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Journal Article
Evaluation of 6 monoclonal antibodies against Ser129-phosphorylated α-synuclein: Critical role of proteinase K antigen retrieval and superior sensitivity of the D1R1R clone in human skin biopsies
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Cecilia Delprete and others
Journal of Neuropathology & Experimental Neurology, nlaf036, https://doi.org/10.1093/jnen/nlaf036
Published: 22 April 2025
... bodies, and multiple system atrophy (MSA). Misfolded-α-synuclein inclusions that contain high levels of Serine-129 phosphorylated (pS129-α-syn) are key diagnostic markers. Skin biopsies are a promising peripheral tissue for in vivo detection of aggregates using immunofluorescence staining. Several...
Journal Article
Upfront liquid biopsy in patients with advanced solid tumors who were not feasible for tissue-based next-generation sequencing
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Akito Fukuda and others
Japanese Journal of Clinical Oncology, hyaf065, https://doi.org/10.1093/jjco/hyaf065
Published: 19 April 2025
...: [email protected]. 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Liquid biopsy has been developed as an alternative to tissue...
Journal Article
Present and future of endomyocardial biopsy in cardiac amyloidosis
Maurizia Grasso and others
European Heart Journal Supplements, Volume 27, Issue Supplement_3, March 2025, Pages iii7–iii12, https://doi.org/10.1093/eurheartjsupp/suaf036
Published: 16 April 2025
...-A, and beta2-microglobulin. Endomyocardial biopsy (EMB), still considered the gold standard for diagnosing and typing amyloid, is primarily reserved for cases where non-invasive tools do not provide a definitive diagnosis. Interestingly, while EMB was expected to decline, its numbers have increased globally...
Journal Article
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Air embolism after CT-guided transthoracic interventional operation: Is it necessary to change the patient's position to prevent embolized air from entering the systemic circulation
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Ran Yan and others
British Journal of Radiology, tqaf078, https://doi.org/10.1093/bjr/tqaf078
Published: 10 April 2025
... into the systemic circulation after air embolism (AE). Materials and methods 116 patients with AE were selected as study subjects, including 81 patients undergoing CT-guided transthoracic biopsy and 35 patients undergoing CT-guided localization of pulmonary nodule before video-assisted thoracoscopic surgery...
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Case Report on Heart Transplantation in Endomyocardial Fibrosis: “Do not let your guard down”. Suspicion of Disease Recurrence after heart transplantation
Lorena Herrador and others
European Heart Journal - Case Reports, ytaf149, https://doi.org/10.1093/ehjcr/ytaf149
Published: 02 April 2025
... and the endomyocardial biopsy (EMB) showed extensive inflammation and myocardial damage, compatible with grade 2R (G3a) cellular rejection. After steroid pulses, the follow-up EMB reveal subendocardial fibrosis and microcalcifications, suggesting the possibility of a EMF recurrence. Nevertheless, the patient had a good...
Journal Article
Profiling mitochondrial DNA variant segregation during human preimplantation development: a prerequisite to preimplantation genetic testing for mitochondrial DNA-related disorders
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Paula Rubens and others
Human Reproduction, deaf050, https://doi.org/10.1093/humrep/deaf050
Published: 02 April 2025
..., METHODS As part of clinical PGT, a blastomere biopsy was performed at cleavage or early compaction stages (Day 3 or 4) on 112 ‘mito’ and 21/28 control embryos. Further analysis was carried out at Day 5 or 6 on 51 embryos deemed unsuitable for uterine transfer and donated to research. Heteroplasmy levels...
Journal Article
Imaging, Patient, and Diagnostic Radiologist Factors Associated With Malignancy for Mammographic Asymmetries Undergoing Biopsy
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Allyson L Chesebro and others
Journal of Breast Imaging, wbaf008, https://doi.org/10.1093/jbi/wbaf008
Published: 01 April 2025
... biopsy revealed microinvasive carcinoma. Table 1. Multiple Logistic Regression Model for Imaging and Patient Features Associated With Likelihood of Malignancy in 247 Biopsy-Proven Mammographic Asymmetries Features and factors Pathology outcome OR (95% CI) P...
Journal Article
Pulmonary amyloidosis: a case report
Fenna Ahsino and others
Oxford Medical Case Reports, Volume 2025, Issue 4, April 2025, omaf007, https://doi.org/10.1093/omcr/omaf007
Published: 28 March 2025
... dyspnea for three months and a chest CT scan revealed a pulmonary nodule in the middle lobe. She underwent CT-guided biopsy and diagnosis of pulmonary amyloidosis was retained by histology. Follow up has been unremarkable. amyloidosis lung nodule dyspnea biopsy Amyloidosis is a heterogeneous group...
Journal Article
Liquid biopsy in lung cancer
Shingo Kitagawa and Masahiro Seike
Japanese Journal of Clinical Oncology, hyaf013, https://doi.org/10.1093/jjco/hyaf013
Published: 19 March 2025
...Shingo Kitagawa; Masahiro Seike Corresponding author. Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo 113-8603, Japan. E-mail: [email protected] . Guardant360® CDx, a liquid biopsy approved by the FDA in 2016...
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Evaluating liquid biopsy biomarkers for early detection of brain metastasis: a systematic review
Jinyue Yu and others
Neuro-Oncology Practice, npaf032, https://doi.org/10.1093/nop/npaf032
Published: 18 March 2025
... is critical for optimizing treatment and improving survival. This systematic review evaluates the diagnostic potential of liquid biopsy biomarkers for detecting BM from lung, breast, and other cancers. Methods A comprehensive search was conducted in MEDLINE, Embase, and BIOSIS databases using keywords...
Journal Article
Impact of female sexual dysfunctions on women undergoing pipelle endometrial biopsy and endocervical curettage for abnormal uterine bleeding: a prospective cross-sectional study
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Sevim Baltali and others
The Journal of Sexual Medicine, qdaf037, https://doi.org/10.1093/jsxmed/qdaf037
Published: 17 March 2025
...%, respectively, of women with “insufficient” samples. 9 , 10 Older age-associated atrophic endometrium, patient pain tolerance, and provider inexperience performing endometrial biopsies are associated with biopsy failure (BF). 6 , 7...
Journal Article
Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC
Sean M Davidson and others
Cardiovascular Research, cvaf023, https://doi.org/10.1093/cvr/cvaf023
Published: 14 March 2025
..., translational and basic scientists engaged in cardiovascular research. Graphical Abstract Graphical Abstract Created in BioRender. Davidson, S. (2023) BioRender.com/s89d477 . Cardiovascular Cardiovascular disease Translational research Human Myocardium Vascular Valve Blood Biopsy Biobank iPSCs...
Journal Article
Why, how and when to look for occult giant cell arteritis in patients with polymyalgia rheumatica
Daniel Blockmans
in
Rheumatology
Rheumatology, Volume 64, Issue Supplement_1, March 2025, Pages i55–i58, https://doi.org/10.1093/rheumatology/keae513
Published: 12 March 2025
... arteritis vasculitis positron emission tomography ultrasound temporal artery biopsy Rheumatology key messages Subclinical vasculitis is found in 9–23% of patients with pure PMR, depending on the imaging method used and the criteria used for defining vasculitis. Patients with pure PMR...
Journal Article
Biopsy vs comprehensive embryo/blastocyst analysis: a closer look at embryonic chromosome evaluation
Jian Xu and others
Human Reproduction Open, Volume 2025, Issue 2, 2025, hoaf013, https://doi.org/10.1093/hropen/hoaf013
Published: 12 March 2025
... License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract STUDY QUESTION Compared with embryonic cytogenetic constitution of biopsied samples in human pre-implantation...
Journal Article
Cutaneous lupus erythematosus presenting as a nonhealing ulcer in an African American woman: A case report
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Kevin M Burningham and others
American Journal of Clinical Pathology, aqaf017, https://doi.org/10.1093/ajcp/aqaf017
Published: 12 March 2025
... disorder of the skin. Methods In this report, we describe the case of an African American woman with CLE who had an ulcer on her posterior thigh. Despite this, initial biopsy specimen of the lesion revealed no evidence of CLE until a repeat biopsy 5 months later. Conclusions This case underscores...
Journal Article
Biopsy vs imaging for the diagnosis of giant cell arteritis. Viewpoint 2: in favour of biopsy
Georgina Espígol-Frigolé and others
in
Rheumatology
Rheumatology, Volume 64, Issue Supplement_1, March 2025, Pages i74–i78, https://doi.org/10.1093/rheumatology/keae474
Published: 12 March 2025
... This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Objectives Both temporal artery biopsy (TAB) and imaging are widely used to support the diagnosis...
Journal Article
Biopsy vs imaging in the diagnosis of giant cell arteritis. Viewpoint 1: in favour of imaging
Wolfgang Andreas Schmidt
in
Rheumatology
Rheumatology, Volume 64, Issue Supplement_1, March 2025, Pages i71–i73, https://doi.org/10.1093/rheumatology/keae487
Published: 12 March 2025
...Wolfgang Andreas Schmidt giant cell arteritis large-vessel vasculitis polymyalgia rheumatica ultrasound magnetic resonance imaging computed tomography positron emission tomography angiography temporal artery biopsy histology Updated EULAR Recommendations on Imaging in Large-vessel...
Journal Article
The prevalence of immunoglobulin A nephropathy in the European Union and the impact of the COVID-19 pandemic: an estimation approach utilizing the kidney biopsy frequency
Jocelyn Buisker and others
Clinical Kidney Journal, Volume 18, Issue 4, April 2025, sfaf068, https://doi.org/10.1093/ckj/sfaf068
Published: 28 February 2025
... in the population during the same year. The annual biopsy rate was similarly defined by the number of patients undergoing a native kidney biopsy for any reason in 1 year divided by the population at risk during the same year. If incidence or biopsy rates were not directly reported, they were calculated based...
Journal Article
A giant epidermal cyst preoperatively diagnosed by core needle biopsy
Toshiyuki Yamaguchi
Journal of Surgical Case Reports, Volume 2025, Issue 2, February 2025, rjaf088, https://doi.org/10.1093/jscr/rjaf088
Published: 27 February 2025
.... They rarely grow >5 cm in diameter and are referred to as giant epidermal cysts. Although soft tissue tumors >5 cm are recommended for imaging examination and biopsy preoperatively, biopsy of giant epidermal cysts has rarely been performed because of the complications that may arise when non-absorbable...
Journal Article
Feasibility and safety of interventional radiology-guided biopsy for esophageal stenosis
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Gang Zhou and others
Diseases of the Esophagus, Volume 38, Issue 1, February 2025, doaf005, https://doi.org/10.1093/dote/doaf005
Published: 27 February 2025
...-rights ) Summary Background Endoscopic clamp biopsy is generally performed to confirm the pathological diagnosis of esophageal stenosis. However, it might be challenging in patients with severe esophageal stenosis. Hence, we aimed to investigate the feasibility and safety of interventional radiology...
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