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Journal Article
Does the psychological risk exposure increase carotid plaque detection among the Chinese midlife population? A latent class and regression analysis
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Xinyu Gou and others
European Journal of Cardiovascular Nursing, zvaf061, https://doi.org/10.1093/eurjcn/zvaf061
Published: 23 April 2025
.../100007219 23ZR1463600 Anxiety Carotid plaque Depression Latent class analysis Midlife population Psychological risk Graphical Abstract Graphical Abstract Abstract Aims The aim of this study was to determine whether the psychological risk exposures increase carotid plaque detection...
Journal Article
Association of multimorbidity patterns and order of physical frailty and cognitive impairment occurrence: a prospective cohort study
Shuomin Wang and others
Age and Ageing, Volume 54, Issue 4, April 2025, afaf101, https://doi.org/10.1093/ageing/afaf101
Published: 23 April 2025
... participants were included and followed up for four years. Latent class analysis was conducted to identify multimorbidity patterns with clinical meaningfulness. Fine and Grey competing risks models were used to examine the associations between multimorbidity patterns and different orders of frailty and CI...
Journal Article
CD40 ligand: the essential link in B/T cell collaboration and immune activation
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Caroline Y Kuo
The Journal of Immunology, vkaf072, https://doi.org/10.1093/jimmun/vkaf072
Published: 22 April 2025
..., in 1993. https://www.nature.com/articles/361541a0 . CD40 ligand CD154 class switch recombination X-linked hyper IgM syndrome Hyperimmunoglobulin M (HIGM) syndrome was first reported in 1961 by Rosen et al., who described two male patients with recurrent infections found to have markedly low...
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Early life trauma patterns and adult epigenome-wide and NR3C1-specific DNA methylation in the Sister Study
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Jennifer M P Woo and others
American Journal of Epidemiology, kwaf076, https://doi.org/10.1093/aje/kwaf076
Published: 11 April 2025
... stress-related genes (e.g., glucocorticoid receptor gene, NR3C1). Data represent a case-cohort of non-Hispanic white participants (N=2,566) from the Sister Study, a cohort of US women (ages:35-74; enrollment:2003-2009; N=50,884). ELT measures included a count score and four latent ELT classes...
Journal Article
The politics of the Norwegian capitalist class: the inner circle and wealthy owners
Marte Lund Saga
Social Forces, soaf047, https://doi.org/10.1093/sf/soaf047
Published: 10 April 2025
... segments within the capitalist class, comparing an inner circle of interlocked directors to a list of Norwegian wealthy owners. Drawing on a unique dataset that combines data on corporate boards with political participation records, the study compares wealthy owners and an “inner circle” of corporate...
Journal Article
A Latent Class Analysis of Personality Traits in Adults Experiencing Homelessness
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Nathaniel A Dell and others
Social Work Research, svaf004, https://doi.org/10.1093/swr/svaf004
Published: 03 April 2025
... nationally representative data of the civilian, noninstitutionalized population of the United States, inclusive of those reporting past-year homelessness (N = 704). A bias-adjusted three-step latent class analysis was used to estimate latent class measurement models; classify cases into the optimal...
Journal Article
Estimating racial and ethnic healthcare quality disparities using exploratory item response theory and latent class item response theory models
Sharon-Lise Normand and others
Journal of the Royal Statistical Society Series A: Statistics in Society, qnaf033, https://doi.org/10.1093/jrsssa/qnaf033
Published: 01 April 2025
...-individuals. Balancing health differences across race and ethnicity groups is challenging due to confounding. We provide an approach addressing these features, utilizing exploratory multidimensional item response theory (IRT) models and latent class IRT models to estimate quality, and optimization-based...
Journal Article
Scalar implicature rates vary within and across adjectival scales
Helena Aparicio and Eszter Ronai
Journal of Semantics, ffaf002, https://doi.org/10.1093/jos/ffaf002
Published: 27 March 2025
..., the assumption being that higher thresholds should elicit higher degrees on average. The value of the threshold is thought to be fixed by reasoning about a contextually salient comparison class (CC) of individuals that often corresponds to the extension of the subject NP for predicative adjectives. The value...
Journal Article
ERAP1-dependent extreme antigen processing efficacy can govern MHC class I expression hierarchy
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Jacqueline Leib and others
The Journal of Immunology, vkaf013, https://doi.org/10.1093/jimmun/vkaf013
Published: 27 March 2025
... Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Peptide presentation by major histocompatibility complex (MHC) class I molecules enables CD8+ T lymphocytes to monitor the intracellular proteome of tissue cells. CD8+ T cell priming...
Journal Article
Benchmarking ensemble machine learning algorithms for multi-class, multi-omics data integration in clinical outcome prediction
Annette Spooner and others
Briefings in Bioinformatics, Volume 26, Issue 2, March 2025, bbaf116, https://doi.org/10.1093/bib/bbaf116
Published: 21 March 2025
... integration of multi-class data from different modalities. The ensemble methods and their variations tested were (i) a voting ensemble, with hard and soft vote, (ii) a meta learner, and (iii) a multi-modal AdaBoost model using hard vote, soft vote, and meta learner to integrate the modalities on each boosting...
Journal Article
Long-term comparison of maxillary protraction with hybrid hyrax-facemask vs. hybrid hyrax-mentoplate protocols using Alt-RAMEC: a 5-year randomized controlled trial
Joeri Meyns and others
European Journal of Orthodontics, Volume 47, Issue 2, April 2025, cjaf011, https://doi.org/10.1093/ejo/cjaf011
Published: 19 March 2025
...-center 2-arm parallel randomized controlled trial. Participants: 28 skeletal class III patients (female: 14, male: 14; average age: 9.7 ± 1.3 years;) were included. Interventions: Two treatment groups where protraction therapy was combined with Alt-RAMEC. Group 1: Facemask group (Hybrid...
Journal Article
Tuning ProteinMPNN to reduce protein visibility via MHC Class I through direct preference optimization
Hans-Christof Gasser and others
Protein Engineering, Design and Selection, Volume 38, 2025, gzaf003, https://doi.org/10.1093/protein/gzaf003
Published: 18 March 2025
...) recognition and presentation by the MHC Class II (MHC-II) pathway will be most relevant. On the other hand, some therapeutics will have to be expressed within human cells, e.g. mRNA therapeutics aimed at mitigating an issue within the cell. In these cases avoiding detection by cytotoxic T-lymphocytes (CTLs...
Journal Article
IL-2Rα is dispensable for murine B cell development and humoral response
Priyanka Chowdhury and others
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 694–702, https://doi.org/10.1093/jimmun/vkae045
Published: 17 March 2025
... found that the loss of CD25 had no impact on B cell development, homeostasis, or immune response to model antigens. Additionally, while CD25 expression was upregulated in activated splenic B cells, its absence did not affect class switch recombination in vitro or in vivo. We conclude...
Journal Article
Do financial regulators act in the public’s interest? A Bayesian latent class estimation framework for assessing regulatory responses to banking crises
Padma Sharma and Trambak Banerjee
Journal of the Royal Statistical Society Series A: Statistics in Society, qnae150, https://doi.org/10.1093/jrsssa/qnae150
Published: 12 March 2025
... information on the two US banking regulators, review the recommended decision rules from theoretical studies and summarize the main contributions of our work. In Section 3 , we discuss the data used in this article. Section 4 presents the proposed Bayesian latent class estimation framework for evaluating...
Journal Article
Spatially-dense three-dimensional analysis of the midfacial skeletal shape asymmetry in skeletal Class III patients
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Guangpu Zhao and others
European Journal of Orthodontics, Volume 47, Issue 2, April 2025, cjaf010, https://doi.org/10.1093/ejo/cjaf010
Published: 10 March 2025
... aimed to analyze midfacial skeletal shape asymmetry in skeletal Class III patients using a three-dimensional spatially-dense method. Methods Sixty skeletal Class III patients’ cone-beam computed tomography images were retrospectively enrolled and divided into three groups according to occlusal plane...
Journal Article
A classification using CRP and AFP in predicting survival of early- and intermediate-stage HCC treated with TACE
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Manabu Hayashi and others
Japanese Journal of Clinical Oncology, hyaf041, https://doi.org/10.1093/jjco/hyaf041
Published: 05 March 2025
.... C-reactive protein alpha-fetoprotein CRP-AFP class hepatocellular carcinoma transcatheter arterial chemoembolization C-reactive protein—alpha-fetoprotein classification was independently associated with prognosis and maybe a simple prognostic tool for post-transcatheter arterial...
Journal Article
Demographic and work-related correlates of general and workplace loneliness among employees in Japan: a large-scale descriptive cross-sectional study
Norito Kawakami and others
Journal of Occupational Health, Volume 67, Issue 1, January-December 2025, uiaf015, https://doi.org/10.1093/joccuh/uiaf015
Published: 04 March 2025
... age and working long hours may be factors for workplace loneliness, independent of general loneliness, in Japan. prevalence of loneliness age social class industrial sectors work hours Japan Science and Technology Agency (JST) 10.13039/501100002241 Ministry of Health, Labour, and Welfare...
Journal Article
Virulent African swine fever virus infection of porcine monocytes causes SLA I subversion due to loss of proper ER structure/function
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Luise Brose and others
The Journal of Immunology, Volume 214, Issue 3, March 2025, Pages 532–550, https://doi.org/10.1093/jimmun/vkae063
Published: 28 February 2025
... are characterized by lower levels of swine leukocyte antigen (SLA) class I on the cell surface than ASFV-E-infected and uninfected monocytes. Despite stable steady-state SLA I mRNA/protein levels and expression of critical components of the antigen processing machinery, a marked decrease in maturation and reduced...
Journal Article
Structure of naval officer corps in modern Japan: formation through education and examinations
Norifumi Takeishi
Social Science Japan Journal, Volume 28, Issue 1, Winter 2025, jyae037, https://doi.org/10.1093/ssjj/jyae037
Published: 27 February 2025
... corps were traditionally expected to be composed of individuals from the ‘officer-capable class’. By contrast, the Japanese navy, from its inception, prioritized ability over ascribed status. Officer candidates, therefore, underwent rigorous entrance examinations, and at the Naval Academy, cadets faced...
Journal Article
Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression
Maren Heimerl and others
European Heart Journal, ehaf047, https://doi.org/10.1093/eurheartj/ehaf047
Published: 19 February 2025
..., and reproduction in any medium, provided the original work is properly cited. Abstract Background and Aims The present study analysed the expression patterns of class-5 myosin motor proteins (MYO5a, b, and c) in the heart with a specific focus on the role of MYO5b. Methods RNA-sequencing, quantitative real...
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