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ALBERT A. C. YEUNG LAIWAH, ROBERT MACTIER, KENNETH E. L. McCOLL, MICHAEL R. MOORE, ABRAHAM GOLDBERG, Early-Onset Chronic Renal Failure as a Complication of Acute Intermittent Porphyria, QJM: An International Journal of Medicine, Volume 52, Issue 1, WINTER 1983, Pages 92–98, https://doi.org/10.1093/oxfordjournals.qjmed.a067745
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Abstract
In a retrospective survey of patients who have had a proven attack of acute intermittent porphyria (AIP) in the West of Scotland a highly significant association (p < 0·001) was observed between AIP and the development of early-onset chronic renal failure. Six patients with AIP and chronic renal failure arising in early middle-age are described. As no other cause could be attributed to the renal failure three possible causal links between these two conditions were considered, namely, enhanced susceptibility to analgesic nephropathy, porphyria-induced hypertension, and nephrotoxic effects of porphyrins and their precursors. We suggest that porphyria-induced hypertension is the most important factor in causing early-onset chronic renal failure in acute intermittent porphyria