... the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Glioblastoma (GB), particularly IDH-wildtype...

... Background Vortioxetine is a serotonin reuptake inhibitor and serotonin receptor modulator used for the treatment of major depressive disorder, but recent studies have also reported anticancer effects in models of glioblastoma. Given the well-established benefits of drug repositioning, we examined...

...—for further information please contact [email protected]. Abstract Background The optimal salvage therapy for recurrent MGMT-methylated glioblastoma (GBM), IDH wildtype, remains undefined. While lomustine is often used in clinical trials and considered standard-of-care, cumulative toxicity...

... for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background Glioblastoma (GBM) is an aggressive...

... [email protected]. ABSTRACT Background Immunotherapy has revolutionized cancer treatment but has yet to be translated into brain tumors. Studies in other solid tumors suggest a central role of B-cell immunity in driving immune checkpoint blockade efficacy. In glioblastoma (GBM), tumor B-cells are driven...

... on the tumor immune microenvironment are poorly understood. Methods Here, we developed senescent glioblastoma cell models in vitro via drug treatment. The protumor function of senescent cells was demonstrated by coinjection of chemotherapy-induced senescent cells with tumorigenic GL261 cells...

...Donghyun Hong; Noriaki Minami; Sabrina M Ronen Abstract Background Telomerase reverse transcriptase (TERT) promoter mutations are observed in most glioblastoma (GBM) tumors, leading to TERT expression, which is crucial for tumor growth. Accordingly, inhibiting TERT or its upstream tumor-specific...

.... Of the adult grade 2-4 gliomas, 12.15% (39/321), 8.76% (93/1062), and 6.88% (60/872) had PDGFRA gain/amplification in the SYSUCC, TCGA, and cBioPortal cohorts, respectively. Grade 4 glioblastomas had a greater PDGFRA gain/amplification rate than lower-grade gliomas (LGGs) in all cohorts (all...

... of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Glioblastomas are functionally integrated into their peritumoral neural...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Glioblastoma (GBM) is the most aggressive and lethal adult brain tumor. The cellular heterogeneity within the tumor microenvironment (TME) plays a critical role in the complexity of treatment and poor survival. GBM is typically classified into 3...

... RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background Therapeutic resistance in glioblastoma (GBM) is multifactorial and results from genetic heterogeneity, the immunoprivileged localization...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background The c-MET signaling pathway is crucial for the self-renewal and tumorigenic capacity of cancer stem cells, including glioblastoma stem cells (GSCs). Despite its recognized importance, the precise mechanisms of c-MET activation...

... at a dosage of 1 mg/kg exerts advantageous impacts on both the survival rate and neurocognitive performance of rats within the GBM model. However, our results showed that CBZ may have toxic effects, especially in a dose of 4 mg/kg. Graphical Abstract Graphical Abstract glioblastoma Temozolomide (TMZ...

... that circadian clock components, Brain and Muscle ARNT-Like 1 (BMAL1) and Circadian Locomotor Output Cycles Kaput (CLOCK), are essential for glioblastoma (GBM) stem cell (GSC) biology and survival. Consequently, we developed a novel Cryptochrome (CRY) activator SHP1705, which inhibits BMAL1-CLOCK transcriptional...

...Jainam Shah; Catherine Dunn; Grace Y Kim; Peter Gibbs; Lucy Gately Glioblastoma Quality Indicator Neuro-oncology Cancer Accepted Manuscript Evaluating current quality indicators used in the care of adult patients with glioblastoma: a scoping review of the literature Jainam Shah1, Catherine Dunn2...

... contact [email protected]. Abstract Background Early palliative care improves quality of life (QoL) and survival in patients with cancer; however, its effects in patients with glioblastoma remain unclear. The GLIOSUPPORT study assessed the feasibility (adherence; primary objective...

... IDH-mutant oligodendrogliomas, 44 IDH-mutant astrocytomas, and 36 IDH-wild-type glioblastomas exhibited distinct patterns of the IHC markers. In oligodendrogliomas, HIP1R showed either homogeneous or homogenous and mosaic staining, Vimentin was negative and H3K27me3 was lost in all cases...

... MGMT methylation data. Methods We developed a method to find the optimal gray zone using pyrosequencing MGMT methylation values (CpG sites 72-83) from 308 glioblastoma cases with overall survival data. Each integer below the methylated threshold defined a new possible gray zone and categorisation...

... and proneural genes, respectively. Conclusion Single-cell data suggest that MGMT expression falls on a continuous spectrum. A smaller percentage of tumor cells express MGMT when MGMTp is methylated. Glioblastoma single-cell sequencing MGMT spatial-transcriptomics...

..., Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Glioblastoma (GB) heterogeneity poses substantial challenges for diagnosis and treatment. Isocitrate dehydrogenase (IDH)-wildtype GB may lack contrast enhancement on MRI...