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Natsuki Matsunaga, Masao Asai, A Case of Huge Myoepithelial Carcinoma of the Submandibular Gland, Japanese Journal of Clinical Oncology, Volume 40, Issue 10, October 2010, Page 995, https://doi.org/10.1093/jjco/hyq174
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A 48-year-old woman suffering from dysphagia and swelling of the neck for 4 years was referred to our hospital. Computed tomography scan demonstrated a huge tumor (14 × 9 cm in size) around the lower jaw, which was enhanced heterogeneously and accompanied with partial calcification. On magnetic resonance imaging, the tumor occupied the parapharyngeal space, extending from the level of the parotid gland to the upper margin of the sternum, and adjacent to the left side of the nasopharynx (Fig. 1, sagittal image; Fig. 2, axial image). The biopsy of the tumor revealed a myoepithelial carcinoma, and tumor resection with left submandibular gland, skin ablation and bilateral supraomohyoid neck dissections were performed. Free antero-lateral thigh flap transplantation was conducted to cover the tissue defect.
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Pathologically, the tumor proved to be myoepithelial carcinoma arising from the submandibular gland (Fig. 3, resected specimen; Fig. 4, hematoxylin eosin stain, ×200; note that color versions of both these figures are available as supplementary data at http://www.jjco.oxfordjournals.org). The tumor involved the skin of the neck, but there was neither direct invasion to the surrounding laryngopharyngeal organs nor lymph node metastasis, and surgical margins were negative. The patient is alive without recurrence 17 months after the operation.
