... with Parkinson’s disease, the connectivity between the two primary motor cortices may be altered. However, the correlation between asymmetries of abnormal interhemispheric connections and bradykinesia features has not been investigated. Furthermore, the potential effects of dopaminergic medications on this issue...

..., Mountain View, CA, USA) optical tracking sensor to capture real-time hand location and assess the motor features of bradykinesia. A knowledge of time-variant hand coordinates from the LMC sensor allowed us to quantify hand motion and evaluate the different motor features of bradykinesia independently. LMC...

...Andrea Guerra; Donato Colella; Margherita Giangrosso; Antonio Cannavacciuolo; Giulia Paparella; Giovanni Fabbrini; Antonio Suppa; Alfredo Berardelli; Matteo Bologna Guerra et al. demonstrate that enhancing β and γ oscillations in motor cortex has differential effects on bradykinesia...

... in bradykinesia were contingent on reduction of beta power and burst durations, and/or the volume of the sensorimotor subthalamic nucleus that was modulated. We recorded synchronized local field potentials and kinematic data in 16 subthalamic nuclei of individuals with Parkinson’s disease chronically implanted...

... power in Parkinson’s disease can be explained—primarily by changes in the underlying burst rate. Importantly, our results also revealed a relationship between beta burst rate and motor symptom severity in Parkinson’s disease: a lower burst rate scaled with increased severity of bradykinesia and postural...

...Matteo Bologna; Giulia Paparella; Alfonso Fasano; Mark Hallett; Alfredo Berardelli A further issue is the role of secondary contributing factors to bradykinesia, and their burden in the clinical evaluation of bradykinetic patients. It has been suggested that in Parkinson’s disease weakness can...

... correlated with UPDRS III and bradykinesia improvement. Stimulation of the smaSTN segment, but not the m1STN one, had a positive correlation with bradykinesia improvement. Stimulation of the nmSTN segment was negatively correlated with the improvement in rigidity. Stimulation outside of the STN...

.... Figure 1 Pallidal DBS is an effective therapy for dystonia, but anecdotal evidence suggests that it may lead to specific parkinsonian symptoms. Mahlknecht et al. report that bradykinesia and axial motor signs in particular are frequent among dystonia patients undergoing pallidal DBS...

..., 00185 Rome, Italy E-mail: [email protected] Figure 1 Whether neurophysiological abnormalities in the primary motor cortex (M1) contribute to bradykinesia in patients with Parkinson’s disease is unclear. Bologna et...

...) in nigrostriatal terminals, in contrast to ~70%–80% loss associated with bradykinesia onset in Parkinson’s disease. These studies evaluated the effect of ~6 months 30% calorie restriction (CR) on nigrostriatal DA regulation and aging-related locomotor decline initiated at 12 months of age in Brown-Norway Fischer...

... in motor control in Parkinson’s disease. The findings provide insights into the pathophysiology underlying bradykinesia and deficits in executive function, and help to explain why dopaminergic treatments have a greater effect on the former. Abstract Although characteristic motor symptoms of Parkinson’s...

...Helen Ling; Luke A. Massey; Andrew J. Lees; Peter Brown; Brian L. Day Bradykinesia is a sine qua non for the diagnosis of Parkinson's disease. In clinical practice, the term bradykinesia is often used interchangeably with the terms akinesia and hypokinesia. Nevertheless, bradykinesia...

...Caterina Rosano; David A. Bennett; Anne B. Newman; Vijay Venkatraman; Kristine Yaffe; Tamara Harris; Stephen Kritchevsky; Howard J. Aizenstein In this sample of 307 participants, 44% (N = 133) had bradykinesia, gait disturbances, or tremor, 25% had bradykinesia, 25% had gait disturbances...

... of the diagnosis of Parkinson's disease was established in each case, as well as the duration of symptoms at diagnosis. Disease onset was defined as the time of first recalled motor symptoms. The pattern of motor deficits (tremor, bradykinesia and rigidity) in the pre-treatment phase of the disease was determined...

... of contralateral prelemniscal radiations (Raprl) in patients with unilateral Parkinson's disease. The present study determines the effect of bilateral Raprl electrical stimulation in a group of patients with severe bilateral tremor, rigidity, and bradykinesia. METHODS Five patients with Parkinson's disease...

... of Illinois at Chicago, 901 West Roosevelt Road, Chicago, IL 60608, USAE‐mail: [email protected] The Guarantors of Brain 2003 2004 Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and antiparkinsonian medication (Meds) have proved to be effective therapies for treating bradykinesia...

...A. Berardelli; J. C. Rothwell; P. D. Thompson; M. Hallett Professor Alfredo Berardelli, Dipartimento di Scienze Neurologiche, Viale Università 30, 00185 Roma, Italy 31 05 2001 10 08 2000 05 05 2001 © Oxford University Press 2001 2001 Abstract Bradykinesia means slowness of movement...

... walking. A few patients had mild bradykinesia in the form of slowness of movement and instability while walking on an inclined plane. All patients had received different combinations of medication that invariably included l-dopa preparations that had induced various degrees of improvement, but either...

... finger movements have little or no reliance on external cues and as such are internally generated movements. Decay in the amplitude of such movements and slowness in their execution is a cardinal clinical feature of parkinsonian bradykinesia. Right and left hands were examined. Off-line analysis...

... related to motor unit behavior in Parkinson's disease (PD). The focus is on bradykinesia, or slowed movement. There is sparse literature on muscular performance in PD, as PD is regarded as a disease of higher motor centers. Nevertheless, a decrease in muscle activation has been demonstrated, and motor...