... to influence the pathway, for therapeutic purpose. It reveals the various unexplored FZD-WNT combinations that have been untested till now in the Wnt pathway. Wnt pathway sensitivity analysis support vector ranking combinatorial search forest Sobol indices Hilbert–Schmidt Independence Criterion indices...

.... This innovative method still needs to be more widely validated but already gives interesting avenues to improve the calibration of FSPMs. Global sensitivity analysis Sobol indices winter oilseed rape functional–structural plant model generalized least squares parameter estimation model calibration Akaike...

... collocation, polynomial chaos, Sobol indices and Gaussian processes. The chapter outlines standard procedures for verification and validation, emphasizing their critical role in ensuring the accuracy and reliability of simulations. It describes techniques for uncertainty quantification specific to molecular...