Volume 49, Issue 2, February 2019

In the AJCC eighth edition, bone and soft tissue sarcomas are described according to primary tumor site for the first time. The differences from the previous edition are discussed.

This review summarized evidence to interpret the results of ongoing clinical trials based on the genetic background and develop individual optimal treatments with molecular-targeted drugs for endometrial cancer.

In this Phase II study, no dose–response relationship was observed after oral netupitant administration (30, 100 or 300 mg) in Japanese patients receiving highly emetogenic chemotherapy.

A cohort study to assess LDCT screening for lung cancer targeting the general population demonstrated a reduction in lung cancer mortality and estimated the proportion of overdiagnosis.

The analysis from international surveys showed current trends about the criteria for optimal cytoreduction, the extent of aggressive surgery and the preference of neoadjuvant chemotherapy for advanced ovarian cancer.

Retrospective analysis of locally advanced cervical carcinoma patients treated with chemoradiation using 3DCRT and concurrent cisplatin chemotherapy resulted in comparable survival outcomes, acute and late toxicities as with IMRT.

None of the 15 patients with adult T-cell leukaemia/lymphoma developed Grade ≥3 radiation-induced dermatitis during a total of 46 courses of moderate-dose radiotherapy after the administration of mogamulizumab.

Radiotherapy may function as a powerful initiator for immunotherapy. We performed a study of stereotactic radiation therapy plus nivolumab. This combination therapy was well tolerated.

Of 110 lung cancer patients who received nab-PTX, nine developed interstitial lung disease and six died. Preexisting interstitial pneumonia was associated with higher rates of nab-PTX-associated interstitial lung disease.

For furthering precision medicine in Japan, we present our multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan between June 2016 and October 2017.

The loss of psoas major muscle volume was an independent risk factor of poor prognosis in testicular cancer patients undergoing systematic chemotherapy.

A multicenter, randomized, controlled trial has begun to compare neoadjuvant chemotherapy using gemcitabine and S-1 with upfront surgery for patients planned resection of pancreatic cancer in January 2013.

AL amyloidosis patients with concurrent multiple myeloma (MM) exhibited lower prevalence of t(11;14) than those without MM.