
Contents
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Depo-Provera and Contraceptive Risk Depo-Provera and Contraceptive Risk
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Three Stories of Contraceptive Risk Three Stories of Contraceptive Risk
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Judith Weisz’s Story Judith Weisz’s Story
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Anne Macmurdo’s Story Anne Macmurdo’s Story
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Roger Gauntlett’s Story Roger Gauntlett’s Story
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A Common Thread of Contraceptive Drug Risk A Common Thread of Contraceptive Drug Risk
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Federal Drug Law Federal Drug Law
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State Civil Law State Civil Law
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State Criminal Law State Criminal Law
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Contraceptive Drug Policy Environment Contraceptive Drug Policy Environment
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A Collective Story A Collective Story
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Introduction: The Odyssey of Depo-Provera
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Published:May 2017
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Extract
The Pill, the IUD, and Norplant have dominated public awareness and debate over contraceptive technologies. Depo-Provera, a three-month injectable drug, held out the promise that it could also play a leading role in the contraceptive revolution, but it has not received much more than episodic public attention.1Close Still, the drug has raised difficult questions about its experimental, contraceptive, and criminal justice uses. After the FDA approved The Upjohn Company’s application to test Depo-Provera as a female contraceptive in 1963, the drug was administered to 11,400 women at the Grady Memorial Hospital’s Family Planning Clinic in Atlanta, the drug’s major domestic clinical trial. The drug was also administered to convicted male sex offenders at the Johns Hopkins Hospital in Baltimore, but without the FDA’s experimental authorization. Neither at Grady nor at Johns Hopkins did the men and women involved in these studies give their informed consent. Depo-Provera’s approval for other medical purposes as early as 1960 meant that for thirty-two years prior to its FDA contraceptive approval in 1992, physicians were able to prescribe the drug as a contraceptive and state trial court judges were able to impose it as a probation condition for sex offenders. Depo-Provera’s FDA contraceptive approval has made little difference in the drug’s contraceptive and criminal justice uses. Physician prescribing practices and judicial use of the drug continue to raise serious ethical and legal issues. Female patients and male defendants are still injected with the drug without being informed of Depo-Provera’s short-and long-term side effects.
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