Abstract

Background

Lower respiratory infections (LRIs) cause substantial mortality and morbidity in the United states of America (USA) accounting for 2.78% of all causes of deaths. However, there is a large statewide variation within the United States with regard to LRIs burden. Comparable and consistent state-level measures of total LRIs burden have not been produced previously.

Methods

We used Global Burden of Disease Methodology to estimate the burden of LRIs by Age-groups, year, sex, location across the USA.

Results

In 2019, there were 299,564(95% UI 281,732–317,390) prevalent cases of LRIs in the USA, with an age-standardized rate (ASR) of 85.2 (95% UI 78.8-91.9) per 100,000 population. The annual percentage change of total number incidence increased by 14% followed by deaths increased 13% from 1990-2019. Furthermore, Mississippi [20.49 (95% UI 17.4–23.9)] per 100,000 and Tennessee [19.1 (95% UI 16–22.5)]per 100,000 had the highest age-standardized mortality rate (ASMR) in 2019. In 2019, the incidence and DALY were highest in the 60-64 age group,75-79 age group respectively in both females and males.

Age-Standardized Incidence, Mortality and DALYs Lower Respiratory Tract Infection in United States, 2019
Trend of Lower Respiratory Tract Infection in USA from 1990-2019

A) All age-counts, Incidence, Death, DALY B) Age-standardized rate Incidence, Death, DALY

Sex-wise distribution of Lower Respiratory Tract Infection, Deaths, per 100,000 across the United States
Conclusion

LRIs continue to be a significant burden on the healthcare system in the United States, causing a significant economic impact and affecting vulnerable populations disproportionately. Preventive measures and prompt treatment can help reduce this burden and improve the overall health of the population.

Disclosures

All Authors: No reported disclosures

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Author notes

Session: 242. Respiratory Infections - Bacterial

Saturday, October 14, 2023: 12:15 PM

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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