... in the development of improved strategies for inflammatory pain management. Graphical Abstract Graphical Abstract Enhancement of the analgesic effects of low-dose DFC by Pav in AIA mice, as evidenced by suppressed spinal excitatory neuronal activity. Pavlova Arthritis Diclofenac Inflammatory pain...

... and neuropathic pain. Targeting spinal mTORC2 could represent a novel strategy for reducing nocioceptive plasticity and chronic pain. See He et al. ( https://doi.org/10.1093/brain/awaf004 ) for a scientific commentary on this article. mTORC2 Rictor spinal cord neuropathic pain inflammatory pain AKT...

...Niels Jansen; Peter M ten Klooster; Harald E Vonkeman; Boudewijn van den Berg; Jan R Buitenweg rheumatoid arthritis non-inflammatory pain quantitative sensory testing DAS28 inflammation After all patients had been included and measured, their DAS28-ESR measurements (tender joints, swollen...

...-term pain despite low inflammation in early RA. rheumatoid arthritis pain patient reported outcomes prediction non-inflammatory pain tender-swollen difference The Swedish Research Council 2015–02228 The Swedish Rheumatism Association R-664091 Lund University 10.13039/501100003252...

...Shakil Khan; Pabitra Hriday Patra; Hannah Somerfield; Hattaya Benya-Aphikul; Manoj Upadhya; Xuming Zhang To induce inflammatory pain, 20 μl of Complete Freund’s Adjuvant (CFA, Merck) was injected into the hind paws of mice. For neuropathic pain, we performed spared nerve injury (SNI) on mice...

... treatment in rodents had an analgesic effect, which was more effective in inflammatory pain than in neuropathic pain in the early phase of treatment. The analgesic efficacy became more curative after repeated acupuncture. Furthermore, acupuncture treatment could effectively inhibit the activity...

... Laboratories; surgery was performed at Charles River Laboratories on postnatal Day 21. After animals recovered from surgery, they were shipped to the University of Ottawa Heart Institute and left to mature to age-match the intact animals. To model persistent inflammatory pain, complete Freund’s adjuvant (CFA...

... of 2-BP on inflammatory pain  2-BP attenuates inflammatory pain via regulating mitochondrial fission/fusion balance and function in the spinal cord. Abstract Inflammatory pain activates astrocytes and increases inflammatory cytokine release in the spinal cord. Mitochondrial fusion and fission rely...

... sodium (Nav) channels are important determinants of the excitability of sensory neurons. Hence we tested the hypothesis that CCL2 contributes to inflammatory pain via modulating Nav channel activity of primary afferent neurons. Chronic inflammatory pain was induced in rats by intraplantar injection...

... growth factor 7 dorsal root ganglion large dense-core vesicle nociceptive modulator inflammatory pain Fibroblast growth factor (FGF) 7 is a member of FGF family, and its high affinity receptor is FGFR2b ( Rubin et al., 1989 ; Miki et al., 1992 ). Previous studies suggest that FGF7 plays a role...

...Lilian Basso; Jérôme Boué; Arnaud Bourreille; Gilles Dietrich Figure 2. Mucosal T-cell density modulates the intensity of visceral inflammatory pain. Colitis is induced by adding 3% DSS (weight/volume) into the drinking water for 5 days (D5). Then, from day 5 until day 10, animals receive only...

...Wan-Ru Duan; Jie Lu; Yi-Kuan Xie Topical analgesics have been widely applied to relieve pain since ancient times in China and worldwide. Chinese traditional medicine such as plasters (“Gao-Yao”) are a popular treatment for patients suffering from inflammatory pain in the deep tissue, including...

... and may have a therapeutic potential for treatment of inflammatory pain. activin C inflammatory pain dorsal root ganglion extracellular signal-regulated kinase Small-diameter neurons in the dorsal root ganglion (DRG) convey the peripheral nociceptive signals to their afferent terminals in the spinal...

... in animal studies and its implication in preclinical screening of potential analgesics. Allodynia Hyperalgesia Pain Assessment Inflammatory Pain Animal models of persistent pain provide useful analogs for the study of clinical pain conditions. The study of precise and replicable injuries produced under...

... Figure 1 ). Figure 1 Protocol used in carrageenan-induced inflammatory pain. Reprint requests to: Anton Kolosov, BSci, Monash Institute of Medical Research, Centre for Pain Medicine & Palliative Care, 27-31 Wright Street, Clayton, Vic. 3168, Australia. Tel: +61 3 9594 7762; Fax: +61 3...

... in the management of many painful conditions, the effectiveness and the mechanism of action of IFT in animal models of inflammatory pain have not been evaluated. The aim of this study was to evaluate the effectiveness of IFT in reducing inflammatory pain and edema in rats. Subjects. Sixty-nine male Wistar rats were...

...Oxford University Press This paper was one of several that cemented the key role of nerve growth factor (NGF) in sensory neurons in inflammatory pain processing. It used a novel way of biologically ‘removing’ NGF using a sequestration molecule that could then investigate the effect of the absence...

... together could be ideal for restoring the disordered metabolism underlying some pain syndromes. arthritis calorie restriction diabetes fasting fibromyalgia glucose inflammatory pain ketone body metabolic therapy neuropathic pain fasting inflammation neuropathic pain pain calorie restriction...

... analgesia, and revealed important insights into how the peripheral endocannabinoid system works in controlling both inflammatory pain and neuropathic pain. cannabinoid CB1 receptor central nervous system CNS peripheral nervous system pain modulation inflammatory pain neuropathic pain Amya F Argarwal...

... , Decosterd I , et al. Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity.   Proc Natl Acad Sci USA . 1999 ;96(16):9385–9390. 10.1073/pnas.96.16.9385 10430952 78.   Raghavendra V , Tanga FY , DeLeo JA...