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Araceli Rosa, Lourdes Fañanás, Jim van Os, Tracy Ribchester, Nadia Davies, Bárbara Arias, Alison McDonald, Robin M. Murray, Further Evidence That Congenital Dermatoglyphic Abnormalities Are Associated With Psychosis: A Twin Study, Schizophrenia Bulletin, Volume 28, Issue 4, 2002, Pages 697–701, https://doi.org/10.1093/oxfordjournals.schbul.a006973
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Abstract
The presence of abnormal palmar flexion creases (APFC) and dermatoglyphic ridge dissociation (RD) may constitute enduring evidence of a prenatal insult that occurred before the third trimester of intrauterine life. We examined these dermatoglyphic abnormalities in a twin study of psychotic disorders. RD and APFC were analyzed in a monozygotic (MZ) twin sample from the Maudsley Hospital in London (11 normal control pairs, 16 pairs concordant for psychosis, 9 pairs discordant for psychosis, 1 concordant triplet, and 1 triplet with one affected member). The risk of either RD or APFC was 44 percent in affected twins and 20 percent in nonaffected twins (odds ratio = 3.25, 95% confidence interval: 1.03–10.31; one-sided p = 0.023). In the group of MZ twins discordant for psychosis, discordance for RD or APFC always paralleled discordance for psychosis (one-sided p = 0.078), suggesting the operation of nongenetic factors. The results confirm previous work suggesting the possibility that nongenetic factors early in pregnancy contribute to the liability to develop psychosis in later life.