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Azizath Moussiliou, Maroufou J. Alao, Lise Denoeud-Ndam, Rachida Tahar, Sem Ezimegnon, Gratien Sagbo, Annick Amoussou, Adrian J.F. Luty, Philippe Deloron, Nicaise Tuikue Ndam, High Plasma Levels of Soluble Endothelial Protein C Receptor Are Associated With Increased Mortality Among Children With Cerebral Malaria in Benin, The Journal of Infectious Diseases, Volume 211, Issue 9, 1 May 2015, Pages 1484–1488, https://doi.org/10.1093/infdis/jiu661
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Abstract
Loss of endothelial protein C receptor (EPCR) occurs at the sites of Plasmodium falciparum–infected erythrocyte sequestration in patients with or who died from cerebral malaria. In children presenting with different clinical syndromes of malaria, we assessed the relationships between endogenous plasma soluble EPCR (sEPCR) levels and clinical presentation or mortality. After adjustment for age, for treatment before admission, and for a known genetic factor, sEPCR level at admission was positively associated with cerebral malaria (P = .011) and with malaria-related mortality (P = .0003). Measuring sEPCR levels at admission could provide an early biological marker of the outcome of cerebral malaria.