https://orcid.org/0000-0002-6951-8575
-
Views
-
Cite
Cite
Kyosuke Hattori, Nobunori Takahashi, Toshihisa Kojima, Shiro Imagama, Predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis treated with denosumab, Modern Rheumatology, Volume 33, Issue 1, January 2023, Pages 217–223, https://doi.org/10.1093/mr/roab129
Close - Share Icon Share
ABSTRACT
To investigate efficacy of long-term treatment with denosumab and predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis (PMO).
We enrolled 111 PMO patients who had T-scores ≤−2.5 either at the lumbar spine (L-) or femoral neck (FN-), who had never been treated for osteoporosis, and who could be followed for at least 3 years. We first evaluated changes in bone mineral density (BMD) for up to 7 years. We next defined the treatment goal as the achievement of a T-score >−2.5 at month 36 and performed multivariate analysis to identify predictive factors for achievement of the goal.
Lumbar spine- and femoral neck bone-mineral density increased yearly for 7 years. Among 87 patients with baseline L-T-scores ≤−2.5, better baseline L-T-scores predicted achievement of L-T-scores >−2.5 at month 36. The cut-off value for baseline L-T-score was −3.4. Among 76 patients with baseline FN-T-scores ≤−2.5, better baseline FN-T-scores predicted achievement of FN-T-scores >−2.5 at month 36. The cut-off value for baseline FN-T-scores was −2.8.
Long-term treatment with denosumab was effective in PMO patients. As better baseline T-score predicted achievement of T-scores >−2.5, early initiation of treatment will contribute to better outcome.
