...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background Antidepressants are used by 60% of residents of long-term care facilities (LTCFs). Mirtazapine and sertraline are the most...

... The aim of this project is the validation of genomic and non-genomic biomarkers for predicting antidepressant treatment outcome to identify biologically more homogenous subgroups of patients that might benefit from specific treatments targeting the identified biomarker system. Based on previous findings...

... Background Vortioxetine, a newer serotonergic antidepressant, has been used to treat adult depressive patients. It has been reported to enhance cognitive functions in patients. While the precise mechanism of action remains unknown, it’ s believed to share similarities with selective serotonin reuptake...

... of depressive patients[1,2]. However, the underlying mechanism of this potential antidepressant is still largely unclear. Here, we studied the antidepressant-related actions of BTRX- 246040 in the ventrolateral periaqueductal gray (vlPAG). Methods The tail suspension test, forced swim test, female urine...

...*Tamayo Kobayashi; Fumitoshi Kodaka; Junpei Ishii; Keisuke Mori; Chihiro Saeki; Yoshiyuki Sakai; Masahiro Shigeta pregnancy database study anxiolytics and hypnotics antidepressant Abstract Background "The Guide for the Care of Pregnant Women with or Potentially With Psychiatric Disorders...

...*Nozomi Tokunaga; Yoki Nakamura; Kazue Hisaoka-Nakahsima; Norimitsu Morioka antidepressant connexin43 astrocyte Abstract Background The number of depression patients is increasing, which is one of the society problems in the world. In general, antidepressants affect through the increase...

... through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. methoxphenidine dissociative anaesthetics antidepressant pharmacokinetics Abstract Background Methoxphenidine (MXP) is a new psychoactive...

... on depressive-like behavior using behavioral, pharmacological, and biochemical assays. Methods We measured the duration of immobility of mice in the tail suspension test following their intracerebroventricular administration to determine whether DIZE or Ang (1-7) produce antidepressant- like effects. Next...

... contact [email protected]. Abstract Background Immune-inflammatory mechanisms are promising targets for antidepressant pharmacology [1-3]. Based on reported immune cell abnormalities, we defined an antidepressant potentiation treatment with add-on low-dose interleukin 2 (IL-2), a T-cell...

...). Conversely, the initiation of treatment with blonanserin significantly decreased AIWG incidence (HR = 0.49, 95% CI = 0.24–0.98). In terms of antidepressants, the combination of trazodone (HR = 2.53, 95% CI = 1.17–5.50), selective serotonin reuptake inhibitor (HR = 2.30, 95% CI = 1.46–3.64), and mirtazapine...

...*Samar Salah Mohamedahmed Elsheikh; Victoria Marshe; James Kennedy; Guillaume Paré; Corinne Fischer; Daniel Felsky; Daniel Mueller late-life depression antidepressant response polygenic risk score Abstract Background Our understanding of the interplay between genetic and environmental factors...

... increases cell excitability without drastically modifying bursting and firing frequency ( Pelletier 2014). As the medial prefrontal cortex (mPFC) is crucial for the antidepressant response, mPFC-tDCS has been explored as a potential therapeutic strategy for major depression (Thibault 2021). Previous...

... for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background Antidepressant use during pregnancy has been increasing in the last few decades...

[email protected]. Abstract Background Whereas ketamine's antidepressant effect for treatment-resistant depression (TRD) has been consistent in the literature from the North American and European countries (1-3), its evidence is scarce among the Asian population (4-6). Aims & Objectives We aimed...

... Reuptake Inhibitor/SNRI. There is a lack of studies investigating the effectiveness and safety of ESK-NS in combination with other oral antidepressants. The recent surge in the utilization of ESK-NS in clinical environments (2; 3; 4) has sparked interest in conducting fresh investigations to assess...

... permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected]. Abstract Background Antidepressant (AD) resistant depression is a major cause of disability. We have recently identified...

... of LSD were significantly counteracted by a prior administration of RS 127445. Conclusion Collectively, the present results suggest for the first time that 5-HT2B receptors play a permissive role in the antidepressant effects of serotonergic psychedelics. References [1]Passie T, et al. (2008) CNS...

... have been shown to affect antidepressant-like effects in a number of animal models. The tail suspension test (TST) and the forced swim test (FST) were used to examine the roles of MOP and DOP in hopeless emotional effects MOP-KO mice and WT mice were treated with KNT-127, a selective DOP agonist...

...Zhenlong Li; Hsien-Yu Peng; Chau-Shoun Lee; Tzer-Bin Lin; Ming-Chun Hsieh; Cheng-Yuan Lai; Han- Fang Wu; Lih-Chyang Chen; Mei-Ci Chen; *Dylan Chou methylone antidepressant depressive-like behavior sociability Abstract Background Methylone (3,4-methylenedioxy-N-methylcathinone) is a rapid...

... to validated stress protocols [1]. Chronic Mild Stress (CMS) is one of the most widely used animal models of depression to study both etiopathogenetic and antidepressant mechanisms. Recently, the NMDA receptor antagonist ketamine has emerged as the first rapid-acting antidepressant drug effective in patients...