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Leora R Feldstein, Jasmine Ruffin, Ryan Wiegand, Lauren Grant, Tara M Babu, Melissa Briggs-Hagen, Jefferey L Burgess, Alberto J Caban-Martinez, Helen Y Chu, Katherine D Ellingson, Janet A Englund, Kurt T Hegmann, Zuha Jeddy, Jennifer Kuntz, Adam S Lauring, Karen Lutrick, Emily T Martin, Clare Mathenge, Jennifer Meece, Claire M Midgley, Arnold S Monto, Allison L Naleway, Gabriella Newes-Adeyi, Leah Odame-Bamfo, Lauren E W Olsho, Andrew L Phillips, Ramona P Rai, Sharon Saydah, Ning Smith, Harmony Tyner, Molly Vaughan, Ana A Weil, Sarang K Yoon, Amadea Britton, Manjusha Gaglani, Protection From COVID-19 Vaccination and Prior SARS-CoV-2 Infection Among Children Aged 6 Months–4 Years, United States, September 2022–April 2023, Journal of the Pediatric Infectious Diseases Society, Volume 14, Issue 1, January 2025, piae121, https://doi.org/10.1093/jpids/piae121
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Abstract
To understand how coronavirus disease 2019 vaccines impact infection risk in children <5 years, we assessed risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from September 2022 to April 2023 in 3 cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in naïve young children.