...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Several ongoing clinical trials are evaluating high-dose rifampicin (up to 35 mg/kg) for tuberculous meningitis (TBM). However...

... Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract The promising results of the Ambition-CM trial in persons with HIV have sparked interest in treating non-HIV-associated cryptococcal meningitis with single 10mg/kg liposomal amphotericin B, combined...

... other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract We analyzed the impact of a diagnostic meningitis/encephalitis polymerase chain reaction panel...

... information please contact [email protected]. Abstract Tuberculous meningitis remains the most lethal form of tuberculosis. Despite significant physiological differences adults and children with tuberculous meningitis receive similar treatment and are often grouped together in research...

..., provided the original work is properly cited. Abstract Background Differentiating cryptococcal meningitis from tuberculous meningitis is critical for initiating appropriate treatment and improving patient outcomes. However, overlapping pathogenic mechanisms, clinical presentations, laboratory findings...

...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Host immune responses to HIV-associated cryptococcal meningitis are critical in disease outcome. Their interaction...

... on health system resilience in responding to the cerebrospinal meningitis (CSM) outbreak in Ghana. Methods A qualitative study design and purposive sampling were used to select clinical, public health staff and community health volunteers. From October 2023 to January 2024, data were collected across...

... Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Meningitis after resection of a cerebral alveolar hydatid cyst (CAHC) is rare. Although...

... Background Tuberculous meningitis (TBM)–related deaths occur early, often within weeks after treatment initiation. Enhanced treatment early in the disease course with agents that effectively penetrate the central nervous system may improve outcomes in TBM. Methods We conducted a phase 2, open-label...

... both in acuity and severity. ⁵ CNS infections can be classified based on structures involved, including meningitis (meninges), encephalitis (brain parenchyma), and myelitis (spinal cord), and combinations including meningoencephalitis and encephalomyelitis when multiple compartments...

...-reuse-rights ) Abstract Background Nervous system infections are associated with long-term risks of neurological disorders and healthcare service utilization, but little data exist on the long-term risks of enteroviral meningitis in childhood. Methods We performed a population-based, nationwide...

...-reuse-rights ) Abstract In this population-based, nationwide Danish cohort study, bacterial meningitis in childhood was associated with increased neurological morbidity. The risks were highest among young children, who also received more antiepileptic medication. All children had increased frequency...

...; Streptococcus agalactiae) is a gram-positive colonizer of the healthy intestinal and genitourinary microbiota. During and shortly after birth, neonates and infants can be opportunistically infected leading to sepsis, pneumonia, or meningitis among other illnesses. GBS is the leading cause of neonatal...

... page on our site—for further information please contact [email protected]. Abstract Background Neurocognitive impairment in HIV-associated cryptococcal meningitis survivors remains poorly characterized. We sought to identify risk factors associated with sustained neurocognitive impairment...

... taking ART, with a median duration of 9 months (269 days, IQR 25–1952 days); 72/398 (18%) had initiated ART ≤14 days before presentation with cryptococcal meningitis, 77/398 (19%) had been on ART between >14 days and 2 months, 42/398 (11%) between >2 months and 6 months, and 207/398 (52%) had been...

... results with an 44.4% decrease in assay median turnaround time (from 9 to 4 days). Prioritizing strategies to reduce assay turnaround time would likely improve patient care management and enhance the clinical impact of CSF mNGS testing. mNGS neurologic infections meningitis encephalitis...

... ) Abstract Given extensive improvements in access to antiretroviral therapy (ART) over the past 12 years, the HIV and cryptococcal meningitis landscapes have dramatically changed since 2010. We sought to evaluate changes in clinical presentation and clinical outcomes of people presenting with HIV-associated...

...-reuse-rights ) Abstract In young children, pneumococcal meningitis epitomizes the paradigm of a destructive innate inflammatory response in the central nervous system: a five-alarm fire. In contrast, cell-free bacterial components reaching the fetal brain from an infected mother signal a quiet...

... from mild illness to neurologic manifestations of meningitis, encephalitis, and acute flaccid myelitis. Disease manifestations are driven by a combination of viral replication and host immune response. Despite ubiquitousness and clinical importance, there are no approved targeted therapies...

... characteristic of the 1904-1907 meningitis outbreaks, a reflection of the burgeoning status played by the media in communicating information about disease globally. Since the nineteenth century, journalists conveyed information about outbreaks and, in so doing, helped construct society’s emotional responses...