseptoria tritici
Jessica Stapley and others
G3 Genes|Genomes|Genetics, jkaf094, https://doi.org/10.1093/g3journal/jkaf094
Published: 26 April 2025
... ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Climate change can alter interactions between plants and their pathogens, which could adversely affect crop production...
Journal Article
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Evolutionary and functional analysis of caspase-8 and ASC interactions to drive lytic cell death, PANoptosis
Sivakumar Prasanth Kumar and others
Molecular Biology and Evolution, msaf096, https://doi.org/10.1093/molbev/msaf096
Published: 25 April 2025
...-pathogen interactions Caspases ASC PYCARD DED filament Helical assembly cell death Apoptosis Necroptosis Pyroptosis PANoptosis Inflammasome PANoptosome Evolution Arms race Co-evolution Crosstalk Death fold Death domain superfamily Inflammation Inflammatory response Innate immunity...
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Treatment of antibiotic-manufacturing wastewater enriches for Aeromonas veronii, a zoonotic antibiotic-resistant emerging pathogen
Xingshuo Wang and others
The ISME Journal, wraf077, https://doi.org/10.1093/ismejo/wraf077
Published: 21 April 2025
..., but their processes may select for antibiotic-resistant pathogens and antibiotic resistance genes. Here, leveraging the combined strengths of deep metagenomic sequencing, 16S rRNA gene sequencing, qPCR, and bacterial culturing, we investigated bacterial communities and antibiotic resistomes across eleven treatment...
Journal Article
Phosphatidylinositol 5-Phosphate-Loaded Apoptotic Body-Like Liposomes for Mycobacterium abscessus Infection Management in Patients With Cystic Fibrosis
Tommaso Olimpieri and others
The Journal of Infectious Diseases, jiaf124, https://doi.org/10.1093/infdis/jiaf124
Published: 18 April 2025
...-directed therapy against M. abscessus infection, especially in people with CF who cannot access ETI treatment. Mycobacterium abscessus cystic fibrosis liposomes ETI host-directed therapy pathogen-directed therapy innate immunity phosphatidylinositol 5-phosphate Italian Cystic...
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Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis
Emily J Stevens and others
The ISME Journal, Volume 19, Issue 1, January 2025, wraf071, https://doi.org/10.1093/ismejo/wraf071
Published: 17 April 2025
... Pathogens newly invading a host must compete with resident microbiota. This within-host microbial warfare could lead to more severe disease outcomes or constrain the evolution of virulence. By passaging a widespread pathogen (Staphylococcus aureus) and a natural microbiota community across...
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Silenced cutters: mechanisms and effects of protease inhibition in plant-pathogen interactions
Catarina Paiva-Silva and others
Journal of Experimental Botany, eraf156, https://doi.org/10.1093/jxb/eraf156
Published: 12 April 2025
... in any medium, provided the original work is properly cited. Abstract Proteases are essential enzymes in plants that play multiple roles in immunity, including molecular recognition, programmed cell death, and the degradation of pathogen proteins. During plant-pathogen interactions, both organisms have...
Journal Article
Preventative medicine? Examining prophylactic effects of a sunflower pollen diet in Bombus impatiens ([Hymenoptera]: [Apidae])
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Cameron C Lamphere and others
Journal of Economic Entomology, toaf051, https://doi.org/10.1093/jee/toaf051
Published: 03 April 2025
.../standard-publication-reuse-rights ) Abstract Widespread decline of pollinator populations is of concern for both natural and agricultural ecosystems. Pathogens have been identified as a major contributor to the decline of some bee species, making understanding host–pathogen dynamics a crucial area...
Journal Article
Reference-Free Variant Calling with Local Graph Construction with ska lo (SKA)
Romain Derelle and others
Molecular Biology and Evolution, Volume 42, Issue 4, April 2025, msaf077, https://doi.org/10.1093/molbev/msaf077
Published: 02 April 2025
... of pathogens. Traditional variant-calling methods from whole-genome sequencing data rely on reference-based alignment, which can introduce biases and require significant computational resources. Alignment- and reference-free approaches offer an alternative by leveraging k-mer-based methods...
Journal Article
Methods of active surveillance for hard ticks and associated tick-borne pathogens of public health importance in the contiguous United States: a comprehensive systematic review
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Sulagna Chakraborty and others
Journal of Medical Entomology, tjaf031, https://doi.org/10.1093/jme/tjaf031
Published: 20 March 2025
.../pages/standard-publication-reuse-rights ) Abstract Tick-borne diseases in humans and animals have increased prevalence across the United States. To understand risk factors underlying tick-borne diseases it is useful to conduct regular surveillance and monitoring of ticks and the pathogens they carry...
Journal Article
Differential physiological responses of resistant and susceptible grape cultivars to Eutypa dieback
Gabriela C Sinclair and others
Journal of Experimental Botany, eraf103, https://doi.org/10.1093/jxb/eraf103
Published: 18 March 2025
... in any medium, provided the original work is properly cited. Abstract Eutypa lata is a fungal pathogen of grapevine that causes widespread economic damage and threatens vineyard longevity worldwide. This study was initiated to further understanding of how grapevines resist E. lata...
Journal Article
Bacillus subtilis ensures high spore quality in competition with Salmonella Typhimurium via the SigB-dependent pathway
Eli Podnar and others
The ISME Journal, Volume 19, Issue 1, January 2025, wraf052, https://doi.org/10.1093/ismejo/wraf052
Published: 18 March 2025
... Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The interactions between beneficial bacteria and pathogens are understudied. Here we...
Journal Article
Influence of pH and oxygen levels on the antimicrobial efficacy of acetic acid against Salmonella Typhimurium
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Fernando K C Da Costa and others
Journal of Applied Microbiology, Volume 136, Issue 3, March 2025, lxaf059, https://doi.org/10.1093/jambio/lxaf059
Published: 17 March 2025
... under the proposed adverse conditions for further prediction of the bacterial behavior and AA inhibition efficacy. The most common reservoir of Salmonella is the host’s gastrointestinal tract (GIT) (Álvarez-Ordóñez et al. 2012 ), where these pathogens can survive under adverse environmental...
Journal Article
Human activity, not environmental factors, drives Scedosporium and Lomentospora distribution in Taiwan
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Hsin-Mao Wu and others
Medical Mycology, Volume 63, Issue 3, March 2025, myaf022, https://doi.org/10.1093/mmy/myaf022
Published: 06 March 2025
... pathogens capable of causing severe infections in both immunocompetent and immunocompromised individuals. Previous environmental surveys have suggested potential associations between these fungi and various soil chemical parameters, though the relative influence of human activity versus environmental...
Journal Article
Season-long microbial dynamics from the cuticle of rice weevil originating at food facilities after dispersal to novel food patches
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William R Morrison and others
Environmental Entomology, Volume 54, Issue 2, April 2025, Pages 296–308, https://doi.org/10.1093/ee/nvaf012
Published: 21 February 2025
... understanding of insect–microbe interactions after harvest and highlights variable periods of risk by food facilities over the season. Graphical Abstract Graphical Abstract vectoring plant pathogen stored product Sitophilus oryzae behavioral ecology dispersal NIFA Crop Protection and Pest...
Journal Article
Percutaneous thrombectomy assisted lead extraction: successful diagnosis and treatment in a case report of culture negative endocarditis
Sujoy Khasnavis and others
European Heart Journal - Case Reports, Volume 9, Issue 3, March 2025, ytaf086, https://doi.org/10.1093/ehjcr/ytaf086
Published: 18 February 2025
... and accurate in catching P. acnes and other rare endocarditis pathogens when conventional tests are inconclusive. The system is also therapeutically useful as it debulks ICD vegetations and facilitates both LE and antibiotic treatment with low risk for complications. Dr Sujoy Khasnavis is a PGY-3...
Journal Article
An investigation of Haemaphysalis longicornis (Ixodida:Ixodidae) habitat and pathogen overlap with resident tick species in Southeastern Pennsylvania forests
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Payton M Phillips and others
Journal of Medical Entomology, Volume 62, Issue 2, March 2025, Pages 465–470, https://doi.org/10.1093/jme/tjae159
Published: 11 February 2025
.... longicornis transmits numerous disease-causing pathogens in its native range, it is unclear to what extent H. longicornis will act as a disease vector in the United States. The ability of H. longicornis to acquire pathogens likely depends on overlap with resident tick species in both habitat...
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