... their significance, investigating the pathogen-driven evolution of HLAs and the implications for autoimmune diseases presents considerable challenges. Here, we genotyped over twenty HLA genes at 3-field resolution in 8278 individuals from diverse ethnic backgrounds, including 4013 unrelated Han Chinese. We focused...

... is properly cited. See the journal About page for additional terms. Abstract Context Autoimmune hypothyroidism, commonly known as Hashimoto’s thyroiditis (HT), is an autoimmune thyroid disorder affecting approximately 5% of the United States population. Previous relative risk (RR) studies have suggested...

... in the immune response to infections, STING is also surprisingly at the center of a variety of non-infectious human diseases, including cancer, autoimmune diseases and neurodegenerative diseases. Recent studies have shown that STING has many signaling activities, including type I interferon (IFN-I) and other...

... upregulates T cell receptor (TCR)-mediated T cell activation by interacting with LCK and phospholipase C-γ1 and affecting autoimmune demyelination and airway inflammation. In this study, we aimed to generate a new STAP-1-derived peptide, iSP1, to inhibit the STAP-1–LCK interaction. We also analyzed its...

.../pages/standard-publication-reuse-rights ) Abstract Autoimmune regulator (AIRE), a transcriptional regulator expressed by medullary thymic epithelial cells, is required for shaping the self-antigen tolerant T cell receptor repertoire. In humans, AIRE mutations caues autoimmune polyglandular...

... the demographics, clinical characteristics, and care patterns of patients with systemic autoimmune rheumatic diseases (SARD) prior to their interstitial lung disease (ILD) diagnosis. Methods We conducted a retrospective cohort study using claims data from Healthcare Integrated Research Database (2006–2023...

...) as akinetic, with residual contractility only on the basal segments, suggestive of Takotsubo Cardiomyopathy (TCM) as a likely diagnosis. This is on a backdrop of a complex history of autoimmune and chronic inflammatory comorbidities, including type 1 diabetes, asthma, sarcoidosis, primary biliary cholangitis...

.... Thus, the retrieved data indicate a significant involvement of T cells in the disease pathology of SSc- and SjD-associated ILD. Systemic sclerosis Sjögren’s disease interstitial lung disease systemic autoimmune rheumatic disease T cells terminally differentiated effector memory dendritic cells...

... in the development of chronic pediatric conditions, but many studies leave concerns about unmeasured confounding. We evaluated associations between early-childhood antibiotic exposure and allergic, autoimmune, or neurodevelopmental/psychiatric conditions. Methods We performed a retrospective cohort study using...

... lessons learned, potential solutions and outline areas for future development. Finally, we discuss how the field of engineered cell therapy is moving into the treatment of solid tumors and other diseases beyond cancer. autoimmune disease cancer chimeric antigen receptor T-cell therapy immunotherapy...

[email protected]. 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Patients with autoimmune and autoinflammatory diseases experience difficult physical...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by a wide range of clinical and immunologic manifestations, most prominently, the production of autoantibodies to nuclear components (ANAs). A previous...

... License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms. Abstract Type 1 diabetes (T1D) is an autoimmune disease with 2...

... erythrocyte destruction are present in patients with cold autoimmune hemolytic anemia (cAIHA). The diagnosis of cAIHA is challenging because of the rarity of the disease, especially in patients with nonspecific features. Methods In this case report, we discuss an unusual case of cAIHA in an older man who...

... are fibroinflammatory disorders affecting multiple organs, with autoimmune pancreatitis (AIP) being a common manifestation. Steroid therapy is effective in inducing remission but has complex effects on glucose metabolism. Diabetes occurs in 40% to 80% of AIP patients, and steroids can worsen glucose tolerance, although...

..., Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Autoimmune hepatitis (AIH) is an autoimmune disease mediated by abnormal autoimmune. The pathogenesis and pathological manifestation of immune-mediated liver injury, induced by concanavalin...

... unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Anti-Leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) autoimmune encephalitis (AIE) are common and characterized by pathogenic antibodies targeting...

... is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Objective The risk of autoimmune disease could be increased in transgender (TG) persons and could be affected by TG...

... severity. These findings elucidate the need for personalised management and longitudinal studies. Anti-SS-B/la antibodies autoimmune disease disease activity assessment disease heterogeneity ESSDAI (European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index) Hashimoto’s disease...

... Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease that is believed but not confirmed to have an autoimmune origin. Since its discovery nearly two decades ago, our...