https://orcid.org/0000-0003-2447-6161
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Yunqing Yu, Prohibitin Shuttles Between Mitochondria and the Nucleus to Control Genome Stability During the Cell Cycle, Plant Physiology, Volume 179, Issue 4, April 2019, Pages 1435–1436, https://doi.org/10.1104/pp.19.00176
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The prohibitin (PHB) protein family is highly conserved from prokaryotes to eukaryotes (Van Aken et al., 2010). Initially identified as a tumor suppressor in rat liver, PHBs in animals are localized in various cell compartments, including mitochondria, nuclei, and plasma membranes, and function as scaffold proteins in many signaling pathways, including those underlying cell proliferation, apoptosis, aging, mitochondrial biogenesis, and immune response. Thus, PHBs have often been targeted for drug discovery and clinical applications (Thuaud et al., 2013). Plants may have multiple PHBs due to genome duplication. Five PHB genes (PHB1, PHB2, PHB3, PHB4, and PHB6) are expressed in Arabidopsis (Arabidopsis thaliana), and have similar expression patterns in the mitochondria of shoot and root meristematic tissues (Van Aken et al., 2007). Loss of function of PHB3 results in mitochondrial swelling, reactive oxygen species (ROS) accumulation, inhibition of cell division in the meristem, and growth retardation, demonstrating that PHB functions in mitochondria and in cell division through mitochondrial-generated ROS signaling (Van Aken et al., 2007; Kong et al., 2018).
