... through the glucocorticoid receptor and histone deacetylase 4, consequently leading to decreased CDCA levels. In summary, our findings suggest that intrauterine low-expression programming of CYP7B1, induced by elevated glucocorticoid levels, reduces local CDCA levels in the cartilage of PCE offspring...

.... We overcome these shortcomings and develop a computationally efficient mixed-integer programming framework for learning medium-sized problems that accounts for arbitrary heteroscedastic noise. We present an early stopping criterion under which we can terminate the branch-and-bound procedure...

... of VoI should reflect the specific forest planning goals and allow for the inclusion of multiple objectives. We present a method that quantifies multi-objective VoI using stochastic programming optimization, enabling the integration of data uncertainty into the planning process. The developed...

... networks constraint-based modeling computational strain design metabolic engineering robustness and fragility mixed-integer linear programming Abstract Minimal cut sets (MCSs) have emerged as an important branch of constraint-based metabolic modeling, offering a versatile framework for analyzing...

.... Properties of such loss measures are studied and a pragmatic knowledge engineering tool is proposed for computing loss measures using a well-known probabilistic logic programming language ProbLog. This paper includes a working methodology for studying and determining the strength of different...

... programming Evaluating player performances in soccer has attracted a lot of interest in the last decade. Due to the low-scoring and complex nature of the sport, accurately measuring a player’s contribution to the game is a challenging task. However, evaluating individual performances in team sports...

... development. Heat stress is one of the most common stressors experienced by mammals, and recent evidence suggests a role in the programming of the dam and fetus. This review explores different hypotheses of fetal programming, including the Barker hypothesis, which connects early-life malnutrition to metabolic...

... These two authors contributed equally to this work. Graphical Abstract Figure. Image-based quantification of Candida albicans germination and filamentation using the open-source visual programming language...

... (E₂) negative and positive feedback responsiveness in adulthood. Heifers were selected from a larger population programmed nutritionally using a 3 × 2 factorial arrangement of pre- and postnatal diets. Beginning at 90 d of pregnancy, Bos indicus-influenced cows (n = 95) bearing...

..., and steroidogenesis. These results indicate potential for long-term implications via reduced offspring reproductive potential in horses. fetal programming foal horse overnutrition testes Fetal programming describes how environmental factors during fetal development play a role in offspring health and production...

.../malabz/FORAlign . sequence alignment four Russians speedup dynamic programming parallel algorithm design Xidian University 10.13039/501100005320 TZJH2024027 National Natural Science Foundation of China 10.13039/501100001809 62472344 62452107 62072353 62272065 Multiple sequence...

... variant of the proposed method gives state-of-the-art results in the Turing benchmark for unsupervised changepoint detection. piecewise regression fast algorithm penalized least squares non-convex optimization model selection dynamic programming signal estimation signal processing Assume we...

... was 35 years (IQR, 28–47) at the time of initiation, and 90% identified as Black, 28% as cisgender women, and 8% as transgender women. The median CD4 count and percentage were 494 cells/mm³ (IQR, 282–753) and 28% (IQR, 19%–37%). Table 1 summarizes HBV status upon initiation, program...

... de Feveri; Sabine A S Langie; Roger Godschalk; Vanessa Moraes de Andrade Corresponding author. Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, Department of Health Sciences, University of Southern Santa Catarina, UNESC, 1105, Universitária Rd, 88806000, Criciúma, Santa...

... ). Nevertheless, limited knowledge exists regarding different sources of trace minerals for late-gestating beef cows and their impacts on offspring productivity. beef cows fetal programming hydroxychloride organic-complexed sulfate trace minerals Lay Summary Trace minerals like Zn, Cu, and Mn play...

... design of 3 mutually exclusive indices: (1) foundational interoperability technologies and practices (the Core Index); (2) the adoption of novel interoperability technologies, including practices relevant to engaging patients, the use of application programming interfaces (APIs), and information exchange...

... validate the model’s and algorithm’s efficacy, confirming their applicability in real-world scenarios. heavy-duty railway maintenance machinery location-routing programming location evaluation index game theory National Natural Science Foundation of China 10.13039/501100001809 U1734208 National...

...-birth-weight piglets from large litters. circadian rhythm fetal programming gene expression growth and development melatonin pregnancy skeletal muscle swine National Institute of Food and Agriculture 10.13039/100005825 1024664 U.S. Department of Agriculture 10.13039/100000199 1024664...

..., there were no differences in liver metabolism. The differences in muscle fiber measurements and alterations in muscle metabolism indicate the potential for altered growth of offspring from immune stimulated dams. fetal programming immune challenge lipopolysaccharide metabolomics skeletal muscle...

... Programming, which can be easily verified by using standard numerical software. Finally, several numerical examples are included to illustrate the validity and the effectiveness of the developed results. 2D systems stabilization positive systems positive control positive Roesser model linear programming...