... of Rheumatology, Mayo Clinic, Mayo Building, 15th Floor East 200 First St. SW Rochester, MN 55905,  USA. E-mail: [email protected] Abstract Objectives Whipple’s disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration...

... image(s) and associated text has been obtained from the patient in line with COPE guidance. Conflict of interest: none declared. References 1 Dolmans RA , Boel CH , Lacle MM , Kusters JG. Clinical manifestations, treatment, and diagnosis of Tropheryma whipplei...

... Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Whipple disease Tropheryma whipplei urine sample pneumonia gastroenteritis ( See the Major Article by Moter et al on pages 1089–97 .) Whipple disease...

... they were grouped to the controls. Samples from all remaining 43 participants, including the index patient, were referred to the German Consiliary Laboratory (Deutsches Herzzentrum Berlin) and Charité–Universitätsmedizin Berlin for Tropheryma whipplei testing and were categorized into 3 groups...

... medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected] Abstract Background Whipple disease (WD), a rare systemic infection caused by Tropheryma whipplei, can...

.... For Permissions, please e-mail: [email protected] 2013 Abstract Objectives Patients with classic Whipple's disease have a lifetime defect in immunity to Tropheryma whipplei and frequently develop treatment failures, relapses or reinfections. Empirical treatments were tested before culture...

... 2012 Abstract Whipple's disease, caused by the bacterium Tropheryma whipplei, is a rare chronic multi-system illness commonly affecting the gastrointestinal (GI) tract and presenting with a triad of diarrhoea, weight loss and malabsorption. While 20–55% of patients with a diagnosis...

...Gerhard E. Feurle; Verena Moos; Thomas Schneider; Florence Fenollar; Didier Raoult Sir, Whipple's disease is a chronic infection caused by Tropheryma whipplei. In a prospective study, the CNS was found to be involved in 38.5% of the cases. ¹ Treatment is not always successful...

... with oral trimethoprim/sulfamethoxazole (160 mg/800 mg) twice daily for 1–2 years, ^{8 , 9} has been considered. Thanks to advances in Tropheryma whipplei culture (T. whipplei is the causative bacterium of WD), ¹⁰ full genome sequencing ^{11 , 12}...

... doxycycline hydroxychloroquine drug combinations Tropheryma whipplei Sir, We agree with many of the points made by Bakkali et al. ¹ in their letter responding to our paper ‘Therapy for Whipple’s disease’ published in JAC last year. ² References 1...

...–sulfamethoxazole Am J Gastroenterol 2000 95 2390 1 4 Cannon R Whipple's disease, genomics, and drug therapy Lancet 2003 361 1916 5 Boulos A Rolain JM Mallet MN Molecular evaluation of antibiotic susceptibility of Tropheryma whipplei in axenic medium J...

... 2003 361 1916 9 Boulos A Rolain JM Mallet MN Molecular evaluation of antibiotic susceptibility of Tropheryma whipplei in axenic medium J Antimicrob Chemother 2005 55 178 81 10 Boulos A Rolain JM Raoult D Antibiotic susceptibility...

..., Tropheryma whipplei, has been cultured only rarely. By using a polyclonal rabbit antibody produced against a cultured strain of T whipplei, tissue sections from 18 patients with Whipple disease were studied. Specimens from patients with histologic mimics and other infections served as control...

.../9780192870414.003.0011 Whipple’s disease (WD) of the brain is an extraordinary infectious disease caused by the bacillus Tropheryma whipplei. WD is difficult to diagnose and may lead to disability and death if unrecognized. Central nervous system involvement may occur secondary to gastrointestinal...

...Oxford University Press Whipple’s disease is an uncommon infection caused by the actinomycete Tropheryma whipplei, most commonly diagnosed when overt small intestinal disease leads to malabsorption, but with protean other clinical manifestations (e.g. systemic, neurological...

...Oxford University Press Whipple disease (WD) is a multisystemic infection caused by the bacillus Tropheryma whipplei. Although the organism is ubiquitous in the environment, WD is rare. In affected individuals, the organism resides intracellularly within macrophages and can manipulate host immune...

..., followed by 1 year of maintenance therapy with trimethoprim-sulfamethoxazole. arthralgia trimethoprim-sulfamethoxazole Tropheryma whipplei weight loss Whipple disease Tropheryma whipplei Whipple disease WD antibiotics tetracyclines ceftriaxone immune reconstitution syndrome...