..., and management strategies for unique meningioma patient populations. In each section, we discuss the current state of knowledge as well as ongoing clinical and research challenges to road map future directions for further investigation. extra-axial meningioma methylation molecular neurofibromatosis 2...

... neuroma vestibular schwannoma mosaicism neurofibromatosis 2 schwannomatosis KEY POINTS This is the first case report in the English-language literature of a patient presenting with 4 distinct ipsilateral schwannomas and negative germline testing, suggestive of mosaic schwannomatosis...

... neurofibromatosis 2 vestibular schwannoma National Center for Advancing Translational Sciences 10.13039/100006108 UL1 TR002377 NIH 10.13039/100000002 Key Points Bevacizumab slows vestibular schwannomas (VS) growth with a trend toward hearing preservation. Most patients discontinue bevacizumab due...

...Justin T Jordan; Christina C Orr; Raquel D Thalheimer; Josephine V Cambillo; Roberta L Beauchamp; Ghalib Shaikh; Alona Muzikansky; Anat Stemmer-Rachamimov; Marco Giovannini; Michel Kalamarides; Fred G Barker; Vijaya Ramesh; Scott R Plotkin meningioma mTOR mTORC1 mTORC2 neurofibromatosis 2 NF2...

... Maintenance bevacizumab (5 mg/kg every 3 weeks) is associated with high rates of hearing and tumor stability during 18 months of follow-up. No new unexpected adverse events related to bevacizumab were identified in this population. bevacizumab maintenance neurofibromatosis 2 NF2 vestibular schwannoma...

... and radiosurgery, including new data on the latter will be reviewed. Finally, I will discuss how loss of merlin leads to tumourigenesis in order to understand the rationale for emerging new therapeutic targets. schwannoma meningioma ependymoma neurofibromatosis 2 merlin Mutations in the NF2 gene...

..., Sujansky E, Rubenstein A. Neurofibromatosis. 2, radiosurgery and malignant nervous system tumours. Br J Cancer . 2000 ; 82 : 998 . 30 Plowman PN, Evans DG. Stereotactic radiosurgery XI. Acoustic neuroma therapy and radiation oncogenesis. Br J Neurosurg . 2000 ; 14 : 93 -95. 31 Bhattacharyya...

... by NIH grants NS24279 and CA51410. © 1998 by the American Association of Neuropathologists 1998 Abstract Loss of the neurofibromatosis 2 (NF2) gene-encoded protein merlin is a universal finding in sporadic and NF2-associated schwannomas. Certain NF2 patients may develop numerous minute Schwann...

.... Supported by NIH grant NS24279 and by a grant from the U.S. Army. CG-A is supported by a Young Investigator Award from the NNFF. © 1997 by the American Association of Neuropathologists, Inc. 1997 Abstract Germline mutations of the neurofibromatosis 2 (NF2) gene are associated with an increased...

...Anat O. Stemmer-Rachamimov; Michael A. Horgan; Ana Lia Taratuto; David G. Munoz; Thomas W. Smith; Matthew P. Frosch; David N. Louis Meningioangiomatosis Neurofibromatosis 2 NF2 gene Abstract Meningioangiomatosis occurs sporadically and in patients with neurofibromatosis. The literature, however...

... in tumorigenesis of these tumors. Ependymoma Meningioma Merlin Neurofibromin Neurofibromatosis 2 Schwannoma Schwannomin ...

... of <20 years but each had <2 spinal tumors. TABLE 1. Clinical Characteristics of Patients with Neurofibromatosis 2 by Phenotype^a Bilateral VSs were found in 43 patients (90%), and unilateral VSs were found in 3 (6%). Eight patients (17%) had unilateral trigeminal schwannomas...

... of Finland, the Finnish Cancer Foundation, the Maire Taponen Foundation, and the Medical Research Fund of Pirkanmaa. © 1995 by the American Association of Neuropathologists 1995 Abstract Neurofibromatosis 2 (NF2), a dominantly inherited disorder, is typically manifested as bilateral vestibular Schwannomas...

... Analysis of the Neurofibromatosis 2 Gene in Human Breast and Hepatocellular Carcinomas Yae Kanai, Hitoshi Tsuda, Tatsuya Oda, Michiie Sakamoto and Setsuo Hirohashi Pathology Division, National Cancer Center Research Institute, Tokyo The neurofibromatosis 2 gene (NF2) mapped...

...Tsutomu Hitotsumatsu; Tetsuyuki Kitamoto; Toru Iwaki; Masashi Fukui; Jun Tateishi ¹To whom correspondence should be addressed. 25 8 1994 © BY THE JOURNAL OF BIOCHEMISTRY 1994 Abstract We succeeded in cloning the exon 8-spliced out transcript of neurofibromatosis 2 (NF2) gene...

..., Helsinki University Central Hospital, Topeliuksenkatu 5, FIN-00260, Helsinki, Finland. 14 01 1994 31 03 1994 Abstract THE AUTHORS COMPARED the long-term recovery of sutured facial nerves after the removal of 8 neurofibromatosis-2 (NF2)-associated and 22 non-NF2 acoustic neuromas. The patients were...

...Victor-F. Mautner; Marcos Tatagiba; Rolf Guthoff; Madjid Samii; Stefan-M. Pulst * Reprint requests: Stefan-M. Pulst, M.D., Cedars-Sinai Medical Center, B216, 8700 Beverly Blvd., Los Angeles, CA 90048. 11 11 1992 10 02 1993 Neurofibromatosis 2 (NF2) is an autosomal dominant disease...

.... neurofibromatosis 2 neurofibromatosis 2 central neurofibromatosis bilateral acoustic neurofibromatosis bilateral vestibular schwannomas meningiomas EGFR/ErbB2 mTOR Acoustic neuroma Bilateral vestibular schwannomas Cutaneous schwannomas neurofibromatosis type 2 Epilepsy syndromes childhood Familial...

.... neurofibromatosis 1 neurofibromatosis 2 schwannomatosis optic pathway glioma neurofibroma schwannoma bony lesions in neurofibromatosis type 1 café au lait macules in neurofibromatosis type 1 cardiofaciocutaneous syndrome congenital mismatch repair syndromes ependymoma fibromatoses freckling...