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Takeshi Yoshikawa, Kayo Nakanishi, Tsutomu Maruta, Daisuke Takenaka, Shozo Hirota, Shinichi Matsumoto, Katsuyasu Saigo, Yoshiharu Ohno, Masahiko Fujii, Kazuro Sugimura, Anticoagulant-Induced Pseudothrombocytopenia Occurring after Transcatheter Arterial Embolization for Hepatocellular Carcinoma, Japanese Journal of Clinical Oncology, Volume 36, Issue 8, August 2006, Pages 527–531, https://doi.org/10.1093/jjco/hyl054
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Abstract
Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.