... was operationalized as NPS persistence at >2/3 of pre-dementia study visits; otherwise, status was non-MBI NPS. The presence of AD, Lewy body disease (LBD), and TDP-43 neuropathological changes were determined using published guidelines. Adjusted multinomial logistic regressions modeled pathology-NPS status...

... of neuropathological severity than traditional staging systems, but its reliability remains underexplored. We calculated regional percentage areas occupied by phosphorylated tau (p-Tau, AT8), amyloid-β (Aβ, NAB228), and phosphorylated α-synuclein (p-αSyn, 81A) pathology in 24 autopsied cases with varying degrees...

...-cell response in PSP than in PD supports the notion that the common p-tau neuropathology in PSP might have potential relationships with autoimmune mechanisms. Inflammation has been suggested to play a role in neurodegenerative disease. Couto et al. found increased numbers of cytotoxic T cells...

... neuropathology handedness ACCEPTED MANUSCRIPT 1 REVIEW ARTICLE 2 Asymmetry in amyotrophic lateral sclerosis: clinical, 3 neuroimaging and histological observations 4 Katie Yoganathan,1,2 Thanuja Dharmadasa,1,2 Alicia Northall,1,2 Kevin Talbot,1 Alexander G. 5 Thompson1 and Martin R. Turner1,2 6 Abstract 7...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Studies assessing genetic associations with neuropathological features in Lewy body disease (LBD) have been limited to candidate gene investigations, and therefore information is lacking regarding the genetic architecture of the neuropathology...

... to investigate the prevalence and associations of neuropathologic changes and comorbidities, and their correlation with genetics and cognition in a community-dwelling autopsy cohort in China. Datasets of 610 participants were obtained from the National Human Brain Bank for Development and Function...

.... Gilbert Family Foundation 10.13039/100016618 Morgan Adams Foundation 10.13039/100012869 Ross Family UCSF Department of Pathology Experimental Neuropathology Endowment Fund UCSF Program for Breakthrough Biomedical Research UCSF Brain Tumor SPORE P50 CA097257 Key...

... tumors that were deemed diagnostically uncertain after 2 rounds of review by neuropathology experts. In this study, DNA methylation was considered contributory to a final diagnosis in 71% of these cases. ⁵⁰ A population-based study in the United Kingdom assessed the impact of DNA methylation...

... methylation assay neuropathology LMIC Abstract Background The 2021 World Health Organization classification of Central Nervous System tumors (CNS5) includes molecular biomarkers in the necessary diagnostic criteria for many tumors. Identifying these markers often requires next-generation sequencing (NGS...

... 17 05 2024 25 09 2024 26 10 2024 25 03 2025 deep learning Alzheimer’s disease vascular dementia Lewy body dementia MRI neuropathology National Institute of Health 10.13039/100000002 NIH 10.13039/501100012264 P30AG066546 South Texas Alzheimer’s Disease Research...

...Klara Gawor; Sandra O Tomé; Rik Vandenberghe; Philip Van Damme; Mathieu Vandenbulcke; Markus Otto; Christine A F von Arnim; Estifanos Ghebremedhin; Alicja Ronisz; Simona Ospitalieri; Matthew Blaschko; Dietmar Rudolf Thal Correspondence to: Dietmar R. Thal Laboratory of Neuropathology, Department...

... the original work is properly cited. Graphical Abstract Graphical Abstract neuropathology neurodegeneration Alzheimer’s disease dementia National Institutes of Health 10.13039/100000002 National Institute on Aging 10.13039/100000049 R01 AG062695 NIA 10.13039/501100023864 NIH...

... glioblastoma gliosarcoma molecular neuropathology temozolomide-induced hypermutation Longitudinal molecular profiling studies have revealed that glioblastoma displays a high degree of clonal stability during therapy, although private mutations between primary and recurrent tumor samples are common. ³...

... continue to evolve in concert with our understanding of these neoplasms. consensus guidelines molecular neuropathology nerve sheath tumor neurofibromatosis type 1 National Institutes of Health 10.13039/100000002 National Cancer Institute 10.13039/100000054 Peripheral nerve sheath tumors...

... Microscopic evaluation 55.9 76.5 67.5 Evaluation summary 64.6 71.9 86.4 C and P denote information extracted by Curation and Pipeline, respectively. C∩P denotes records intersection of sets of records, C∪P denotes union of sets. Table 3. Number of reports with neuropathological diagnosis...

... neuropathology and extends the lifespan of SCA3 animal models. ¹³ However, the use of viral vector-mediated intracranial injection entails invasive surgical procedures and safety concerns, and long-term repeated administration might induce neuroinflammation. ^{13 , 14} Furthermore...

... Escherichia coli, including cell wall lipopolysaccharide and fimbrial antigen proteins, were associated with Ad neuropathology [ 18 ]. Fimbrial proteins are recognized as virulence factors for several pathogenic bacteria, including E coli, and are essential for attachment...

... Sahm, MD, PhD, Department of Neuropathology Heidelberg, University Hospital Heidelberg, 69120 Heidelberg, Germany ( [email protected] ) Corresponding Author: Arie Perry, MD, Department of Pathology, Division of Neuropathology, University of California, San Francisco, San Francisco, CA...

...; n (%) 4 (33) 2 (22) Table 7 Neuropathological features of participants with first-ever non-lobar ICH without prior cognitive impairment versus with cognitive impairment (but not dementia) versus with prior dementia No cognitive impairment (n = 36) Cognitive impairment...

... between variable BP and cognitive/brain changes. This study examined the relationship between variable BP and longitudinal cognitive, white matter hyperintensity (WMH), gray matter (GM), and white matter (WM) volume change over time and postmortem neuropathology. Methods A total of 4,606 participants...