The Quarterly Journal of Medicine (QJM) has been at the forefront of highlighting significant societal mental health issues in a COVID-19 world.1–10 We continue to contribute to the expanding literature on this important subject and Wellcome the paper by Dr. Li and colleagues from Soochow University, China on identifying factors associated with enhanced societal vulnerability to depression in a world coming to terms with living with COVID-19.

It is well recognized historically that major economic upheaval or natural disasters are often accompanied by an enhanced societal vulnerability to significant mental health problems including depression, anxiety, post-traumatic stress disorder, substance abuse and suicide. In the context of living with COVID, the authors recruited just over 2000 residents and found an overall prevalence of clinically significant depression of 27%. Factors associated with vulnerability to depression included rural younger females, higher body mass index within a lower socioeconomic group. We recommend this article to our readers.

Cystic fibrosis and diabetes

Cystic fibrosis (CF) is the most common life-threatening inherited condition in the Caucasian population. CF life expectancy has improved dramatically over recent years. The recent development of disease-modifying CFTR modulator therapies is predicted to further improve life expectancy in the near future.

However, such increased life expectancy brings new challenges related to the complications of a chronic disease. One of the most important extra-pulmonary complications of CF is CF-related diabetes, which affects over 50% of adult CF patients. We therefore felt it timely to commission a state-of-the-art review on this important subject. Dr. Frost and colleagues from the University of Liverpool provide a comprehensive review, published in the current issue of the Journal, on the underlying mechanisms, investigation and management of CF-related diabetes.

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