... DeAngelis; Anne S Reiner; Katherine S Panageas; Jasmine H Francis; Ingo K Mellinghoff; Christian Grommes Abstract Background Treatment options for recurrent/refractory CNS lymphoma are limited but the Bruton’s tyrosine kinase inhibitor ibrutinib has shown promise.. To increase efficacy and reduce...

... in modulating these processes, particularly in CNS. While our understanding of TERRAs largely stems from cancer research, their involvement in these physiologic and pathologic pathways highlights their potential as therapeutic targets for CNS disorders as well. noncoding RNA telomere CNS dysfunction...

...; David A Wheeler; Jason Chiang Figure 3. Histologic spectrum of CNS NB-FOXR2. (A–C) The characteristic embryonal-looking areas of CNS NB-FOXR2 showed substantial variation. Areas resembling high-grade glioma may be found (D). Diffusely infiltrating tumor cells may masquerade as a glial neoplasm (E...

... [email protected]. 2025 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Pediatric high-grade central nervous system (pHG-CNS) tumors...

... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Relapsed/refractory pediatric CNS tumors have a poor prognosis. EGFR is commonly overexpressed, but EGFRvIII mutations...

...-modified neural progenitor cells to explore dysregulation of mRNA translation in TSC, and find that targeting mTORC1 and MNK1/2 signalling may help reverse neurodevelopmental abnormalities. 4E-BP1 S6K1 protein synthesis 5’UTR rapalogs CNS ACCEPTED MANUSCRIPT 1 TSC2 loss in neural progenitor cells...

... with response to multi-agent intraventricular chemotherapy in patients with CNS lymphoma Aastha Aastha1,2, Hannah Wilding3, Nicholas Mikolajewicz4,5, Shahbaz Khan2, Vladimir Ignatchenko2, Leonardo Jose Monteiro De Macedo Filho3, Debarati Bhanja3, Gabriela Remite-Berthet3, Madison Heebner3, Michael Glantz6...

... NI4OS-National Initiatives for Open Science in Europe is funded by the European Commission's Horizon 2020 program. Study EEG by using EEGBUB.GE is aimed to determine the EEG pattern to hyperventilation based on time of onset EEG and age of patients with different CNS disorders. The first online EEG...

... harbours disulphated disaccharide units on carbons 4 and 6 of galactosamine. Upon trauma in the CNS, CSPG expression is upregulated to form a glial scar promoting inflammation and inhibiting regeneration. ^2-4 Regarding regeneration, CSPGs act on neurons and oligodendrocytes (OLs) to block...

...-reuse-rights ) Abstract Background Non-malignant tumors of the CNS contribute substantially to the morbidity and mortality from CNS tumors. It is critical to understand the epidemiology of non-malignant CNS tumors separately from CNS malignancies to inform resource allocation and policy since...

... Polychemotherapy based on high-dose methotrexate (HD-MTX) is the standard therapy for newly diagnosed younger patients (<65 years) with primary CNS lymphoma (PCNSL). In the modified Bonn protocol, consolidation therapy consists of intraventricular chemotherapy that is added to the continuation of HD-MTX-based...

... Wesseling Table 1. WHO CNS5 Tumor Types That Correspond to Methylation Classes ^* , With Their Relationships Identified Site CNS WHO category CNS WHO family CNS WHO tumor type Methylation class(es) Gliomas, glioneuronal tumors, and neuronal tumors Gliomas, glioneuronal...

...-reuse-rights ) Abstract Background Accurate intraoperative diagnosis is crucial for differentiating between primary central nervous system (CNS) lymphoma (PCNSL) and other CNS entities, guiding surgical decision-making, but represents significant challenges due to overlapping histomorphological...

...Sean O’Leary; W Elorm Yevudza; Peace Odiase; Muhammad Ammar Haider; Takara Newsome-Cuby; Odesanya Okikioluwa; Kwadwo Darko; Hannah Weiss; Umaru Barrie; Mabel Banson; Teddy Totimeh Table 1. Cumulative Frequency of 12 552 CNS and Non-CNS Metastatic Tumor Patients Stratified by Country in the 28...

... This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background Epstein-Barr virus (EBV)⁺ and EBV^- primary CNS lymphomas (PCNSL) carry...

... and the upcoming SNO 2024 Annual meeting in Houston, TX. brain tumors CNS tumor registry global neurosurgery molecular subtyping sub-Saharan Africa Key Points Addressing Diagnostic and Treatment Gaps: The BTCA seeks to tackle significant gaps in CNS tumor diagnostics and treatment across Africa...

... in clinical trials in an attempt to improve outcomes of CNS ischemic events, the finding by Yi et al that HCELL+ MSCs attenuate stroke injury lends further support to the findings of others ⁴ indicating that the intravascular administration of HCELL+ MSCs mitigates ischemia-reperfusion injury...

... University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background In the POLA cohort, 3 pathological groups of CNS WHO grade 3 oligodendroglioma IDH-mutant and 1p/19q co-deleted have been described: group 1 (high mitotic count...

...%) 0 (0%) 269 (12.1%) 0 (0%) 413 (11.8%) Other 0 (0%) 281 (21.9%) 0 (0%) 613 (27.7%) 0 (0%) 894 (25.5%) At diagnosis 0 (0%) 267 (20.8%) 0 (0%) 878 (39.6%) 0 (0%) 1145 (32.7%) CNS tumor subtype 3.1 Astrocytoma 1501 (53.7%) 593 (46.1%) 1980 (52.0%) 1165 (52.5%) 3481 (52.7...

... conventional methods entirely. Tailoring diagnostic panels to regional pathogen prevalence is recommended to enhance diagnostic accuracy and clinical outcomes in low- and middle-income countries. cerebrospinal fluid (CSF) CNS infections diagnostics FAME Vietnam PAN-ASEAN Coalition for Epidemic and Outbreak...