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Volume 206, Issue 1_Supplement, May 2021
Immunology 2021™ Meeting Abstracts
Innovations in Therapy for Organ Specific Autoimmunity
Antigen-specific T cell tolerance in the prevention of post-infectious myocarditis induced with Coxsackievirus B3
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.01, https://doi.org/10.4049/jimmunol.206.Supp.18.01
Blocking IL1, IL33 and IL36 signaling by an anti-IL1RAP antibody is an efficient anti-inflammatory treatment that improves heart function in a model of autoimmune myocarditis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.02, https://doi.org/10.4049/jimmunol.206.Supp.18.02
Tissue-specific complement inhibition by antibody-Complement Regulatory Protein (CRP) fusions utilizing Therapeutic Autoimmune reguLatOry proteiN (TALON™) platform
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.04, https://doi.org/10.4049/jimmunol.206.Supp.18.04
Use of an Orally Delivered Oxysterol, a Lipid Membrane-Order (Lo) Disruptor, to Relieve IBD Symptoms in IL-10 Deficient Mouse Model
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.05, https://doi.org/10.4049/jimmunol.206.Supp.18.05
Induction with MHC variant peptide MOG 45D generates MOG-reactive T cells but no clinical disease
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.06, https://doi.org/10.4049/jimmunol.206.Supp.18.06
Deficiency in B Cell Maturation Antigen reveals sex differences in Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.07, https://doi.org/10.4049/jimmunol.206.Supp.18.07
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.08, https://doi.org/10.4049/jimmunol.206.Supp.18.08
CD40 on B cells and on dendritic cells mediates experimental autoimmune encephalomyelitis pathogenesis through distinct and complementary mechanisms
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.09, https://doi.org/10.4049/jimmunol.206.Supp.18.09
Evaluating the Effects of Intestinal Bacteria’s Production of GABA Neurotransmitter on an Animal Model of Multiple Sclerosis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.11, https://doi.org/10.4049/jimmunol.206.Supp.18.11
ST8Sia6 expression in beta cells mitigates onset of autoimmune diabetes in the murine NOD model
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.12, https://doi.org/10.4049/jimmunol.206.Supp.18.12
Generation of islet antigen-specific engineered Tregs for use in T1D therapy via homology-directed gene editing of conventional CD4+ T cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.13, https://doi.org/10.4049/jimmunol.206.Supp.18.13
BT-11 (omilancor), a first-in-class, topical therapeutic for psoriasis, ameliorates disease severity and inflammation through activation of LANCL2 pathway
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 18.14, https://doi.org/10.4049/jimmunol.206.Supp.18.14
Immunology of Infection 1
A role of B-cells and antibodies in generation of protective immune responses against a vaccinating antigen during non-albicans Candida mediated systemic candidiasis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.01, https://doi.org/10.4049/jimmunol.206.Supp.16.01
Metallothioneins reprograms T cell response towards pulmonary Histoplasma capsulatum through altering their metabolic profile
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.02, https://doi.org/10.4049/jimmunol.206.Supp.16.02
Distinct type I interferon (IFN) signaling is involved in damage and fungal clearance during Aspergillus pulmonary infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.03, https://doi.org/10.4049/jimmunol.206.Supp.16.03
Liver-localized CD8 T cells do not need Levy walks to be efficient killers
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.04, https://doi.org/10.4049/jimmunol.206.Supp.16.04
Candida albicans-induced EphA2 signaling promotes kidney injury and sepsis during invasive candidiasis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.05, https://doi.org/10.4049/jimmunol.206.Supp.16.05
Sialophorin is necessary for vaccine-induced CD8+ T cell responses and immunity against lethal fungal pneumonia in CD4+ T-cell deficient hosts
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.06, https://doi.org/10.4049/jimmunol.206.Supp.16.06
Immunopathology and Meningitis During Late-Onset Gut-Originating Neonatal Sepsis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.07, https://doi.org/10.4049/jimmunol.206.Supp.16.07
Pseudomonas aeruginosa Outer Membrane Vesicles (OMVs) Cause Inflammation and Cardiomyocyte Contractile Dysfunction
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.08, https://doi.org/10.4049/jimmunol.206.Supp.16.08
A dysbiotic gut microbiome suppresses antibody-mediated protection against Vibrio cholerae
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.09, https://doi.org/10.4049/jimmunol.206.Supp.16.09
Mycobacterium tuberculosis modulates DC-T cell cross-talk and Th17 polarization by dampening Notch signaling
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.10, https://doi.org/10.4049/jimmunol.206.Supp.16.10
Complement Receptor 3, but not Fcγ Receptor III, abolishes the intracellular survival advantage of virulent Rhodococcus equi in murine macrophages
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.11, https://doi.org/10.4049/jimmunol.206.Supp.16.11
Harnessing Regulatory T cells to Suppress Pathological Immune Response during Cryptococcus neoformans Meningoencephalitis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.12, https://doi.org/10.4049/jimmunol.206.Supp.16.12
The infection-chronic disease link: chronic kidney disease abate immunity in Porphyromonas gingivalis infection leading to pathogen overgrowth and kidney degeneration
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.13, https://doi.org/10.4049/jimmunol.206.Supp.16.13
B-Cell Responses in the Lung during Acute Pneumocystis Infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.14, https://doi.org/10.4049/jimmunol.206.Supp.16.14
IL-12p40 and Type 1 immunity are induced by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.15, https://doi.org/10.4049/jimmunol.206.Supp.16.15
Characterization of beta2-adrenergic receptor homozygous knockout stress mouse model during Chlamydia muridarum genital infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.16, https://doi.org/10.4049/jimmunol.206.Supp.16.16
The origin and fate of malaria-associated atypical memory B cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.17, https://doi.org/10.4049/jimmunol.206.Supp.16.17
Dysregulated neutrophils failed to control bacteria in an intradermal murine model of Orientia tsutsugamushi infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.18, https://doi.org/10.4049/jimmunol.206.Supp.16.18
MALNUTRITION IMPACTS PROTECTIVE IMMUNE RESPONSES AND MUCOSAL IMMUNITY DURING VISCERAL LEISHMANIASIS
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.19, https://doi.org/10.4049/jimmunol.206.Supp.16.19
Nod2-deficient CD4+ T cells protect against Candida albicans infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.20, https://doi.org/10.4049/jimmunol.206.Supp.16.20
The corruption of innate immunity by Streptococcus anginosus group
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.21, https://doi.org/10.4049/jimmunol.206.Supp.16.21
Plasmodium falciparum-specific B cell responses in malaria-susceptible children and malaria-immune adults
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.22, https://doi.org/10.4049/jimmunol.206.Supp.16.22
Ineffective CD4 T cell polarization reveals a novel immune evasion target of Borrelia burgdorferi
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.23, https://doi.org/10.4049/jimmunol.206.Supp.16.23
Airway bacteria prime innate immune protection against Streptococcus pneumoniae
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.24, https://doi.org/10.4049/jimmunol.206.Supp.16.24
Dual transcriptomics to decipher the interferon-gamma independent responses to intestinal Cryptosporidium parvum infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.25, https://doi.org/10.4049/jimmunol.206.Supp.16.25
The purinergic receptor P2RX7 promotes the accumulation of effector CD4+ T cells in the lung parenchyma during hypervirulent mycobacterial infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.26, https://doi.org/10.4049/jimmunol.206.Supp.16.26
Prime-Trap immunization with protective liver stage antigen, MIF-4G and Kb17 peptide, induces liver CD8 TRM cells and protection against Plasmodium berghei malaria
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.27, https://doi.org/10.4049/jimmunol.206.Supp.16.27
Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.28, https://doi.org/10.4049/jimmunol.206.Supp.16.28
Effector function prior to establishment of the phagosomal pathogen niche is required for protective CD4+ T cell-mediated immunity against Leishmania
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.29, https://doi.org/10.4049/jimmunol.206.Supp.16.29
Murine iNOS expression is essential for antifungal defenses in kidneys during disseminated cryptococcosis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.30, https://doi.org/10.4049/jimmunol.206.Supp.16.30
Microbiota regulate the induction and proliferation of revival intestinal stem cells through inflammatory cytokines
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 16.31, https://doi.org/10.4049/jimmunol.206.Supp.16.31
Autoimmunity and Primary Immune Deficiency
Dual IgA/IgG family plasmablast-derived mAbs from peripheral blood of individuals at risk for rheumatoid arthritis are polyreactive to autoantigens and intestinal bacteria
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.01, https://doi.org/10.4049/jimmunol.206.Supp.52.01
T cell dysfunction in Activated PI3K δ Syndrome explained by cell intrinsic and extrinsic components
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.02, https://doi.org/10.4049/jimmunol.206.Supp.52.02
Two lineages of memory B cell development regulated by type I interferon and IL-4R are perturbed in systemic lupus erythematosus
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.03, https://doi.org/10.4049/jimmunol.206.Supp.52.03
γHV68 infection exacerbates arthritis and requires age-associated B cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.04, https://doi.org/10.4049/jimmunol.206.Supp.52.04
Kidney macrophages in human lupus nephritis and mouse models express conserved inflammatory and remodeling gene programs and localize to the same anatomic sub-compartments
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.05, https://doi.org/10.4049/jimmunol.206.Supp.52.05
Human monoclonal autoantibodies in autoimmune basal ganglia encephalitis target dopamine receptors and act as drug agonists
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.06, https://doi.org/10.4049/jimmunol.206.Supp.52.06
Disease-associated dominant negative CARD11 mutations perturb the CARD11 Opening step during T cell receptor-induced activation of NF-κB and JNK2
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.07, https://doi.org/10.4049/jimmunol.206.Supp.52.07
The deficiency of Cbl family in human elicits heightened T-dependent immune activation with augmentation of TFH responses
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.08, https://doi.org/10.4049/jimmunol.206.Supp.52.08
Inherited human PD-1 deficiency underlies tuberculosis and autoimmunity
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.10, https://doi.org/10.4049/jimmunol.206.Supp.52.10
Lymphocyte phenotype in a mouse model of 22q11.2 deletion syndrome
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.11, https://doi.org/10.4049/jimmunol.206.Supp.52.11
Anti-TRIM21 antibody seropositivity is related to B-cell abnormalities in systemic lupus erythematosus
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.12, https://doi.org/10.4049/jimmunol.206.Supp.52.12
Role of B-cell endogenous interferon beta in lupus nephritis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.13, https://doi.org/10.4049/jimmunol.206.Supp.52.13
Genetic studies play an important role in the correct diagnosis of congenital immunodeficiency conditions
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.14, https://doi.org/10.4049/jimmunol.206.Supp.52.14
RGC-32 Facilitates Reactive Astrocytosis in Experimental Autoimmune Encephalomyelitis (EAE) by Maintaining a Mature Phenotype
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.15, https://doi.org/10.4049/jimmunol.206.Supp.52.15
Pertussis toxin inhibits encephalitogenic T cell infiltration and promotes a B cell driven disease during TH17-EAE
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.16, https://doi.org/10.4049/jimmunol.206.Supp.52.16
Borrelia burgdorferi peptidoglycan triggers inflammatory responses in Lyme arthritis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.17, https://doi.org/10.4049/jimmunol.206.Supp.52.17
PI3Kd coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells at the expense of memory
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.18, https://doi.org/10.4049/jimmunol.206.Supp.52.18
A survey of current research trends and potential future directions in reproductive immunology clinical trials
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.19, https://doi.org/10.4049/jimmunol.206.Supp.52.19
A novel variant in CoQ biosynthesis highly prevalent in Papua New Guinea children increases mortality following bacterial pneumonia
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.20, https://doi.org/10.4049/jimmunol.206.Supp.52.20
DOCK8-expressing Tfh cells cause SLE: autoimmunity via repeated TCR stimulation by antigen to levels that surpass system’s self-organized criticality
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.21, https://doi.org/10.4049/jimmunol.206.Supp.52.21
Crosstalk of TDP-43 and Optineurin in in vitro and ex vivo Models of Amyotrophic Lateral Sclerosis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.22, https://doi.org/10.4049/jimmunol.206.Supp.52.22
Single cell profiling identifies IgMMDA-LDL-producing human B cells and a novel role for CD24
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 52.23, https://doi.org/10.4049/jimmunol.206.Supp.52.23
Innate Immune Sensing and Signaling
Mitochondrial calcium uniporter positively regulates phagocytosis-dependent activation of NLRP3 inflammasome
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.01, https://doi.org/10.4049/jimmunol.206.Supp.15.01
Tlr3 interacts with ESCRT-I components Tsg101 and Hcrp1 in mouse astrocyte cell line
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.02, https://doi.org/10.4049/jimmunol.206.Supp.15.02
Recognition of gasdermins by proteases
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.03, https://doi.org/10.4049/jimmunol.206.Supp.15.03
Defining intracellular signaling pathways that dictate a universal antiviral response to conserved viral architectures in TLR2/6-dependent manner
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.04, https://doi.org/10.4049/jimmunol.206.Supp.15.04
Regulation of TLR9 signaling by N-glycosylation of UNC93B1
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.05, https://doi.org/10.4049/jimmunol.206.Supp.15.05
TurboID biotin-tagging mass spectrometry identifies specific caspase-11-associated proteins regulating non-canonical inflammasome activation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.06, https://doi.org/10.4049/jimmunol.206.Supp.15.06
An AGS associated mutation causes cellular RNA editing deficiency in mouse brain which lead to IFN pathway activation, mimicking the interferonopathy of patient brains
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.07, https://doi.org/10.4049/jimmunol.206.Supp.15.07
In silico mapping of 14-3-3ζ and Human TRAF interaction
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.09, https://doi.org/10.4049/jimmunol.206.Supp.15.09
-Itaconate confers tolerance to late NLRP3 inflammasome activation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.11, https://doi.org/10.4049/jimmunol.206.Supp.15.11
The leaked mitochondrial C1QBP inhibits activation of the DNA sensor cGAS
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.12, https://doi.org/10.4049/jimmunol.206.Supp.15.12
DNA-PK senses DNA virus infection in human cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.13, https://doi.org/10.4049/jimmunol.206.Supp.15.13
Contribution of the NADase function of bacterial TIR domain proteins to the inhibition of innate immune responses
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.14, https://doi.org/10.4049/jimmunol.206.Supp.15.14
USP13 enhances the function of p62/SQSTM1 by increasing its stability and aggregate formation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.15, https://doi.org/10.4049/jimmunol.206.Supp.15.15
Citrin, a mitochondrial transporter, interacts with NLRP3 and regulates inflammasome activity
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.16, https://doi.org/10.4049/jimmunol.206.Supp.15.16
Phosphorylation and Chromatin Tethering Prevent cGAS activation During Mitosis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 15.17, https://doi.org/10.4049/jimmunol.206.Supp.15.17
Molecular and Metabolic Control of Innate Immunity
The link between Complement System and Anemia in Gaucher disease
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.01, https://doi.org/10.4049/jimmunol.206.Supp.64.01
Deubiquitination of NLRP6 by Cyld critically regulates colonic inflammation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.02, https://doi.org/10.4049/jimmunol.206.Supp.64.02
MAPK regulates the immune responses in liver cirrhosis and hepatocellular carcinoma
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.03, https://doi.org/10.4049/jimmunol.206.Supp.64.03
Downregulation of AW112010 upon treatment with 6-formylindolo[3,2-b] carbazole protects mice from fulminant Concanavalin-induced T cell-mediated liver injury
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.06, https://doi.org/10.4049/jimmunol.206.Supp.64.06
Dysregulation of microRNA expression in chronic periodontitis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.07, https://doi.org/10.4049/jimmunol.206.Supp.64.07
The type 1 diabetes-associated A946T single nucleotide polymorphism in IFIH1 results in increased type I interferon signaling
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.08, https://doi.org/10.4049/jimmunol.206.Supp.64.08
Genetic regulation of nitric oxide-mediated metabolic reprogramming in dendritic cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.09, https://doi.org/10.4049/jimmunol.206.Supp.64.09
Long noncoding RNAs RN7SK and GAS5 Regulate Macrophage Innate Immune Function and Polarization
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.10, https://doi.org/10.4049/jimmunol.206.Supp.64.10
Tolerance Induction by Exopolysaccharide from the Probiotic Bacillus subtilis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.11, https://doi.org/10.4049/jimmunol.206.Supp.64.11
Investigating the impact of TLR ligand induced Id2 expression in dendritic cell development and function
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.12, https://doi.org/10.4049/jimmunol.206.Supp.64.12
Glycolysis Inhibition Modulates Unique Metabolic and Immune Pathways Across Multiple Tissue Compartments
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.13, https://doi.org/10.4049/jimmunol.206.Supp.64.13
Hyper MAPK/ERK signaling in DCs causes increased LPS-induced TNFa at the post-transcriptional level
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.14, https://doi.org/10.4049/jimmunol.206.Supp.64.14
Distinct chromatin modifications at the Il33 locus in mast cells contribute to sex dimorphic susceptibility to EAE, an autoimmune CNS demyelinating disease
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.15, https://doi.org/10.4049/jimmunol.206.Supp.64.15
P2X3 is a Female-Dominant Activator of Mast Cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.16, https://doi.org/10.4049/jimmunol.206.Supp.64.16
Itaconate deficiency results in prolonged bacterial burdens and enhanced T cell responses during Francisella tularensis infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.17, https://doi.org/10.4049/jimmunol.206.Supp.64.17
Chromatin accessibility differences of human monocyte identify age associated inflammatory heterogeneity
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.18, https://doi.org/10.4049/jimmunol.206.Supp.64.18
The role of the transcriptional repressor YY1 in immunoregulatory gp96-mediated immune responses
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.19, https://doi.org/10.4049/jimmunol.206.Supp.64.19
Non-Thermal Histotripsy Ablation of Osteosarcoma Causes a Local Acute Immune Response
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.20, https://doi.org/10.4049/jimmunol.206.Supp.64.20
A role of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.21, https://doi.org/10.4049/jimmunol.206.Supp.64.21
Mixed Lineage Kinase 3 Promotes Dexamethasone-Induced Thymocyte Apoptosis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 64.23, https://doi.org/10.4049/jimmunol.206.Supp.64.23
Novel Strategies for the Vaccination and Immunotherapy Against Infectious Diseases
Nasal immunization with mast cell activating small molecules protects mice against West Nile Virus infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.01, https://doi.org/10.4049/jimmunol.206.Supp.59.01
Lipid A mimetics BECC438 and BECC470 potentiate durable and balanced immune responses using an ovalbumin murine vaccine model
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.02, https://doi.org/10.4049/jimmunol.206.Supp.59.02
Adjuvanted bacteriophage vaccine targeting Pseudomonas aeruginosa
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.03, https://doi.org/10.4049/jimmunol.206.Supp.59.03
Prefusion F-based polyanhydride nanovaccine induces robust humoral and cell-mediated immunity resulting in long-lasting protection against respiratory syncytial virus
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.04, https://doi.org/10.4049/jimmunol.206.Supp.59.04
Mucosal delivery of a polyanhydride nanovaccine incorporating CpG and the post-fusion F/ G proteins induces protective immunity against BRSV infection in neonatal calves
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.05, https://doi.org/10.4049/jimmunol.206.Supp.59.05
Presence of maternal antibody at initial respiratory syncytial virus (RSV) infection shapes innate and adaptive responses following repeat RSV exposure
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.06, https://doi.org/10.4049/jimmunol.206.Supp.59.06
A Protein Subunit Filovirus Vaccine Facilitates Maternal Immunization in Mice
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.07, https://doi.org/10.4049/jimmunol.206.Supp.59.07
Comparison of young-versus-old cytokine expression profiles in response to TLR agonists in murine and human whole blood
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.08, https://doi.org/10.4049/jimmunol.206.Supp.59.08
The Impact of Advanced Age on Vaccine-Induced Tissue Immune Recall Responses
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.10, https://doi.org/10.4049/jimmunol.206.Supp.59.10
Intravenous BCG protects SIV+ macaques from tuberculosis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.11, https://doi.org/10.4049/jimmunol.206.Supp.59.11
Genetically engineered CD4 T cells as a novel immunotherapy against drug resistant Klebsiella pneumoniae infections
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.12, https://doi.org/10.4049/jimmunol.206.Supp.59.12
Probing the naturally acquired immune response to malaria for broadly reactive antibodies targeting P. falciparum antigens linked with severe disease
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.13, https://doi.org/10.4049/jimmunol.206.Supp.59.13
In-vivo engineering of B cells elicits memory retention and allows for secretion of broadly neutralizing antibodies in mice
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.14, https://doi.org/10.4049/jimmunol.206.Supp.59.14
Allelic polymorphism gates vaccine amplification of a human broadly neutralizing response against influenza virus
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.15, https://doi.org/10.4049/jimmunol.206.Supp.59.15
Broadly reactive human antibodies prevent and treat pneumococcal infection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.16, https://doi.org/10.4049/jimmunol.206.Supp.59.16
Sensing of antigen affinity and kinetic rates by B cells expressing receptors of HIV-1 broadly neutralizing antibodies
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.17, https://doi.org/10.4049/jimmunol.206.Supp.59.17
Increased disease severity of Ebola virus infection with blockade of CD47
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.18, https://doi.org/10.4049/jimmunol.206.Supp.59.18
A Factor H-Fc fusion protein competes with serum FH for binding to Staphylococcus aureus and boosts complement-mediated opsonization
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.20, https://doi.org/10.4049/jimmunol.206.Supp.59.20
Reading the writing of immunizations in mice – the quantitative assessment of secreted antibodies to evaluate the quality of immunizations
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.21, https://doi.org/10.4049/jimmunol.206.Supp.59.21
Computational models of Immunity – Pertussis Boost (CMI-PB): Engaging the broader scientific community to develop predictive models of Tdap booster vaccination.
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.22, https://doi.org/10.4049/jimmunol.206.Supp.59.22
The Nanobody JK36 circumvents the epitope overlapping commonly observed between therapeutic anti-CD38 antibodies and commercially available analytical mouse antibodies
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 59.24, https://doi.org/10.4049/jimmunol.206.Supp.59.24
It’s All in the Cells: T Cells, Mast Cells, Basophils, and ILC’s
L-type amino acid transporter 1 is essential for Th2 cell-mediated allergic inflammation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.01, https://doi.org/10.4049/jimmunol.206.Supp.23.01
Functional characterization of gamma-delta (γδ) T cells in allergy
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.02, https://doi.org/10.4049/jimmunol.206.Supp.23.02
Murine Th9 cell-mediated allergic inflammation shows different steroid responsiveness depending on target organs
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.03, https://doi.org/10.4049/jimmunol.206.Supp.23.03
Loss of isoprenylation significantly reduces IgE mediated mast cell activation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.04, https://doi.org/10.4049/jimmunol.206.Supp.23.04
Neurokinin A blocks the ABCA1 channel to promote IL-10-dependent mast cell regulation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.05, https://doi.org/10.4049/jimmunol.206.Supp.23.05
Na+/H+ exchanger regulatory factor 1 (NHERF1) enhances MRGPRX2-mediated mast cell anaphylaxis
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.06, https://doi.org/10.4049/jimmunol.206.Supp.23.06
Phytochemical Effects on FcepsilonRI and MrgprX2-mediated Activation of Human Mast Cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.07, https://doi.org/10.4049/jimmunol.206.Supp.23.07
Characterization of the mast cell surface proteome leads to the identification of CD98hc as a critical surface molecule for optimal mast cell function
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.08, https://doi.org/10.4049/jimmunol.206.Supp.23.08
Glycogen synthase kinase 3 (GSK3) is a critical regulator of allergen-mediated mast cell activation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.09, https://doi.org/10.4049/jimmunol.206.Supp.23.09
Activation of human skin mast cells by vancomycin via MrgX2: Comparison to the effects of brimonidine
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.10, https://doi.org/10.4049/jimmunol.206.Supp.23.10
IL-33 sensitizes mast cells to ATP-induced cytokine secretion
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.11, https://doi.org/10.4049/jimmunol.206.Supp.23.11
A Basophil-Neuronal Axis Promotes Itch Flares
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.12, https://doi.org/10.4049/jimmunol.206.Supp.23.12
A history of microbial exposures has a temporally limited inhibitory effect on mouse lung ILC2 responses to a fungal allergen
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.13, https://doi.org/10.4049/jimmunol.206.Supp.23.13
Internalization of benzylisoquinoline alkaloids by resting and activated bone marrow-derived mast cells utilizes energy-dependent mechanisms
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.14, https://doi.org/10.4049/jimmunol.206.Supp.23.14
Human and mouse mast cells express surface PrP that is shed upon activation and affects degranulation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 23.15, https://doi.org/10.4049/jimmunol.206.Supp.23.15
Transplantation Immunology
Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.01, https://doi.org/10.4049/jimmunol.206.Supp.28.01
TCF-1 acts as a positive regulator in alloactivated T cells, and TCF-1 deficiency reduces GVHD yet maintains GVT responses
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.02, https://doi.org/10.4049/jimmunol.206.Supp.28.02
Identification and function of a CD4+/CD8αβ+ T cell population that is predictive of GVHD development in a xenogeneic transplant model
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.03, https://doi.org/10.4049/jimmunol.206.Supp.28.03
Interleukin-2-Inducible T-cell Kinase (ITK) signaling regulates non-canonical regulatory T cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.04, https://doi.org/10.4049/jimmunol.206.Supp.28.04
Flt3 ligand expressed on the surface of T-cells contributes to effector function
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.05, https://doi.org/10.4049/jimmunol.206.Supp.28.05
IL-33 is a critical early activation and differentiation signal for alloreactive CD4+ T cells that enables their infiltration into GVHD target tissues
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.06, https://doi.org/10.4049/jimmunol.206.Supp.28.06
Vγ2+ gamma-delta (γδ) T cells promotes the survival of skin allografts in the presence of anti-CD40L induced transplantation tolerance
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.07, https://doi.org/10.4049/jimmunol.206.Supp.28.07
The effects of UW Solutions in preventing ischemia induced apoptosis of retinal ganglion cells after whole eye transplantation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.08, https://doi.org/10.4049/jimmunol.206.Supp.28.08
Durvalumab and Lenvatinib in Participants With Locally Advanced and Metastatic Hepatocellular Carcinoma (Dulect2020-1)
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.09, https://doi.org/10.4049/jimmunol.206.Supp.28.09
Invariant NKT cells promote expansion of novel CXCR3+CCR4+CD8+ T cells in the liver following allogeneic hepatocyte transplant
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.11, https://doi.org/10.4049/jimmunol.206.Supp.28.11
Transplantation and CMV promote premature aging of CD8 T cells
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.12, https://doi.org/10.4049/jimmunol.206.Supp.28.12
Impact of neutrophil extracellular traps (NETs) in primary graft dysfunction following human lung transplantation
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.13, https://doi.org/10.4049/jimmunol.206.Supp.28.13
Xenogeneic Sertoli cells express complement inhibitory proteins necessary for their survival of hyperacute rejection
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.14, https://doi.org/10.4049/jimmunol.206.Supp.28.14
DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival
The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 28.15, https://doi.org/10.4049/jimmunol.206.Supp.28.15
