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Satoshi Hama, Mitsuhiro Akiyama, Misako Higashida-Konishi, Tatsuhiro Oshige, Hiroshi Takei, Keisuke Izumi, Hisaji Oshima, Yutaka Okano, Successful treatment with tofacitinib for relapse of rapidly progressive interstitial lung disease in anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis, Modern Rheumatology Case Reports, Volume 7, Issue 1, January 2023, Pages 92–95, https://doi.org/10.1093/mrcr/rxac049
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ABSTRACT
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is associated with clinically amyopathic dermatomyositis (CADM) with rapidly progressive interstitial lung disease (RP-ILD). Recently, several studies have reported that tofacitinib (TOF), a Janus kinase inhibitor, might be effective for cases of new or refractory RP-ILD in anti-MDA5 antibody-positive CADM; however, it is unknown whether TOF can also be effective for relapsed cases. We herein report a relapsed case of RP-ILD in anti-MDA5 antibody-positive CADM, which was successfully treated by combination therapy with TOF (5 mg twice daily). Our case suggests that TOF may also be a potential treatment option for relapsed cases of this disease.