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Kenneth Alonso, Nicholas Brownlee, Changes in Serum Values as a Result of Prolonged Clot Contact: Comparison of Sodium lodoacetate and Barrier-Activated Integrated Serum Separator Tubes in Maintaining Specimen Integrity, Laboratory Medicine, Volume 11, Issue 8, 1 August 1980, Pages 548–552, https://doi.org/10.1093/labmed/11.8.548
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Abstract
Changes in serum biochemical values as a function of clot contact time were investigated. Changes that occurred up to 24 hours after blood collection were studied by drawing three sets of blood specimens from 11 subjects. A barrieractivated integrated serum separator tube and a tube containing sodium iodoacetate were compared on the basis of their effectiveness in maintaining specimen integrity. Plain tubes were used as a reference. Minor but clinically significant elevations of serum values for alanine aminotransferase (ALT or SGPT) and potassium were seen at 24 hours after specimen collection in sodium iodoacetate tubes. Sodium iodoacetate tubes are the collection tubes most likely to maintain specimen integrity when confronted with suboptimal specimen handling; however, they are not a replacement for prompt centrifugation and separation of clotted blood specimens.