..., Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Treatment options for recurrent/refractory CNS lymphoma are limited but the Bruton’s tyrosine kinase inhibitor ibrutinib has shown promise.. To increase efficacy and reduce...

... is a sanctuary for residual cancer cells, some have advocated for the addition of intraventricular chemotherapy to the systemic regimen for managing CNS lymphoma as well. ^{19 , 20} Specifically, multiagent intraventricular chemotherapy (MAIVC), delivered through an intracranial CSF reservoir, has been...

... Polychemotherapy based on high-dose methotrexate (HD-MTX) is the standard therapy for newly diagnosed younger patients (<65 years) with primary CNS lymphoma (PCNSL). In the modified Bonn protocol, consolidation therapy consists of intraventricular chemotherapy that is added to the continuation of HD-MTX-based...

...-reuse-rights ) Abstract Background Accurate intraoperative diagnosis is crucial for differentiating between primary central nervous system (CNS) lymphoma (PCNSL) and other CNS entities, guiding surgical decision-making, but represents significant challenges due to overlapping histomorphological...

... This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Epstein-Barr virus (EBV)⁺ and EBV^- primary CNS lymphomas (PCNSL) carry...

.... Graphical Abstract Graphical Abstract primary CNS lymphoma consolidation etoposide cytarabine The median follow-up period was 23 (range: 3-87) months for all 51 patients who received EA consolidation. Of the 51 patients, 6 (11.7%) were alive with disease-free status, 4 (7.8%) died due to treatment...

..., provided the original work is properly cited. For commercial re-use, please contact [email protected] Anniversary fund of the Austrian National Bank 16725 TAI98-B Vienna Science and Technology Fund 10.13039/501100001821 LS20-034 LS20-065 Key Points In primary CNS lymphoma...

... guide future treatment approaches. circulating tumor DNA CNS lymphoma composite biomarker improved early outcome prediction MRI-based 3D volumetry Deutsche Forschungsgemeinschaft 10.13039/501100001659 Importance of the Study The outcome of CNS lymphomas is highly heterogeneous. The IPCG response...

... General Hospital. We searched our institutional database for patients with active CNS lymphoma treated with CD19-directed CAR T-cells between 2018 and 2022. Patients were selected based on the following criteria: (1) presence of active CNS lymphoma confirmed by neuroimaging or cerebrospinal fluid (CSF...

... in the US annually. ¹ A small subset of DLBCL cases arise within and are restricted to the central nervous system. These are termed primary CNS lymphoma (PCL), which has an annual incidence of 1400 cases in the US ² and accounts for 3% of all primary CNS tumors. ³...

... on metabolic markers in CSF that can effectively predict PCNSL patient prognosis before the HD-MTX-based chemotherapy treatments. high-dose methotrexate metabolomics prediction model primary CNS lymphoma National Key R&D Program of China 10.13039/501100012166 2020YFA0803800 2019YFA0801900...

...Alipi V Bonm; Anthony Menghini; Caroline E Drolet; Jerome J Graber Abstract Background Most patients with primary CNS lymphoma (PCNSL) achieve durable remission whereas a minority die in the first year. Sarcopenia is a powerful predictor of mortality in the brain and systemic cancers. Temporalis...

... or for elderly patients with relapsing intraocular disease (Good Practice Point). ^{39 , 40} Patients with concurrent intraocular and CNS lymphoma should be treated no differently from other patients with PCNSL (Good Practice Point). If consolidation WBRT is proposed, it should include both...

... lymphoma. primary CNS lymphoma recurrent CNS lymphoma chemotherapy radiotherapy salvage therapy Key Points There is no consensus for standard of care for salvage therapy for PCNSL. Using radiotherapy with rituximab and temozolomide as salvage therapy is effective. Salvage therapy...

..., ALK+), are extremely rare, with only case reports and a single small case series currently published in the literature. ^3-32 Key Points Primary central nervous system anaplastic large cell lymphoma, anaplastic lymphoma kinase positive (CNS ALCL, ALK+) is a rare CNS lymphoma...

.../chorus/standard_publication_model ) Abstract Background This study analyzes sociodemographic barriers for primary CNS lymphoma (PCNSL) treatment and outcomes at a public safety-net hospital versus a private tertiary academic institution. We hypothesized that these barriers would lead to access...

... and refractory (r/r) primary CNS lymphoma (PCNSL) is poor, and the development of new therapeutic agents is desirable. Comprehensive genetic analysis of PCNSL has shown that MYD88 and CD79B are frequently mutated and are oncogenic drivers, suggesting that Bruton’s tyrosine kinase (BTK), which is located...

.... Considering the residual radiation necrosis, whole-brain irradiation was avoided. Moreover, consolidation therapy was performed only with high-dose cytarabine therapy. primary CNS lymphoma stereotactic radiosurgery delayed diagnosis Abstracts PCNSL (ML) 3Department of Neurosurgery, Kyorin University...

...Yasuo Sugita; Go Hashimoto; Kenji Fukuda; Kenji Takahashi; Taro Shioga; Takuya Furuta; Fumiko Arakawa; Koichi Ohshima; Hideo Nakamura; Hajime Miyata; Masashi Watanabe; Akiyoshi Kakita Marginal zone B-cell lymphoma Mucosa-associated lymphoid tissue Primary CNS lymphoma Collaborative Research...

..., provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Background In patients with presumed primary CNS lymphoma (PCNSL), a systemic manifestation is found only in a small minority. Although bone marrow biopsy (BMB) is recommended...