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Malka Aker, Shirly Ohanona, Shira Fisher, Efrat Katsman, Shirit Dvorkin, Efrat Kopelowitz, Moshe Goldstein, Zohar Barnett-Itzhaki, Moshe Amitay, CDB—a database for protein heterodimeric complexes, Protein Engineering, Design and Selection, Volume 31, Issue 10, October 2018, Pages 361–365, https://doi.org/10.1093/protein/gzy030
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Abstract
Crystallographic structures of protein complexes are essential to develop proteomic and structural biology methods, as prediction of protein–protein interaction (PPI) sites and protein–protein docking. Such structures can aid the development of protein complexation inhibitors. Complex DataBase (CDB), accessible at www.jct-bioinfo.com/cdb/search, is a database web application for heterodimeric protein crystallographic complexes along with the crystallographic structures of each individual unbound protein. Direct access to crystallographic structures of protein complexes, along with provided annotations, can serve as starting point for constructing new experimental protein complexes sets of any type, for protein binding studies, and the development and evaluation of PPIs prediction methods.