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Ellen T. Chang, Maria Hedelin, Hans-Olov Adami, Henrik Grönberg, Katarina A. Bälter, Re: Zinc Supplement Use and Risk of Prostate Cancer, JNCI: Journal of the National Cancer Institute, Volume 96, Issue 14, 21 July 2004, Page 1108, https://doi.org/10.1093/jnci/djh206
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Leitzmann et al. ( 1 ) recently reported that men who consumed more than 100 mg/day of supplemental zinc or who took supplemental zinc for at least 10 years had an approximately twofold-elevated risk of advanced prostate cancer compared with nonusers. Given these provocative findings, we investigated the relationship between zinc supplement use and the risk of prostate cancer in a recently completed population-based case-control study in Sweden that included 1499 prostate cancer case patients and 1130 control subjects. After granting informed consent, participants completed a questionnaire that assessed possible risk factors for prostate cancer, including supplemental zinc intake. Frequency of intake was recorded as the number of tablets consumed per week and the number of months per year tablets were used; duration of use was recorded as total number of years. This study was approved by the Karolinska Institute and Umeå University Ethics Committees and was funded by the Swedish Cancer Society.