... (NPCs), NUP85, NUP107, NUP133 and NUP160, cause monogenic steroid-resistant nephrotic syndrome (SRNS). Knockout of NUP85, NUP107, or NUP133 in immortalized human podocytes activates CDC42, an important effector of SRNS pathogenesis. However...

... of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Membranous nephropathy (MN) is a leading cause of nephrotic syndrome...

... Abstract Background and hypothesis Adult and pediatric patients with nephrotic syndrome (NS) due to different glomerular diseases are at a higher risk of thromboembolic events than the general population, but the use of prophylactic anticoagulation (PAC) among them has not been well described. Although...

... autoantibodies targeting the podocyte protein nephrin in patients with primary podocytopathies such as minimal change disease (MCD), primary focal segmental glomerulosclerosis (pFSGS), post-transplant recurrent FSGS (rFSGS) and childhood idiopathic nephrotic syndrome (INS). These antibodies bind nephrin...

... nephrotic syndrome obinutuzumab rituximab National Natural Science Foundation of China 10.13039/501100001809 82070705 81770670 81970640 82370735 Clinical Research Project of Shanghai Municipal Health Commission 20234Y0175 Oriental Talent Plan Outstanding Program 2023, the Shanghai...

... poor outcomes despite advances in immunosuppressive therapies. Low-density lipoprotein apheresis (LDL-A) has been a potential therapeutic option for steroid-resistant nephrotic syndromes (NSs), but its efficacy in LN remains unknown. Here, we report the case of a 26-year-old female patient with SLE...

... mercury-containing creams to nephrotic syndrome. Minimal change disease and membranous nephropathy are the most frequently reported glomerular diseases due to these products. Treatment typically involves stopping the use of the creams and chelation therapy, with glucocorticoids and immunosuppressants...

...-publication-reuse-rights ) Dapagliflozin Nephrotic Syndrome Abstract Background The nephrotic syndrome has one of the best-known presentations of adult and pediatric kidney disease. The incidence of nephrotic syndrome is approximately 2 to 4 new cases per 100,000 population per year. While advances had...

... hypertensive nephrosclerosis was the most common in the age groups of 40-59 (27%) and ≥60 (25.6%). Conclusion Renal biopsy most commonly presents with nephrotic syndrome. Primary glomerulonephritis is the most common diagnosis, with membranous GN being the most prevalent. Lupus nephritis is the most common...

... Background Idiopathic nephrotic syndrome (INS) in children, commonly treated with steroids, poses challenges due to associated side effects. Rituximab, known for its efficacy in reducing relapse frequency in difficult-to-treat cases, emerges a potential first-line therapy for pediatric new-onset INS...

... There are limited data on the long-term outcomes and risk factors for non-recovery after development of rituximab (RTX)-associated persistent hypogammaglobulinaemia among children with idiopathic nephrotic syndrome (NS). Methods A nationwide Japanese survey was conducted to determine the prognosis of patients...

...Jinxia Chen; Ruting Li; Hua Guo; Tianyu Zhu; Yongzhi Xu; Cuiwei Yao; Huafeng Liu Minimal change nephrotic syndrome (MCNS) is a common aetiology of glomerular diseases and leads to 10–25% of nephrotic syndrome in adults [ 1 , 2 ]. It is present with intense proteinuria accompanied by oedema...

...Anna Matyjek; Stanisław Niemczyk; Sławomir Literacki; Wojciech Fendler; Tomasz Rozmysłowicz; Andreas Kronbichler KEY LEARNING POINTS What was known: Patients with nephrotic syndrome (NS) have a substantial loss of thyroid hormones and carrier proteins during episodes of active nephrosis...

... Background Idiopathic nephrotic syndrome (NS) in children poses treatment challenges, with a subset developing steroid-resistant nephrotic syndrome (SRNS). Genetic factors play a role, yet data on paediatric SRNS genetics in India are scarce. We conducted a prospective study using whole-exome sequencing...

... nephrotic syndrome pyroptosis JSPS 10.13039/501100000646 21K16171 KEY LEARNING POINTS What was known: Adult-onset minimal change disease (MCD) frequently reoccurs and requires prolonged immunosuppressive therapy compared with childhood MCD; thus, an investigation of the pathogenesis of adult MCD...

... treatments; Group B, children with INS under low-dose maintenance corticosteroid treatment; Group C, control group, INS, idiopathic nephrotic syndrome; CsA, cyclosporine A; c2, concentration of CsA in serum 2 h after CsA administration; MMF, mycophenololate mofetil. © The Author(s) 2024. Published by Oxford...

.... There is a need to investigate different induction therapy regimens for the remission of MCD patients with different backgrounds. glucocorticoid minimal change disease nephrotic syndrome remission rituximab Shandong Natural Science Foundation 10.13039/501100007129 ZR2022MH322 Science and Technology...

... and regeneration, including congenital nephrotic syndrome, may allow clinicians to more closely monitor for and anticipate changes in patients' renal function. When an infant presents with hypercalcemia, initial testing should include evaluation of PTH, inactive and active forms of vitamin D, urine studies...

.../licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background Idiopathic nephrotic syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies...

... than PCR as a predictor of renal prognosis in patients with Japanese pMN. Graphical Abstract Graphical Abstract clearance fractional excretion of total protein nephrotic syndrome primary membranous nephropathy renal prognosis Primary membranous nephropathy (pMN) is one of the most common types...