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Rajapandian Sivaganesa Karthikeyan, Chairut Vareechon, Namperumalsamy Venkatesh Prajna, Kuppamuthu Dharmalingam, Eric Pearlman, Prajna Lalitha, Interleukin 17 Expression in Peripheral Blood Neutrophils From Fungal Keratitis Patients and Healthy Cohorts in Southern India, The Journal of Infectious Diseases, Volume 211, Issue 1, 1 January 2015, Pages 130–134, https://doi.org/10.1093/infdis/jiu381
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Abstract
Interleukin 17A (IL-17) production by peripheral blood neutrophils was examined in patients with fungal keratitis and in uninfected individuals in southern India, which has high levels of airborne Aspergillus and Fusarium conidia. Il17a gene expression and intracellular IL-17 were detected in all groups, although levels were significantly elevated in neutrophils from patients with keratitis. There were no significant differences in plasma IL-17 and IL-23 between patients with keratitis and uninfected individuals; however, combined data from all groups showed a correlation between the percentage IL-17 producing neutrophils and plasma IL-23, and between plasma IL-17 and IL-6 and IL-23.