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Madhup Rastogi, Madhu Srivastava, Kundan S. Chufal, M. C. Pant, Kirti Srivastava, Madanlal B. Bhatt, Mitomycin and Fluorouracil in Combination with Concomitant Radiotherapy: A Potentially Curable Approach for Locally Advanced Head and Neck Squamous Cell Carcinoma, Japanese Journal of Clinical Oncology, Volume 35, Issue 10, October 2005, Pages 572–579, https://doi.org/10.1093/jjco/hyi155
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Abstract
Objective: The purpose of this study was to evaluate the efficacy of radiotherapy and concurrent mitomycin-C (MC) plus 5-fluorouracil (5FU) infusion in locally advanced squamous cell carcinoma of the head and neck (SCCHN).
Methods: Sixty-nine patients with SCCHN (6 Stage III and 63 Stage IV patients) were treated with external beam radiotherapy (70 Gy) and simultaneous intravenous chemotherapy with 5FU (600 mg/m2/day, Days 1–5) and MC (10 mg/m2, Days 5 and 36).
Results: After a mean follow-up of 28.5 months, 59.4% of patients were alive without disease. Complete response was seen in 76.8% of patients. The 3 years overall survival, locoregional relapse-free survival and disease-free survival was 62.3, 89.8 and 49.5%, respectively. Treatment was well tolerated (Grade III mucositis in 43.5% and Grade II leukopenia in 5.8%).
Conclusions: This concurrent chemoradiotherapy regimen offers a curative option for our patients where primary and nodal disease is fairly large resulting in hypoxic radioresistant tumors.
- radiation therapy
- fluorouracil
- hypoxia
- squamous cell carcinoma
- follow-up
- leukopenia
- mitomycin
- neoplasms
- head and neck squamous cell carcinoma
- radiochemotherapy
- teleradiotherapy procedure
- chemotherapy, intravenous
- head and neck
- mucositis
- external beam radiation therapy
- complete remission
- infusion procedures