... . et al.   Invasive infections caused by Saprochaete capitata in patients with haematological malignancies: report of five cases and review of the antifungal therapy . Rev Iberoam Micol   2013 ; 30 : 248 – 55 . 10.1016/j.riam.2013.02.004 . 2. Noster   J , Koeppel   MB , Desnos...

... Graphical Abstract Figure. Proteomic analyses of the human pathogenic fungus Aspergillus fumigatus revealed that the antifungal amphotericin B leads to the activation of an antibacterial response and the production of the RTA-like protein RtaA, which probably contributes to the stability of the cell...

... Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Introduction Antimicrobial resistance (AMR) is an emerging crisis worldwide. If continued, it is estimated AMR could cause over 10 million deaths annually by 2050¹. Antifungals are critical...

... metabolites antibiotics antifungals Fungus-farming ants (Formicidae: Myrmicinae: Attini) are of great scientific interest due to the symbiotic interactions they have established with various microorganisms. It is important to highlight the quadripartite symbiosis developed by (i) the ants; (ii...

... by attending to this epidemiologic problem in Mexico, based on publications about the outbreak. Likewise, I discuss the latest publication regarding invasive fusariosis in Mexico, unrelated to the outbreak. antifungals fungal meningitis fusariosis Mexico outbreak Mexico has been in the spotlight regarding...

... in Table 2 , older age (≥60 years), liver cirrhosis, and need for mechanical ventilation or vasopressor support use had statistically significant associations with inpatient all-cause mortality. Previous knowledge of coccidioidomycosis diagnosis before ICU admission, use of antifungal therapy before ICU...

... in immunosuppressed patients [ 3–7 ]. Treatment can be challenging and often requires surgical debridement or prolonged courses of antifungal medications that have the potential for drug–drug interactions and toxicities. Prototheca contains ergosterols within its cell wall, allowing for treatment...

... at the 2022 meeting, with emphasis on novel host risk factors, emerging resistant fungal pathogens, the evolving antifungal pipeline, and critical issues affecting the advancement of mycology research. Clinical mycology is at a pivotal inflection point, with expanding patient populations at risk of fungal...

... adverse effects. It appears to provide a safer treatment option for patients requiring therapy with AmB for weeks to months, and the oral formulation allows patients to be treated in the outpatient setting. It may be particularly promising for infections that are often resistant to antifungal agents other...

... be practiced. More studies are needed to evaluate the role of newer antifungal agents, use of combination antifungal regimens, and impact on morbidity in patients with LVADs. antifungals Candida auris candidemia heart transplant left ventricular assist device Cases are summarized in Table 2...

... of novel antifungal agents recently approved for use or in late stages of clinical development. The overarching goal of this review is to discuss the mechanisms of action, spectrum of activity, stage of development, and pediatric-specific data for the following agents: encochleated amphotericin B...

..., age, gender, and percentage of body surface area affected were all recorded, along with the areas of infection, fungus species implicated, antifungal therapies, and clinical results. When possible, real-time PCR data from recent molecular diagnostics were also included. Initially, 81 records were...

... refractory, alemtuzumab. Patients treated with alemtuzumab received systemic antifungal prophylaxis with a mold-active azole. This study had 3 primary outcomes: (1) IC within 90 days of lung transplantation (early IC), (2) IMI within 90 days of lung transplantation (early IMI), and (3) IMI between 90 days...

... patients with low incomes. ²⁴ A lack of resources in the healthcare system versus a large number of patients at risk may hinder access to appropriate diagnostic tools and antifungal treatments. ²⁵ Therefore, we aimed to monitor the current status of diagnostic and treatment tools...

... , Kontoyiannis DP . Tolerability of isavuconazole after posaconazole toxicity in leukaemia patients . Mycoses . 2019 ; 62 : 81 – 86 . 13. Furfaro E , Signori A , Di Grazia C et al. Serial monitoring of isavuconazole blood levels during prolonged antifungal therapy . J...

...Harshani Jayawardena-Thabrew; Adilia Warris; The PASOAP Group; Laura Ferreras-Antolin Abstract The indications for nystatin as prophylaxis or treatment are limited. In the PASOAP (Pediatric Antifungal Stewardship Optimizing Antifungal Prescription) study, high use of nystatin in hospitalized...

... diagnosis. The controversial efficacy of the currently available strategies for their clinical management, apart from their high toxicity and severe side effects, has renewed the interest in the research and development of new broad antifungal alternatives. These encompass vaccines and passive immunization...

... of treatments designed to address an unmet need for rare pathogens when traditional phase 3 trials are not feasible. alternate statistical criteria antibiotics antifungals small trials unmet need Traditional phase 3 trials confirm safety and efficacy of a new treatment relative to an active comparator...

...:https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstract There is an urgent need to develop novel antifungals. In this study, we screened 1600 compounds for antifungal activity against Cryptococcus neoformans and Candida auris. We evaluated 4...

... of novel, candidate antifungal agents for C. auris therapeutics. This narrative review codifies the emerging data on the following new/emerging antifungal compounds and strategies: antimicrobial peptides, combinational therapy, immunotherapy, metals and nano particles, natural compounds...